CRCGN015_MCF10A.TP53.M_24H:N15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cobalt sulfate heptahydrate 11.14 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

47 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:N15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TLR4 toll-like receptor 4 5.33725
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 3.47757
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 3.07837
GSTZ1 glutathione S-transferase zeta 1 2.8626
NFIL3 nuclear factor, interleukin 3 regulated 2.83645
FPR2 formyl peptide receptor 2 2.83045
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 2.7756
COMP cartilage oligomeric matrix protein 2.588
GASK1B golgi associated kinase 1B 2.5493
LSR lipolysis stimulated lipoprotein receptor 2.5175
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.5017
UBE2D1 ubiquitin-conjugating enzyme E2D 1 2.47188
AOAH acyloxyacyl hydrolase (neutrophil) 2.3949
MNDA myeloid cell nuclear differentiation antigen 2.3893
EIF5A2 eukaryotic translation initiation factor 5A2 2.34095
CD1D CD1d molecule 2.32415
TLR1 toll-like receptor 1 2.2863
TGFB2 transforming growth factor, beta 2 2.2547
NOSIP nitric oxide synthase interacting protein 2.2465
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 2.2448
ESRP2 epithelial splicing regulatory protein 2 2.15285
RBL1 retinoblastoma-like 1 2.14615
TLR8 toll-like receptor 8 2.13415
TTC27 tetratricopeptide repeat domain 27 2.12525
CTSS cathepsin S 2.11305
ARL14 ADP-ribosylation factor-like 14 2.1116
TLCD3A TLC domain containing 3A 2.1116
CLEC4A C-type lectin domain family 4, member A 2.09305
DMAC2L distal membrane arm assembly component 2 like 2.01218

decreased expression

Symbol Name Standardized Value
SLC25A46 solute carrier family 25, member 46 -5.2681
HMG20B high mobility group 20B -4.80243
GNAS GNAS complex locus -4.39444
LYPLA1 lysophospholipase I -4.25047
HSPA1A heat shock 70kDa protein 1A -3.04635
SGK1 serum/glucocorticoid regulated kinase 1 -2.9368
KCNK1 potassium channel, two pore domain subfamily K, member 1 -2.66937
RPA3 replication protein A3, 14kDa -2.6321
ATP5F1E ATP synthase F1 subunit epsilon -2.60945
RFC2 replication factor C (activator 1) 2, 40kDa -2.4525
GOLGA7 golgin A7 -2.42375
PABPC1 poly(A) binding protein, cytoplasmic 1 -2.3168
LYPLA1-TCEA1 LYPLA1-TCEA1 readthrough -2.24645
HINT1 histidine triad nucleotide binding protein 1 -2.06357
PJA1 praja ring finger 1, E3 ubiquitin protein ligase -2.0426
SH3GLB2 SH3-domain GRB2-like endophilin B2 -2.0395
TUBA1C tubulin, alpha 1c -2.02168
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -2.0204