CRCGN015_MCF10A.TP53.M_24H:N21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

192 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:N21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STIMATE STIM activating enhancer 10.0
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 10.0
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 7.17165
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 4.9121
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 4.8709
MELK maternal embryonic leucine zipper kinase 3.6399
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 3.5883
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 3.4321
CAPN1 calpain 1, (mu/I) large subunit 3.3908
PDLIM1 PDZ and LIM domain 1 3.3459
C2CD2 C2 calcium-dependent domain containing 2 3.2247
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 3.2234
MNDA myeloid cell nuclear differentiation antigen 3.1383
HEMK2 HemK methyltransferase 2, ETF1 glutamine and histone H4 lysine 3.0984
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.7949
TMEM106B transmembrane protein 106B 2.7525
ZNF207 zinc finger protein 207 2.62545
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.6185
SLC30A1 solute carrier family 30 (zinc transporter), member 1 2.5995
EMC8 ER membrane protein complex subunit 8 2.5969
IMP4 IMP4, U3 small nucleolar ribonucleoprotein 2.5886
MMP2 matrix metallopeptidase 2 2.5801
SRSF4 serine/arginine-rich splicing factor 4 2.5735
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 2.5605
XAF1 XIAP associated factor 1 2.504
NRTN neurturin 2.495
TMEM50B transmembrane protein 50B 2.4349
GIN1 gypsy retrotransposon integrase 1 2.4323
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 2.4191
CYB5B cytochrome b5 type B (outer mitochondrial membrane) 2.4072
CYBB cytochrome b-245, beta polypeptide 2.40135
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 2.339
PIM2 Pim-2 proto-oncogene, serine/threonine kinase 2.3161
CCNB1 cyclin B1 2.3153
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) 2.3011
LY6E lymphocyte antigen 6 complex, locus E 2.28
CDK8 cyclin-dependent kinase 8 2.2684
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 2.2487
MX2 MX dynamin-like GTPase 2 2.2415
TRIT1 tRNA isopentenyltransferase 1 2.2273
GOLT1B golgi transport 1B 2.2196
CSNK1G3 casein kinase 1, gamma 3 2.2155
CCNE1 cyclin E1 2.2134
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit 2.2013
NR2F1 nuclear receptor subfamily 2, group F, member 1 2.18765
KLRB1 killer cell lectin-like receptor subfamily B, member 1 2.1823
CASP1 caspase 1, apoptosis-related cysteine peptidase 2.16998
STARD7 StAR-related lipid transfer (START) domain containing 7 2.1688
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.1634
CRLF3 cytokine receptor-like factor 3 2.1619
UPK1A uroplakin 1A 2.1364
ALG11 ALG11, alpha-1,2-mannosyltransferase 2.1359
CPOX coproporphyrinogen oxidase 2.1293
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.1229
ADIRF adipogenesis regulatory factor 2.115
WDR12 WD repeat domain 12 2.1084
IGF2 insulin-like growth factor 2 2.1027
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 2.1021
GPKOW G patch domain and KOW motifs 2.0969
UGDH UDP-glucose 6-dehydrogenase 2.0933
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A 2.0925
MOB4 MOB family member 4, phocein 2.08055
KAT2B K(lysine) acetyltransferase 2B 2.0676
ISL1 ISL LIM homeobox 1 2.0569
TMEM248 transmembrane protein 248 2.0487
IL10RA interleukin 10 receptor, alpha 2.0455
VTI1B vesicle transport through interaction with t-SNAREs 1B 2.0115
ADAR adenosine deaminase, RNA-specific 2.011
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 2.00115
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 2.00055

decreased expression

Symbol Name Standardized Value
TCTA T-cell leukemia translocation altered -10.0
HSPA1A heat shock 70kDa protein 1A -5.9741
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -5.2135
KDM3A lysine (K)-specific demethylase 3A -4.872
GRWD1 glutamate-rich WD repeat containing 1 -4.4796
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -3.4051
CORO1A coronin, actin binding protein, 1A -3.274
TSHB thyroid stimulating hormone, beta -3.2488
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -3.21793
CLCNKA chloride channel, voltage-sensitive Ka -3.0569
FOXRED2 FAD-dependent oxidoreductase domain containing 2 -3.0507
VILL villin-like -3.0457
PCDHGA5 protocadherin gamma subfamily A, 5 -3.0377
LOC107985101 uncharacterized LOC107985101 -3.033
IRGQ immunity-related GTPase family, Q -2.9978
TOM1 target of myb1 (chicken) -2.988
SPAG7 sperm associated antigen 7 -2.9671
CSH2 chorionic somatomammotropin hormone 2 -2.9554
EEIG1 estrogen-induced osteoclastogenesis regulator 1 -2.896
RPS5 ribosomal protein S5 -2.8492
CD5 CD5 molecule -2.7848
SPDEF SAM pointed domain containing ETS transcription factor -2.76403
PHACTR1 phosphatase and actin regulator 1 -2.7408
LZTR1 leucine-zipper-like transcription regulator 1 -2.7264
ARMC6 armadillo repeat containing 6 -2.7034
CLDN8 claudin 8 -2.6994
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain -2.6882
LY6G5C lymphocyte antigen 6 complex, locus G5C -2.6862
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 -2.6831
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae) -2.6257
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -2.62525
BCL2L2 BCL2-like 2 -2.6083
GREB1L growth regulation by estrogen in breast cancer-like -2.5561
TP53BP1 tumor protein p53 binding protein 1 -2.5488
GOLGA3 golgin A3 -2.524
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like -2.5209
GH1 growth hormone 1 -2.50818
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 -2.5011
CEP85 centrosomal protein 85kDa -2.4892
LOC122539214 Zinc finger protein LOC122539214 -2.4681
FSHB follicle stimulating hormone, beta polypeptide -2.4559
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1 -2.4478
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 -2.4328
TAOK3 TAO kinase 3 -2.4197
CSHL1 chorionic somatomammotropin hormone-like 1 -2.41563
MYL1 myosin, light chain 1, alkali; skeletal, fast -2.4034
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -2.4034
MRPS16 mitochondrial ribosomal protein S16 -2.3971
MVP major vault protein -2.3905
ACADVL acyl-CoA dehydrogenase, very long chain -2.3808
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -2.37735
SLC17A4 solute carrier family 17, member 4 -2.3706
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 -2.3675
ANGPTL4 angiopoietin-like 4 -2.3627
MNMIP1 manchette microtubule inner protein 1 -2.3596
LETMD1 LETM1 domain containing 1 -2.3402
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 -2.33925
ZNF747 zinc finger protein 747 -2.3374
RBM19 RNA binding motif protein 19 -2.33655
DUSP14 dual specificity phosphatase 14 -2.3336
HLA-A major histocompatibility complex, class I, A -2.3251
MYO9A myosin IXA -2.3157
ZNF26 zinc finger protein 26 -2.3009
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 -2.2755
ITPKC inositol-trisphosphate 3-kinase C -2.2668
KIF3B kinesin family member 3B -2.2633
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B -2.2599
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) -2.2596
CKM creatine kinase, muscle -2.2461
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2 -2.2435
HSDL2 hydroxysteroid dehydrogenase like 2 -2.23555
TPST2 tyrosylprotein sulfotransferase 2 -2.2342
BORCS8 BLOC-1 related complex subunit 8 -2.2322
CLCNKB chloride channel, voltage-sensitive Kb -2.1997
EBLN2 endogenous Bornavirus-like nucleoprotein 2 -2.1942
POLR2F polymerase (RNA) II (DNA directed) polypeptide F -2.193
TNK1 tyrosine kinase, non-receptor, 1 -2.1926
CD207 CD207 molecule, langerin -2.1869
MYH7B myosin, heavy chain 7B, cardiac muscle, beta -2.1833
ERC1 ELKS/RAB6-interacting/CAST family member 1 -2.1696
CCDC9 coiled-coil domain containing 9 -2.1662
KPTN kaptin (actin binding protein) -2.1654
LHX6 LIM homeobox 6 -2.1607
BSPRY B-box and SPRY domain containing -2.1581
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.1541
WDR4 WD repeat domain 4 -2.1417
GH2 growth hormone 2 -2.1414
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9 -2.14125
ACTA1 actin, alpha 1, skeletal muscle -2.136
DDTL D-dopachrome tautomerase-like -2.135
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -2.1313
ZNF324 zinc finger protein 324 -2.1283
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 -2.1234
GPA33 glycoprotein A33 (transmembrane) -2.1233
YIF1B Yip1 interacting factor homolog B (S. cerevisiae) -2.1105
PRKCQ protein kinase C, theta -2.11025
SUN2 Sad1 and UNC84 domain containing 2 -2.1014
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 -2.0999
SPTBN4 spectrin, beta, non-erythrocytic 4 -2.099
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 -2.0912
RDH5 retinol dehydrogenase 5 (11-cis/9-cis) -2.0909
BTNL8 butyrophilin-like 8 -2.0876
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 -2.087
CXCR1 chemokine (C-X-C motif) receptor 1 -2.0844
CCHCR1 coiled-coil alpha-helical rod protein 1 -2.08402
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) -2.0833
DYSF dysferlin -2.0797
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant -2.0782
SMIM5 small integral membrane protein 5 -2.0731
MAN1B1 mannosidase, alpha, class 1B, member 1 -2.05295
FLOT1 flotillin 1 -2.05197
PHC1 polyhomeotic homolog 1 (Drosophila) -2.0504
GUCA2A guanylate cyclase activator 2A (guanylin) -2.0493
SPATA2 spermatogenesis associated 2 -2.04045
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 -2.03825
IP6K2 inositol hexakisphosphate kinase 2 -2.0381
MYBPH myosin binding protein H -2.0201
FZD7 frizzled class receptor 7 -2.01955
TRPV6 transient receptor potential cation channel, subfamily V, member 6 -2.0192
ZCWPW1 zinc finger, CW type with PWWP domain 1 -2.0158
BCL2L13 BCL2-like 13 (apoptosis facilitator) -2.0152
HDAC5 histone deacetylase 5 -2.002