CRCGN015_MCF10A.TP53.M_24H:N14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cobalt sulfate heptahydrate 33.43 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

28 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:N14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GATA3 GATA binding protein 3 5.37287
ACAA1 acetyl-CoA acyltransferase 1 3.53545
AGR2 anterior gradient 2 2.9917
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.94561
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 2.67318
ECH1 enoyl CoA hydratase 1, peroxisomal 2.4633
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 2.39045
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 2.35505
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.25985
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.2202

decreased expression

Symbol Name Standardized Value
TM9SF3 transmembrane 9 superfamily member 3 -5.6316
DYNLT3 dynein, light chain, Tctex-type 3 -5.2897
DIPK1A divergent protein kinase domain 1A -5.11557
VAT1 vesicle amine transport 1 -4.86725
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.4125
NLRP4 NLR family, pyrin domain containing 4 -3.6363
NUSAP1 nucleolar and spindle associated protein 1 -3.53997
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.56675
NR1I3 nuclear receptor subfamily 1, group I, member 3 -2.25125
FAM110A family with sequence similarity 110, member A -2.2112
FETUB fetuin B -2.1777
LTC4S leukotriene C4 synthase -2.1522
RASAL1 RAS protein activator like 1 (GAP1 like) -2.102
MNS1 meiosis-specific nuclear structural 1 -2.0948
MTFR1 mitochondrial fission regulator 1 -2.0783
TLR3 toll-like receptor 3 -2.0699
TENT4A terminal nucleotidyltransferase 4A -2.04445
SGK1 serum/glucocorticoid regulated kinase 1 -2.02645