CRCGN015_MCF10A.TP53.M_24H:N02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description propyleneimine 34.93 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

195 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:N02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 7.15191
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 5.5795
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.90381
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.84269
ABHD4 abhydrolase domain containing 4 4.80721
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 4.80123
CNRIP1 cannabinoid receptor interacting protein 1 4.72691
ADO 2-aminoethanethiol (cysteamine) dioxygenase 4.53669
PPARG peroxisome proliferator-activated receptor gamma 4.2582
GPER1 G protein-coupled estrogen receptor 1 4.17067
KIF5C kinesin family member 5C 4.04239
ABHD6 abhydrolase domain containing 6 3.97209
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 3.93399
SPAG4 sperm associated antigen 4 3.92133
IDE insulin-degrading enzyme 3.67926
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 3.60063
SSBP2 single-stranded DNA binding protein 2 3.26728
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.16959
CCL2 chemokine (C-C motif) ligand 2 3.02226
ZNF672 zinc finger protein 672 2.98257
SNX17 sorting nexin 17 2.96077
POLA2 polymerase (DNA directed), alpha 2, accessory subunit 2.92149
TBX2 T-box 2 2.86532
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 2.80535
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.79884
TSPAN8 tetraspanin 8 2.71056
BACE2 beta-site APP-cleaving enzyme 2 2.6982
CHN1 chimerin 1 2.68699
KDM5A lysine (K)-specific demethylase 5A 2.66603
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 2.62854
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit 2.61474
ADIPOR2 adiponectin receptor 2 2.6001
UBXN2B UBX domain protein 2B 2.58647
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 2.57065
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.56222
INTS6 integrator complex subunit 6 2.52268
MUL1 mitochondrial E3 ubiquitin protein ligase 1 2.52093
TP53I3 tumor protein p53 inducible protein 3 2.47579
AGBL5 ATP/GTP binding protein-like 5 2.46309
ARL4D ADP-ribosylation factor-like 4D 2.45128
HCFC2 host cell factor C2 2.43706
MEIS1 Meis homeobox 1 2.43585
MCUR1 mitochondrial calcium uniporter regulator 1 2.42724
FZD2 frizzled class receptor 2 2.41531
MSMB microseminoprotein, beta- 2.34642
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 2.33289
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 2.32553
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 2.32282
ITM2A integral membrane protein 2A 2.30019
NUBP2 nucleotide binding protein 2 2.28538
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa 2.27474
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.26453
BBS4 Bardet-Biedl syndrome 4 2.25593
NRBF2 nuclear receptor binding factor 2 2.23944
ROM1 retinal outer segment membrane protein 1 2.2317
PJA1 praja ring finger 1, E3 ubiquitin protein ligase 2.22814
CCT7 chaperonin containing TCP1, subunit 7 (eta) 2.21846
VCX3A variable charge, X-linked 3A 2.21713
MICALL1 MICAL-like 1 2.20992
MPV17 MpV17 mitochondrial inner membrane protein 2.20733
AP1B1 adaptor-related protein complex 1, beta 1 subunit 2.2043
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 2.1962
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.18334
ASXL1 additional sex combs like transcriptional regulator 1 2.14552
ODF2 outer dense fiber of sperm tails 2 2.14504
PTN pleiotrophin 2.11408
MACROH2A2 macroH2A.2 histone 2.08449
PRSS2 protease, serine, 2 (trypsin 2) 2.08278
RNF113A ring finger protein 113A 2.07251
EFNB2 ephrin-B2 2.07006
HAS2 hyaluronan synthase 2 2.06832
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 2.05527
ACTA2 actin, alpha 2, smooth muscle, aorta 2.05512
UFC1 ubiquitin-fold modifier conjugating enzyme 1 2.05288
CCDC169-SOHLH2 CCDC169-SOHLH2 readthrough 2.04505
TRAM1 translocation associated membrane protein 1 2.03815
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 2.02256
MACIR macrophage immunometabolism regulator 2.02183
CLK3 CDC-like kinase 3 2.01837
PAAF1 proteasomal ATPase-associated factor 1 2.01526
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 2.01349

decreased expression

Symbol Name Standardized Value
TXNDC9 thioredoxin domain containing 9 -9.48085
HMG20B high mobility group 20B -9.28419
DSG2 desmoglein 2 -5.10026
CD320 CD320 molecule -5.06551
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -4.98445
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -4.88316
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -4.43568
VDAC1 voltage-dependent anion channel 1 -4.35171
GRN granulin -4.29535
HAT1 histone acetyltransferase 1 -4.26342
C2CD5 C2 calcium-dependent domain containing 5 -3.98134
MTERF3 mitochondrial transcription termination factor 3 -3.94324
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.87559
TMEM131 transmembrane protein 131 -3.74393
PTK2 protein tyrosine kinase 2 -3.69297
FOS FBJ murine osteosarcoma viral oncogene homolog -3.47676
PDCL3 phosducin-like 3 -3.41178
ATF5 activating transcription factor 5 -3.29491
PFN1 profilin 1 -3.21273
ZNF146 zinc finger protein 146 -3.15988
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria -3.13612
REV1 REV1, polymerase (DNA directed) -3.12692
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.11998
UXS1 UDP-glucuronate decarboxylase 1 -3.01365
PROM1 prominin 1 -2.97055
UNC50 unc-50 homolog (C. elegans) -2.96668
MFSD12 major facilitator superfamily domain containing 12 -2.96637
CLDN3 claudin 3 -2.96517
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) -2.96505
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.95384
MZT2A mitotic spindle organizing protein 2A -2.94893
KHDC1L KH homology domain containing 1-like -2.88485
COX6C cytochrome c oxidase subunit VIc -2.86529
MERTK MER proto-oncogene, tyrosine kinase -2.84723
BMX BMX non-receptor tyrosine kinase -2.79025
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 -2.78921
EIF5B eukaryotic translation initiation factor 5B -2.77047
LIPT1 lipoyltransferase 1 -2.72088
LEFTY1 left-right determination factor 1 -2.68921
ZNF514 zinc finger protein 514 -2.65311
SF3A2 splicing factor 3a, subunit 2, 66kDa -2.6487
TWF2 twinfilin actin binding protein 2 -2.62498
ZNF250 zinc finger protein 250 -2.51925
S100A1 S100 calcium binding protein A1 -2.51718
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 -2.49481
COX5B cytochrome c oxidase subunit Vb -2.48097
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma -2.47417
CXCL14 chemokine (C-X-C motif) ligand 14 -2.46972
IL12RB2 interleukin 12 receptor, beta 2 -2.46143
ZNF544 zinc finger protein 544 -2.4494
TBCB tubulin folding cofactor B -2.44705
PIBF1 progesterone immunomodulatory binding factor 1 -2.42253
ABHD11 abhydrolase domain containing 11 -2.42077
GCC2 GRIP and coiled-coil domain containing 2 -2.3828
ECI1 enoyl-CoA delta isomerase 1 -2.38213
SARS2 seryl-tRNA synthetase 2, mitochondrial -2.37915
NFE2L3 nuclear factor, erythroid 2-like 3 -2.36186
PTPRD protein tyrosine phosphatase, receptor type, D -2.35985
OLA1 Obg-like ATPase 1 -2.34522
SGK1 serum/glucocorticoid regulated kinase 1 -2.34155
WIPI1 WD repeat domain, phosphoinositide interacting 1 -2.33892
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator -2.32484
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) -2.32161
RANBP2 RAN binding protein 2 -2.31134
TGFBRAP1 transforming growth factor, beta receptor associated protein 1 -2.30466
OPLAH 5-oxoprolinase (ATP-hydrolysing) -2.30397
ORC4 origin recognition complex, subunit 4 -2.28851
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 -2.27016
ATP5MC3 ATP synthase membrane subunit c locus 3 -2.26782
ZNF573 zinc finger protein 573 -2.26627
SSB Sjogren syndrome antigen B (autoantigen La) -2.26334
CBR3 carbonyl reductase 3 -2.2593
STARD7 StAR-related lipid transfer (START) domain containing 7 -2.25872
SCGB2A1 secretoglobin, family 2A, member 1 -2.25326
ZC3H3 zinc finger CCCH-type containing 3 -2.25086
COQ10B coenzyme Q10 homolog B (S. cerevisiae) -2.25084
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase -2.24391
TUBA4A tubulin, alpha 4a -2.23894
YIPF3 Yip1 domain family, member 3 -2.22952
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -2.21826
MZT2B mitotic spindle organizing protein 2B -2.21327
ATP5F1E ATP synthase F1 subunit epsilon -2.20493
FPGS folylpolyglutamate synthase -2.20191
NANS N-acetylneuraminic acid synthase -2.20106
KLF11 Kruppel-like factor 11 -2.19105
L1TD1 LINE-1 type transposase domain containing 1 -2.18941
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -2.18155
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 -2.1805
SLIRP SRA stem-loop interacting RNA binding protein -2.17039
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain -2.17037
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein -2.16364
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa -2.14735
GID8 GID complex subunit 8 -2.1463
METTL5 methyltransferase like 5 -2.13916
RAI2 retinoic acid induced 2 -2.13825
TNF tumor necrosis factor -2.13179
XKR8 XK, Kell blood group complex subunit-related family, member 8 -2.12611
CX3CL1 chemokine (C-X3-C motif) ligand 1 -2.11046
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7 -2.10504
CDC34 cell division cycle 34 -2.10258
TMEM127 transmembrane protein 127 -2.09722
CRIPTO3 cripto, EGF-CFC family member 3 -2.09602
A2M alpha-2-macroglobulin -2.08895
LMAN2L lectin, mannose-binding 2-like -2.08489
DCAF6 DDB1 and CUL4 associated factor 6 -2.07492
TTPA tocopherol (alpha) transfer protein -2.06134
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 -2.04712
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C -2.0306
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa -2.0281
ADRM1 adhesion regulating molecule 1 -2.01782
ECM1 extracellular matrix protein 1 -2.01358
LIN37 lin-37 DREAM MuvB core complex component -2.01325
GIPC2 GIPC PDZ domain containing family, member 2 -2.00677
THNSL2 threonine synthase-like 2 (S. cerevisiae) -2.00628