CRCGN015_MCF10A.TP53.M_24H:N10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tetranitromethane 101.3 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

121 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:N10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 5.0
PEX11A peroxisomal biogenesis factor 11 alpha 4.9927
CARMIL1 capping protein regulator and myosin 1 linker 1 4.9187
MAMLD1 mastermind-like domain containing 1 4.6215
CCNA1 cyclin A1 4.47025
GPER1 G protein-coupled estrogen receptor 1 4.36582
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.0653
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 3.98315
ACAA1 acetyl-CoA acyltransferase 1 3.47052
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 3.03975
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.78415
GPATCH8 G patch domain containing 8 2.71435
CNRIP1 cannabinoid receptor interacting protein 1 2.6774
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor 2.6723
NEIL3 nei endonuclease VIII-like 3 (E. coli) 2.5816
COMP cartilage oligomeric matrix protein 2.55025
ELOVL2 ELOVL fatty acid elongase 2 2.51848
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.51795
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene) 2.50415
JTB jumping translocation breakpoint 2.44778
AUNIP aurora kinase A and ninein interacting protein 2.3976
DNA2 DNA replication helicase/nuclease 2 2.3228
SPC25 SPC25, NDC80 kinetochore complex component 2.30515
TM2D3 TM2 domain containing 3 2.2907
CD5 CD5 molecule 2.26775
SRFBP1 serum response factor binding protein 1 2.26245
NDP Norrie disease (pseudoglioma) 2.25715
SMG5 SMG5 nonsense mediated mRNA decay factor 2.24808
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4 2.19945
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 2.19285
GGCT gamma-glutamylcyclotransferase 2.1858
TDG thymine-DNA glycosylase 2.18315
UBP1 upstream binding protein 1 (LBP-1a) 2.15195
LSR lipolysis stimulated lipoprotein receptor 2.1438
RAD51D RAD51 paralog D 2.14165
CHI3L2 chitinase 3-like 2 2.13515
ZNF783 zinc finger family member 783 2.13385
NAT9 N-acetyltransferase 9 (GCN5-related, putative) 2.11615
BICRA BRD4 interacting chromatin remodeling complex associated protein 2.10325
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 2.10015
TOMM6 translocase of outer mitochondrial membrane 6 homolog (yeast) 2.0974
VPS33B vacuolar protein sorting 33 homolog B (yeast) 2.07755
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 2.0749
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 2.06145
CIB1 calcium and integrin binding 1 (calmyrin) 2.0577
S100A10 S100 calcium binding protein A10 2.04615
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing 2.0409
KYAT1 kynurenine aminotransferase 1 2.03665
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 2.0335
PLS3 plastin 3 2.03055
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 2.0142

decreased expression

Symbol Name Standardized Value
COG7 component of oligomeric golgi complex 7 -5.9968
TEX10 testis expressed 10 -5.22185
CDC20 cell division cycle 20 -4.99965
HMG20B high mobility group 20B -4.34142
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.8071
STAT1 signal transducer and activator of transcription 1, 91kDa -3.7825
TRAPPC8 trafficking protein particle complex 8 -3.13175
SCNN1B sodium channel, non voltage gated 1 beta subunit -2.97405
KRT14 keratin 14, type I -2.96505
FAIM Fas apoptotic inhibitory molecule -2.87115
UBFD1 ubiquitin family domain containing 1 -2.7814
LOC124900388 uncharacterized LOC124900388 -2.64035
NDE1 nudE neurodevelopment protein 1 -2.6328
SPATS2 spermatogenesis associated, serine-rich 2 -2.6108
SORBS3 sorbin and SH3 domain containing 3 -2.55833
KLRB1 killer cell lectin-like receptor subfamily B, member 1 -2.5572
RNF125 ring finger protein 125, E3 ubiquitin protein ligase -2.54355
RAP2A RAP2A, member of RAS oncogene family -2.53395
CCDC81 coiled-coil domain containing 81 -2.4986
REEP5 receptor accessory protein 5 -2.4607
VPREB1 pre-B lymphocyte 1 -2.44435
SGK1 serum/glucocorticoid regulated kinase 1 -2.4323
VASP vasodilator-stimulated phosphoprotein -2.42385
TRIM58 tripartite motif containing 58 -2.3978
IL10RB interleukin 10 receptor, beta -2.3928
HIRIP3 HIRA interacting protein 3 -2.3891
REL v-rel avian reticuloendotheliosis viral oncogene homolog -2.3748
TXNDC15 thioredoxin domain containing 15 -2.36935
PRDM1 PR domain containing 1, with ZNF domain -2.35695
DNTT DNA nucleotidylexotransferase -2.3347
MTERF3 mitochondrial transcription termination factor 3 -2.3204
DCAF16 DDB1 and CUL4 associated factor 16 -2.31635
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -2.29625
TRIM56 tripartite motif containing 56 -2.29335
POU2F1 POU class 2 homeobox 1 -2.2802
TEX11 testis expressed 11 -2.2796
AHSP alpha hemoglobin stabilizing protein -2.2679
CRABP1 cellular retinoic acid binding protein 1 -2.26545
LCMT1 leucine carboxyl methyltransferase 1 -2.2627
DNAH3 dynein, axonemal, heavy chain 3 -2.2471
NLRP1 NLR family, pyrin domain containing 1 -2.24115
NAIP NLR family, apoptosis inhibitory protein -2.224
NPIPA6 nuclear pore complex interacting protein family, member A6 -2.19165
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -2.18785
SLAMF7 SLAM family member 7 -2.18755
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 -2.16663
BCL7C B-cell CLL/lymphoma 7C -2.14585
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 -2.14048
ERO1B endoplasmic reticulum oxidoreductase 1 beta -2.13835
GPR15 G protein-coupled receptor 15 -2.11935
CD53 CD53 molecule -2.11885
ARHGAP25 Rho GTPase activating protein 25 -2.11107
AMPD1 adenosine monophosphate deaminase 1 -2.1048
DCTN5 dynactin 5 (p25) -2.09097
XK X-linked Kx blood group -2.07835
LSP1 lymphocyte-specific protein 1 -2.0687
PGAP4 post-GPI attachment to proteins GalNAc transferase 4 -2.0556
RIGI RNA sensor RIG-I -2.05375
PTGDR prostaglandin D2 receptor (DP) -2.04715
ALAS2 5'-aminolevulinate synthase 2 -2.0463
IRF9 interferon regulatory factor 9 -2.0403
PRTN3 proteinase 3 -2.03565
PLVAP plasmalemma vesicle associated protein -2.0335
GCG glucagon -2.02185
OSBPL8 oxysterol binding protein-like 8 -2.02128
RUSF1 RUS family member 1 -2.02007
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.0176
STX17 syntaxin 17 -2.01755
MGMT O-6-methylguanine-DNA methyltransferase -2.0074
AMZ2 archaelysin family metallopeptidase 2 -2.00385