CRCGN015_MCF10A.TP53.M_24H:N16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,2-epoxybutane 97.3 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

44 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:N16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 5.2399
H2BC21 H2B clustered histone 21 4.6431
GET1 guided entry of tail-anchored proteins factor 1 4.52365
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 3.95375
GADD45A growth arrest and DNA-damage-inducible, alpha 3.6307
SOX2 SRY (sex determining region Y)-box 2 3.62248
GARRE1 granule associated Rac and RHOG effector 1 3.0967
PRKCQ protein kinase C, theta 2.9303
TBC1D31 TBC1 domain family, member 31 2.847
CFAP298 cilia and flagella associated protein 298 2.816
NUP133 nucleoporin 133kDa 2.6849
PHKG2 phosphorylase kinase, gamma 2 (testis) 2.47845
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.4699
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.371
TMEM94 transmembrane protein 94 2.2551
SPDEF SAM pointed domain containing ETS transcription factor 2.19862
LZTFL1 leucine zipper transcription factor-like 1 2.1973
CCNA1 cyclin A1 2.14175
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.11675
IGFBP3 insulin-like growth factor binding protein 3 2.0985
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.07823
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 2.02305
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35 2.0159
PECR peroxisomal trans-2-enoyl-CoA reductase 2.00155
PHF2 PHD finger protein 2 2.0011

decreased expression

Symbol Name Standardized Value
DCK deoxycytidine kinase -5.02015
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.66275
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -4.3117
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa -2.66235
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal -2.5557
UNKL unkempt family zinc finger-like -2.51635
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12) -2.45765
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.4266
TSR3 TSR3, 20S rRNA accumulation, homolog (S. cerevisiae) -2.42255
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 -2.3823
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 -2.25915
CRBN cereblon -2.2356
CD320 CD320 molecule -2.1819
CASP8AP2 caspase 8 associated protein 2 -2.1574
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) -2.1501
ZNF263 zinc finger protein 263 -2.1384
OGFRL1 opioid growth factor receptor-like 1 -2.1354
ZMYM2 zinc finger, MYM-type 2 -2.10893
RHOT2 ras homolog family member T2 -2.0551