CRCGN015_MCF10A.TP53.M_24H:N20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

55 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:N20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
FKBP14 FK506 binding protein 14, 22 kDa 4.9564
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 4.85135
CHMP6 charged multivesicular body protein 6 4.2263
FGFR4 fibroblast growth factor receptor 4 3.92263
TIAM1 T-cell lymphoma invasion and metastasis 1 3.7961
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 3.7049
TOMM34 translocase of outer mitochondrial membrane 34 3.4326
KDM5D lysine (K)-specific demethylase 5D 2.832
NVL nuclear VCP-like 2.8244
BPHL biphenyl hydrolase-like (serine hydrolase) 2.74565
USP9Y ubiquitin specific peptidase 9, Y-linked 2.66645
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.50425
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.43388
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 2.41115
CENPE centromere protein E, 312kDa 2.38045
IL10RA interleukin 10 receptor, alpha 2.36525
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.3489
PECR peroxisomal trans-2-enoyl-CoA reductase 2.29985
HYOU1 hypoxia up-regulated 1 2.2666
MMP2 matrix metallopeptidase 2 2.26345
FIRRM FIGNL1 interacting regulator of recombination and mitosis 2.1908
AURKB aurora kinase B 2.17025
MIS18A MIS18 kinetochore protein A 2.167
ASGR1 asialoglycoprotein receptor 1 2.1127
VANGL1 VANGL planar cell polarity protein 1 2.08145
TRAPPC6A trafficking protein particle complex 6A 2.06325
PMCH pro-melanin-concentrating hormone 2.0529
HACD3 3-hydroxyacyl-CoA dehydratase 3 2.03245
GSTZ1 glutathione S-transferase zeta 1 2.01405
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase 2.0067

decreased expression

Symbol Name Standardized Value
CD81 CD81 molecule -5.22645
RPS5 ribosomal protein S5 -4.50075
ANKRD10 ankyrin repeat domain 10 -4.21995
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -3.64685
THAP11 THAP domain containing 11 -3.57265
CD320 CD320 molecule -3.4892
SMC1A structural maintenance of chromosomes 1A -3.42257
BASP1 brain abundant, membrane attached signal protein 1 -3.09985
ZMYM2 zinc finger, MYM-type 2 -2.95645
RPA3 replication protein A3, 14kDa -2.9041
CBR3 carbonyl reductase 3 -2.76095
KDM5C lysine (K)-specific demethylase 5C -2.4392
CRTAP cartilage associated protein -2.4126
USP9X ubiquitin specific peptidase 9, X-linked -2.38762
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.27358
RPS29 ribosomal protein S29 -2.1497
RPS12 ribosomal protein S12 -2.11135
IRS2 insulin receptor substrate 2 -2.0429
ARGLU1 arginine and glutamate rich 1 -2.0372
COMMD1 copper metabolism (Murr1) domain containing 1 -2.02695
RPL18 ribosomal protein L18 -2.02285
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) -2.01395
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -2.00825
PUDP pseudouridine 5'-phosphatase -2.00795
KAT7 K(lysine) acetyltransferase 7 -2.00345