CRCGN015_MCF10A.TP53.M_24H:N17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,2-epoxybutane 32.43 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

52 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:N17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ACAA1 acetyl-CoA acyltransferase 1 6.8187
MMP1 matrix metallopeptidase 1 4.88025
GET1 guided entry of tail-anchored proteins factor 1 4.4815
DENND2D DENN/MADD domain containing 2D 4.1207
CHN1 chimerin 1 3.3839
MCUR1 mitochondrial calcium uniporter regulator 1 2.884
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.8626
CCNA1 cyclin A1 2.8245
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.8133
ENOPH1 enolase-phosphatase 1 2.7828
ENOSF1 enolase superfamily member 1 2.77358
MMP2 matrix metallopeptidase 2 2.595
PIH1D1 PIH1 domain containing 1 2.5903
LSR lipolysis stimulated lipoprotein receptor 2.5166
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.4714
H2AZ2 H2A.Z variant histone 2 2.44737
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.3402
NOP14 NOP14 nucleolar protein 2.237
EMC6 ER membrane protein complex subunit 6 2.2107
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.1684
TGFB3 transforming growth factor, beta 3 2.1631
PAK1IP1 PAK1 interacting protein 1 2.1595
G0S2 G0/G1 switch 2 2.1251
TBC1D31 TBC1 domain family, member 31 2.113
SYNGR3 synaptogyrin 3 2.0545

decreased expression

Symbol Name Standardized Value
STXBP2 syntaxin binding protein 2 -7.6059
MTERF3 mitochondrial transcription termination factor 3 -5.9916
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -4.47445
RPS5 ribosomal protein S5 -3.859
PRCP prolylcarboxypeptidase (angiotensinase C) -3.224
ILK integrin-linked kinase -2.6471
DRC4 dynein regulatory complex subunit 4 -2.5535
POGLUT1 protein O-glucosyltransferase 1 -2.423
BCORL1 BCL6 corepressor-like 1 -2.4135
APOD apolipoprotein D -2.3298
OR10H1 olfactory receptor, family 10, subfamily H, member 1 -2.3053
MUC5B mucin 5B, oligomeric mucus/gel-forming -2.2773
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 -2.2599
RPL10A ribosomal protein L10a -2.2599
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -2.242
CSNK1A1 casein kinase 1, alpha 1 -2.20407
ZNF638 zinc finger protein 638 -2.184
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -2.1784
STX1A syntaxin 1A (brain) -2.1664
NGB neuroglobin -2.1331
TXNRD3 thioredoxin reductase 3 -2.1201
ZNF358 zinc finger protein 358 -2.0933
PADI2 peptidyl arginine deiminase, type II -2.0921
RPL29 ribosomal protein L29 -2.0438
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4 -2.0241
OR1F1 olfactory receptor, family 1, subfamily F, member 1 -2.0212
TRPM2 transient receptor potential cation channel, subfamily M, member 2 -2.0206