CRCGN015_MCF10A.TP53.M_24H:N06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description naphthalene 11.03 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

38 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:N06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 5.5452
PEX11A peroxisomal biogenesis factor 11 alpha 4.99928
SSBP2 single-stranded DNA binding protein 2 4.72672
OXSR1 oxidative stress responsive 1 4.59
KIF5C kinesin family member 5C 4.34137
SYNGAP1 synaptic Ras GTPase activating protein 1 3.68357
ACAA1 acetyl-CoA acyltransferase 1 3.52793
STK10 serine/threonine kinase 10 2.4263
FJX1 four jointed box 1 (Drosophila) 2.3352
COL15A1 collagen, type XV, alpha 1 2.2459
NOSIP nitric oxide synthase interacting protein 2.14505
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.09995
JAK1 Janus kinase 1 2.0594
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.0221
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8 2.0196
ACSS3 acyl-CoA synthetase short-chain family member 3 2.01395

decreased expression

Symbol Name Standardized Value
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.8828
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -4.09352
BPHL biphenyl hydrolase-like (serine hydrolase) -3.862
HOXA5 homeobox A5 -3.6917
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.62285
ELAC2 elaC ribonuclease Z 2 -3.38745
RBM34 RNA binding motif protein 34 -3.00847
FPGS folylpolyglutamate synthase -2.8912
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -2.46735
ACOT13 acyl-CoA thioesterase 13 -2.4426
GGPS1 geranylgeranyl diphosphate synthase 1 -2.4187
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 -2.40755
CRTAP cartilage associated protein -2.35425
MTERF3 mitochondrial transcription termination factor 3 -2.32625
RPS5 ribosomal protein S5 -2.3234
CD81 CD81 molecule -2.2779
LARP7 La ribonucleoprotein domain family, member 7 -2.18235
EXOSC9 exosome component 9 -2.1213
TNFAIP8L2-SCNM1 TNFAIP8L2-SCNM1 readthrough -2.1047
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.10215
INTS5 integrator complex subunit 5 -2.0639
STYXL1 serine/threonine/tyrosine interacting-like 1 -2.045