CRCGN015_MCF10A.TP53.M_24H:N11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tetranitromethane 33.77 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

63 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:N11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 5.2142
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.60315
BDH1 3-hydroxybutyrate dehydrogenase, type 1 3.98905
SQOR sulfide quinone oxidoreductase 3.2845
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.0462
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.93525
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.78595
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.50095
SPDEF SAM pointed domain containing ETS transcription factor 2.48333
CNRIP1 cannabinoid receptor interacting protein 1 2.31015
COPS7A COP9 signalosome subunit 7A 2.26215
NFIL3 nuclear factor, interleukin 3 regulated 2.1746
RFX5 regulatory factor X, 5 (influences HLA class II expression) 2.11368
PEX13 peroxisomal biogenesis factor 13 2.10115
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 2.0892
GSTZ1 glutathione S-transferase zeta 1 2.0595

decreased expression

Symbol Name Standardized Value
TRAPPC3 trafficking protein particle complex 3 -5.30713
RNF167 ring finger protein 167 -5.21675
GRN granulin -5.10953
MAPK13 mitogen-activated protein kinase 13 -4.61462
YME1L1 YME1-like 1 ATPase -4.49055
EPN2 epsin 2 -4.18175
TUBA4A tubulin, alpha 4a -4.15055
ABI1 abl-interactor 1 -3.42248
BASP1 brain abundant, membrane attached signal protein 1 -3.2827
CDK4 cyclin-dependent kinase 4 -3.15755
SORBS3 sorbin and SH3 domain containing 3 -3.1508
ACAA1 acetyl-CoA acyltransferase 1 -3.06892
MRPS15 mitochondrial ribosomal protein S15 -2.7344
RGS2 regulator of G-protein signaling 2 -2.6987
CPTP ceramide-1-phosphate transfer protein -2.4899
CD320 CD320 molecule -2.45835
CRCT1 cysteine-rich C-terminal 1 -2.3961
PKP3 plakophilin 3 -2.37897
CRNN cornulin -2.2281
ENDOU endonuclease, polyU-specific -2.22165
MSMO1 methylsterol monooxygenase 1 -2.21605
KLK13 kallikrein-related peptidase 13 -2.2156
GAL3ST4 galactose-3-O-sulfotransferase 4 -2.2059
EIF5 eukaryotic translation initiation factor 5 -2.20028
ADRA2B adrenoceptor alpha 2B -2.18845
ZNF248 zinc finger protein 248 -2.1827
REXO2 RNA exonuclease 2 -2.18174
CLPTM1 cleft lip and palate associated transmembrane protein 1 -2.1481
ACSF2 acyl-CoA synthetase family member 2 -2.1479
DNALI1 dynein, axonemal, light intermediate chain 1 -2.1338
GLRB glycine receptor, beta -2.10127
TGM1 transglutaminase 1 -2.0769
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa -2.07535
CLDN4 claudin 4 -2.07475
SEPHS2 selenophosphate synthetase 2 -2.05795
PLD2 phospholipase D2 -2.0523
CLDN7 claudin 7 -2.0422
ZNF14 zinc finger protein 14 -2.0384
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 -2.0335
PDK2 pyruvate dehydrogenase kinase, isozyme 2 -2.03085
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa -2.026
PAX6 paired box 6 -2.02115
MAVS mitochondrial antiviral signaling protein -2.0205
TRAF4 TNF receptor-associated factor 4 -2.01937
UBTD1 ubiquitin domain containing 1 -2.01165
CLSTN3 calsyntenin 3 -2.00775
DHRS1 dehydrogenase/reductase (SDR family) member 1 -2.00335