CRCGN015_MCF10A.TP53.M_24H:N13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cobalt sulfate heptahydrate 100.3 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

68 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:N13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ALDOC aldolase C, fructose-bisphosphate 6.68925
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 5.3659
TSEN2 TSEN2 tRNA splicing endonuclease subunit 4.82985
MAMLD1 mastermind-like domain containing 1 4.77405
GATA2 GATA binding protein 2 4.2647
HBB hemoglobin, beta 3.61137
MMP1 matrix metallopeptidase 1 3.51013
CNRIP1 cannabinoid receptor interacting protein 1 3.3303
HBA1 hemoglobin, alpha 1 3.30633
CRELD2 cysteine-rich with EGF-like domains 2 2.80515
TBC1D31 TBC1 domain family, member 31 2.76175
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 2.70385
BZW2 basic leucine zipper and W2 domains 2 2.5284
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 2.5241
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.3484
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 2.33755
CPA4 carboxypeptidase A4 2.31355
DENND2D DENN/MADD domain containing 2D 2.2868
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 2.2483
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.20255
WFDC1 WAP four-disulfide core domain 1 2.1822
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.1546
LGMN legumain 2.147
CHN1 chimerin 1 2.11425
CSAG2 CSAG family, member 2 2.09045
SSUH2 ssu-2 homolog (C. elegans) 2.07955
LOC112694756 uncharaterized LOC112694756 2.07675
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide 2.0734
BRD9 bromodomain containing 9 2.06595
IL5 interleukin 5 2.0586
LARP1 La ribonucleoprotein domain family, member 1 2.05635
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.0546

decreased expression

Symbol Name Standardized Value
TRAPPC3 trafficking protein particle complex 3 -5.40128
COG2 component of oligomeric golgi complex 2 -5.2646
KIF14 kinesin family member 14 -5.14685
LDHD lactate dehydrogenase D -4.3381
ANKRD10 ankyrin repeat domain 10 -3.52105
ERC2 ELKS/RAB6-interacting/CAST family member 2 -3.31567
ACAA1 acetyl-CoA acyltransferase 1 -3.23438
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase -3.10775
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -3.03375
MRPS15 mitochondrial ribosomal protein S15 -2.96455
ACSF2 acyl-CoA synthetase family member 2 -2.80975
COTL1 coactosin-like F-actin binding protein 1 -2.7697
PCCB propionyl CoA carboxylase, beta polypeptide -2.7064
CD320 CD320 molecule -2.7056
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase -2.63925
BCAP29 B-cell receptor-associated protein 29 -2.59355
HOXA7 homeobox A7 -2.5722
COG5 component of oligomeric golgi complex 5 -2.53377
MTERF3 mitochondrial transcription termination factor 3 -2.493
MPC2 mitochondrial pyruvate carrier 2 -2.35905
SRPK2 SRSF protein kinase 2 -2.35658
FBXO3 F-box protein 3 -2.31245
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.28775
BAX BCL2-associated X protein -2.23285
DEXI Dexi homolog (mouse) -2.226
CBR3 carbonyl reductase 3 -2.22505
COPS6 COP9 signalosome subunit 6 -2.20123
C1S complement component 1, s subcomponent -2.1697
CHD1 chromodomain helicase DNA binding protein 1 -2.1508
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -2.11545
TOR1A torsin family 1, member A (torsin A) -2.10938
RINT1 RAD50 interactor 1 -2.10775
RPIA ribose 5-phosphate isomerase A -2.0979
LIG4 ligase IV, DNA, ATP-dependent -2.0736
MRPS33 mitochondrial ribosomal protein S33 -2.0706
SLC35F6 solute carrier family 35, member F6 -2.0106