CRCGN015_MCF10A.TP53.M_24H:M24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-nitropyrene 11.33 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

182 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:M24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SSBP2 single-stranded DNA binding protein 2 9.39248
CNRIP1 cannabinoid receptor interacting protein 1 5.0
SNAP25 synaptosomal-associated protein, 25kDa 4.86945
GET1 guided entry of tail-anchored proteins factor 1 4.24225
CASP7 caspase 7, apoptosis-related cysteine peptidase 3.49115
TCEA2 transcription elongation factor A (SII), 2 3.25055
BMS1 BMS1 ribosome biogenesis factor 3.2177
RINT1 RAD50 interactor 1 2.9629
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.8766
FAM32A family with sequence similarity 32, member A 2.74515
SESN1 sestrin 1 2.7335
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.70935
NSG2 neuronal vesicle trafficking associated 2 2.67895
ERCC3 excision repair cross-complementation group 3 2.65595
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2.6167
STAP2 signal transducing adaptor family member 2 2.53995
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa 2.5273
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha 2.51412
RGS2 regulator of G-protein signaling 2 2.5072
DIABLO diablo, IAP-binding mitochondrial protein 2.4984
STMN2 stathmin 2 2.4937
WIF1 WNT inhibitory factor 1 2.4637
DCK deoxycytidine kinase 2.4595
CNPY3 canopy FGF signaling regulator 3 2.4376
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.41975
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 2.4173
TICAM1 toll-like receptor adaptor molecule 1 2.3942
METTL17 methyltransferase like 17 2.36695
ATP5ME ATP synthase membrane subunit e 2.36308
INPP1 inositol polyphosphate-1-phosphatase 2.36305
CPAP centrosome assembly and centriole elongation protein 2.32
ATMIN ATM interactor 2.3108
OXSR1 oxidative stress responsive 1 2.2832
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) 2.27785
PARP2 poly (ADP-ribose) polymerase 2 2.25592
PDLIM2 PDZ and LIM domain 2 (mystique) 2.25345
CCNE2 cyclin E2 2.24997
MAGEA2B melanoma antigen family A2B 2.24855
MCUR1 mitochondrial calcium uniporter regulator 1 2.2365
PROM1 prominin 1 2.2311
AGR2 anterior gradient 2 2.22755
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa 2.2038
SYT1 synaptotagmin I 2.18923
CDK20 cyclin-dependent kinase 20 2.17695
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.1736
NLRP2B NLR family pyrin domain containing 2B 2.1592
ZMIZ1 zinc finger, MIZ-type containing 1 2.1502
HNRNPF heterogeneous nuclear ribonucleoprotein F 2.14995
CLDN4 claudin 4 2.1467
SMN2 survival of motor neuron 2, centromeric 2.1441
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase 2.132
BLM Bloom syndrome, RecQ helicase-like 2.12665
CPEB1 cytoplasmic polyadenylation element binding protein 1 2.12595
CRY1 cryptochrome circadian clock 1 2.1177
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.10795
SP3 Sp3 transcription factor 2.0986
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.09315
FRG1 FSHD region gene 1 2.0931
MAN2A2 mannosidase, alpha, class 2A, member 2 2.09232
POLR2F polymerase (RNA) II (DNA directed) polypeptide F 2.0832
RUNDC3A RUN domain containing 3A 2.0767
RPH3A rabphilin 3A 2.06925
RPS15 ribosomal protein S15 2.06645
RAB11A RAB11A, member RAS oncogene family 2.06465
CCP110 centriolar coiled coil protein 110kDa 2.05605
ELP5 elongator acetyltransferase complex subunit 5 2.049
CHEK1 checkpoint kinase 1 2.04638
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.0439
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 2.0349
MED4 mediator complex subunit 4 2.0319
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 2.02635
NRN1 neuritin 1 2.02495
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa 2.0197
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 2.01845
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 2.01555
TBP TATA box binding protein 2.0094
XPC xeroderma pigmentosum, complementation group C 2.00605
DCP2 decapping mRNA 2 2.00385
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 2.0038
TIPIN TIMELESS interacting protein 2.00015

decreased expression

Symbol Name Standardized Value
ITFG1 integrin alpha FG-GAP repeat containing 1 -6.61195
SGK1 serum/glucocorticoid regulated kinase 1 -5.1397
MSMO1 methylsterol monooxygenase 1 -5.0
TCTA T-cell leukemia translocation altered -4.9628
MSRA methionine sulfoxide reductase A -4.80715
DDIT4 DNA-damage-inducible transcript 4 -3.70595
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -3.69615
IFRD2 interferon-related developmental regulator 2 -3.6016
DOCK4 dedicator of cytokinesis 4 -3.14915
PNPLA3 patatin-like phospholipase domain containing 3 -3.1357
JMJD4 jumonji domain containing 4 -3.12935
ATF5 activating transcription factor 5 -3.09965
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 -2.97615
STXBP2 syntaxin binding protein 2 -2.91565
SOAT2 sterol O-acyltransferase 2 -2.90275
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) -2.7284
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) -2.706
TMEM115 transmembrane protein 115 -2.6668
FKBP8 FK506 binding protein 8, 38kDa -2.64915
FNBP1L formin binding protein 1-like -2.64495
CAPN15 calpain 15 -2.5827
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 -2.56625
CCRL2 chemokine (C-C motif) receptor-like 2 -2.55035
TKT transketolase -2.54278
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) -2.52015
APEH acylaminoacyl-peptide hydrolase -2.47985
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) -2.4642
TMEM223 transmembrane protein 223 -2.46225
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 -2.4595
GPD1L glycerol-3-phosphate dehydrogenase 1-like -2.45915
SLC17A2 solute carrier family 17, member 2 -2.45005
PSKH1 protein serine kinase H1 -2.43385
ZHX2 zinc fingers and homeoboxes 2 -2.43075
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 -2.36995
FZD10 frizzled class receptor 10 -2.3252
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 -2.31415
TGM4 transglutaminase 4 -2.2847
COL17A1 collagen, type XVII, alpha 1 -2.266
ALPL alkaline phosphatase, liver/bone/kidney -2.25785
TRIM66 tripartite motif containing 66 -2.24335
ANKH ANKH inorganic pyrophosphate transport regulator -2.23385
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 -2.22805
HSF1 heat shock transcription factor 1 -2.22725
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha -2.21305
ACSM2A acyl-CoA synthetase medium-chain family member 2A -2.20965
OSBPL10 oxysterol binding protein-like 10 -2.2087
H1-2 H1.2 linker histone, cluster member -2.20835
TMCC1 transmembrane and coiled-coil domain family 1 -2.20788
FZD4 frizzled class receptor 4 -2.19925
RAD50 RAD50 homolog (S. cerevisiae) -2.19645
RNF123 ring finger protein 123 -2.1958
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.1957
MARCHF2 membrane associated ring-CH-type finger 2 -2.1939
ASCC3 activating signal cointegrator 1 complex subunit 3 -2.19285
CSPG4 chondroitin sulfate proteoglycan 4 -2.1916
RARG retinoic acid receptor, gamma -2.16185
MID2 midline 2 -2.15972
FGF18 fibroblast growth factor 18 -2.15103
ACADL acyl-CoA dehydrogenase, long chain -2.1436
CUX1 cut-like homeobox 1 -2.12952
RUSF1 RUS family member 1 -2.12225
AK4 adenylate kinase 4 -2.10997
TTPA tocopherol (alpha) transfer protein -2.10855
CNN3 calponin 3, acidic -2.10835
SYNJ2BP synaptojanin 2 binding protein -2.105
AQP9 aquaporin 9 -2.10335
OSBP2 oxysterol binding protein 2 -2.10045
ATF6 activating transcription factor 6 -2.09855
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1 -2.09635
ACOX2 acyl-CoA oxidase 2, branched chain -2.09245
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) -2.0911
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 -2.0877
MED22 mediator complex subunit 22 -2.08135
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 -2.0747
DCXR dicarbonyl/L-xylulose reductase -2.06985
ERC1 ELKS/RAB6-interacting/CAST family member 1 -2.06595
TRPM8 transient receptor potential cation channel, subfamily M, member 8 -2.0659
TSC22D3 TSC22 domain family, member 3 -2.06455
AHDC1 AT hook, DNA binding motif, containing 1 -2.06385
THAP11 THAP domain containing 11 -2.0615
CCN6 cellular communication network factor 6 -2.05965
DOK3 docking protein 3 -2.05905
PEX10 peroxisomal biogenesis factor 10 -2.05573
KCNK1 potassium channel, two pore domain subfamily K, member 1 -2.0537
TULP4 tubby like protein 4 -2.0504
SYNPO2L synaptopodin 2-like -2.05
RASA2 RAS p21 protein activator 2 -2.04695
CNOT3 CCR4-NOT transcription complex, subunit 3 -2.04535
TP73 tumor protein p73 -2.03955
TBC1D8B TBC1 domain family, member 8B (with GRAM domain) -2.03615
ERI3 ERI1 exoribonuclease family member 3 -2.0356
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa -2.03425
BPHL biphenyl hydrolase-like (serine hydrolase) -2.0324
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -2.03117
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.02995
MINPP1 multiple inositol-polyphosphate phosphatase 1 -2.0286
DRC11 dynein regulatory complex subunit 11 -2.0269
GPR161 G protein-coupled receptor 161 -2.01798
WDR7 WD repeat domain 7 -2.0159
HPR haptoglobin-related protein -2.01335
RHOBTB1 Rho-related BTB domain containing 1 -2.00635
ACOX1 acyl-CoA oxidase 1, palmitoyl -2.00593