CRCGN015_MCF10A.TP53.M_24H:M23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-nitropyrene 33.98 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

220 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:M23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.41545
TCEA2 transcription elongation factor A (SII), 2 5.1652
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 4.84869
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.5896
ADAM10 ADAM metallopeptidase domain 10 4.55868
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 4.32212
PPARG peroxisome proliferator-activated receptor gamma 3.9752
LGMN legumain 3.94475
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 3.86278
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.85635
TICAM1 toll-like receptor adaptor molecule 1 3.83575
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 3.7752
RGS2 regulator of G-protein signaling 2 3.4459
KEAP1 kelch-like ECH-associated protein 1 3.3469
CYB5B cytochrome b5 type B (outer mitochondrial membrane) 3.22355
GATA2 GATA binding protein 2 3.1044
HBA1 hemoglobin, alpha 1 3.02357
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 3.01393
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.98275
PYCR1 pyrroline-5-carboxylate reductase 1 2.97925
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.95685
PICK1 protein interacting with PRKCA 1 2.89655
CLBA1 clathrin binding box of aftiphilin containing 1 2.85875
GET1 guided entry of tail-anchored proteins factor 1 2.83365
SESN1 sestrin 1 2.78655
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 2.7825
INPP1 inositol polyphosphate-1-phosphatase 2.73435
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 2.728
MRPL34 mitochondrial ribosomal protein L34 2.71485
SETD1A SET domain containing 1A 2.6977
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 2.6693
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.6628
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.65695
PARP2 poly (ADP-ribose) polymerase 2 2.62947
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 2.58765
ST20-MTHFS ST20-MTHFS readthrough 2.58185
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 2.5578
CNRIP1 cannabinoid receptor interacting protein 1 2.55735
TMEM186 transmembrane protein 186 2.4953
EGLN1 egl-9 family hypoxia-inducible factor 1 2.4918
ZNF574 zinc finger protein 574 2.48185
ORC6 origin recognition complex, subunit 6 2.45825
UBE2W ubiquitin-conjugating enzyme E2W (putative) 2.4501
DENND4B DENN/MADD domain containing 4B 2.4241
ZNF14 zinc finger protein 14 2.4207
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 2.40765
ZNF646 zinc finger protein 646 2.38635
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.3841
UBL5 ubiquitin-like 5 2.3568
FN3KRP fructosamine 3 kinase related protein 2.3557
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia) 2.3477
HDAC7 histone deacetylase 7 2.3409
BCAS1 breast carcinoma amplified sequence 1 2.33825
NAP1L3 nucleosome assembly protein 1-like 3 2.3242
TSPAN6 tetraspanin 6 2.31945
TPM1 tropomyosin 1 (alpha) 2.29474
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2.27565
CLDN6 claudin 6 2.27255
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2.26815
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3 2.25715
INTS3 integrator complex subunit 3 2.25075
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 2.249
TP53 tumor protein p53 2.24787
ARL4D ADP-ribosylation factor-like 4D 2.24335
OCEL1 occludin/ELL domain containing 1 2.2407
DEXI Dexi homolog (mouse) 2.22455
TOE1 target of EGR1, member 1 (nuclear) 2.22365
WHRN whirlin 2.2187
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1 2.2171
PRSS53 protease, serine, 53 2.2055
NCBP3 nuclear cap binding subunit 3 2.2036
ASF1B anti-silencing function 1B histone chaperone 2.198
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 2.18065
ABI3BP ABI family, member 3 (NESH) binding protein 2.1714
MBIP MAP3K12 binding inhibitory protein 1 2.1501
BOLA2B bolA family member 2B 2.1439
WDR83OS WD repeat domain 83 opposite strand 2.1351
LIN7B lin-7 homolog B (C. elegans) 2.13
ELAVL3 ELAV like neuron-specific RNA binding protein 3 2.1299
THUMPD1 THUMP domain containing 1 2.12902
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 2.11975
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.11875
FABP4 fatty acid binding protein 4, adipocyte 2.10735
SRSF7 serine/arginine-rich splicing factor 7 2.10207
TCF15 transcription factor 15 (basic helix-loop-helix) 2.10085
PFDN2 prefoldin subunit 2 2.09935
MRPS16 mitochondrial ribosomal protein S16 2.0977
NDN necdin, melanoma antigen (MAGE) family member 2.09385
WIF1 WNT inhibitory factor 1 2.0902
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase 2.0767
TMEM255A transmembrane protein 255A 2.0736
ZFYVE21 zinc finger, FYVE domain containing 21 2.0695
ATF7IP2 activating transcription factor 7 interacting protein 2 2.06455
CTF1 cardiotrophin 1 2.06185
CFAP298 cilia and flagella associated protein 298 2.05595
BTG2 BTG family, member 2 2.0522
USP1 ubiquitin specific peptidase 1 2.0504
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.0476
ADRB2 adrenoceptor beta 2, surface 2.04115
ATF5 activating transcription factor 5 2.03935
RUFY1 RUN and FYVE domain containing 1 2.03915
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) 2.0354
CDK2 cyclin-dependent kinase 2 2.03478
SIAH2 siah E3 ubiquitin protein ligase 2 2.0329
ELP5 elongator acetyltransferase complex subunit 5 2.0297
DUX4 double homeobox 4 2.02835
CPEB1 cytoplasmic polyadenylation element binding protein 1 2.0277
UPK1B uroplakin 1B 2.02308
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) 2.01985
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 2.01665
ARMCX6 armadillo repeat containing, X-linked 6 2.0142
CMC2 C-x(9)-C motif containing 2 2.0092
TOB1 transducer of ERBB2, 1 2.0066
GJC2 gap junction protein, gamma 2, 47kDa 2.00335
RPP25 ribonuclease P/MRP 25kDa subunit 2.0023

decreased expression

Symbol Name Standardized Value
MSRA methionine sulfoxide reductase A -6.77755
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -6.05135
UBE3C ubiquitin protein ligase E3C -5.57365
DDIT4 DNA-damage-inducible transcript 4 -5.39555
TCTA T-cell leukemia translocation altered -5.28755
LAP3 leucine aminopeptidase 3 -5.1193
HAT1 histone acetyltransferase 1 -5.04865
KRT14 keratin 14, type I -5.0
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -4.56385
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -4.22262
ASCC3 activating signal cointegrator 1 complex subunit 3 -4.11235
ATP11B ATPase, class VI, type 11B -3.80695
MNAT1 MNAT CDK-activating kinase assembly factor 1 -3.74545
DDB2 damage-specific DNA binding protein 2, 48kDa -3.689
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -3.6416
HSPA1A heat shock 70kDa protein 1A -3.604
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 -3.54605
BID BH3 interacting domain death agonist -3.35308
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -3.3462
ANO10 anoctamin 10 -3.33875
TRIB3 tribbles pseudokinase 3 -3.3209
TKT transketolase -3.30603
PPA1 pyrophosphatase (inorganic) 1 -3.2149
SSBP2 single-stranded DNA binding protein 2 -3.14342
STXBP2 syntaxin binding protein 2 -2.96235
SOX9 SRY (sex determining region Y)-box 9 -2.84368
PTK2 protein tyrosine kinase 2 -2.82022
HSPA8 heat shock 70kDa protein 8 -2.80245
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.7801
ELOVL6 ELOVL fatty acid elongase 6 -2.72327
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -2.7026
FOXF2 forkhead box F2 -2.64385
NKX3-2 NK3 homeobox 2 -2.6071
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.60635
REXO2 RNA exonuclease 2 -2.59109
CUBN cubilin (intrinsic factor-cobalamin receptor) -2.5706
SFT2D2 SFT2 domain containing 2 -2.5566
GRB10 growth factor receptor-bound protein 10 -2.55515
ZSCAN5A zinc finger and SCAN domain containing 5A -2.52895
NLGN4Y neuroligin 4, Y-linked -2.5282
SRPK1 SRSF protein kinase 1 -2.50645
MSMO1 methylsterol monooxygenase 1 -2.4828
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -2.44685
IL15RA interleukin 15 receptor, alpha -2.44535
CDCP1 CUB domain containing protein 1 -2.4383
EPHB2 EPH receptor B2 -2.42485
GPR87 G protein-coupled receptor 87 -2.42085
VAMP8 vesicle-associated membrane protein 8 -2.41475
REEP5 receptor accessory protein 5 -2.38873
SIX2 SIX homeobox 2 -2.38462
ADGRA2 adhesion G protein-coupled receptor A2 -2.3701
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -2.3647
PRSS2 protease, serine, 2 (trypsin 2) -2.36185
ZNF385D zinc finger protein 385D -2.3398
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.3351
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) -2.32915
COL2A1 collagen, type II, alpha 1 -2.32105
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 -2.3154
NTF3 neurotrophin 3 -2.30975
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.3002
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -2.29283
GBP1 guanylate binding protein 1, interferon-inducible -2.28525
LAMB3 laminin, beta 3 -2.269
EXOC2 exocyst complex component 2 -2.2545
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) -2.25385
DCAF6 DDB1 and CUL4 associated factor 6 -2.2388
RBM6 RNA binding motif protein 6 -2.23
FAT4 FAT atypical cadherin 4 -2.2265
PTPRK protein tyrosine phosphatase, receptor type, K -2.22605
NCAPD2 non-SMC condensin I complex, subunit D2 -2.2253
COL4A1 collagen, type IV, alpha 1 -2.22233
GPHN gephyrin -2.21305
CX3CL1 chemokine (C-X3-C motif) ligand 1 -2.18792
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 -2.16505
TTC28 tetratricopeptide repeat domain 28 -2.15585
PSRC1 proline/serine-rich coiled-coil 1 -2.15585
FJX1 four jointed box 1 (Drosophila) -2.15355
APOM apolipoprotein M -2.14398
SOX11 SRY (sex determining region Y)-box 11 -2.14128
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -2.13565
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -2.12348
PRSS58 protease, serine, 58 -2.09155
WRN Werner syndrome, RecQ helicase-like -2.0889
EPHB3 EPH receptor B3 -2.0869
MED28 mediator complex subunit 28 -2.08565
MAST4 microtubule associated serine/threonine kinase family member 4 -2.08302
DPEP1 dipeptidase 1 (renal) -2.07805
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13 -2.0659
RAB11FIP3 RAB11 family interacting protein 3 (class II) -2.0655
MAP2K5 mitogen-activated protein kinase kinase 5 -2.05175
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 -2.0512
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -2.04345
G6PC1 glucose-6-phosphatase catalytic subunit 1 -2.0426
VMP1 vacuole membrane protein 1 -2.0391
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5 -2.03095
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 -2.02655
CDCA3 cell division cycle associated 3 -2.02215
CTRB1 chymotrypsinogen B1 -2.02185
SORBS3 sorbin and SH3 domain containing 3 -2.02005
ATF6 activating transcription factor 6 -2.0152
LHFPL6 LHFPL tetraspan subfamily member 6 -2.01305
COL4A2 collagen, type IV, alpha 2 -2.0109
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.00805
TGM4 transglutaminase 4 -2.00785
UPB1 ureidopropionase, beta -2.00205