CRCGN015_MCF10A.TP53.M_24H:N22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phenylephrine 101.79 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

44 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:N22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CNRIP1 cannabinoid receptor interacting protein 1 5.0
TSEN2 TSEN2 tRNA splicing endonuclease subunit 4.9236
WFS1 Wolfram syndrome 1 (wolframin) 4.74295
RPL39L ribosomal protein L39-like 4.6625
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.4142
CHEK1 checkpoint kinase 1 4.02217
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 3.1246
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2.8866
RBKS ribokinase 2.88065
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.6767
IGHMBP2 immunoglobulin mu binding protein 2 2.61112
EIF5A2 eukaryotic translation initiation factor 5A2 2.45295
IREB2 iron-responsive element binding protein 2 2.32055
LYN LYN proto-oncogene, Src family tyrosine kinase 2.23043
CCDC85C coiled-coil domain containing 85C 2.22755
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.1808
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 2.1663
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 2.16335
GSTZ1 glutathione S-transferase zeta 1 2.16045
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 2.1474
KIF25 kinesin family member 25 2.07573
GPALPP1 GPALPP motifs containing 1 2.0708
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 2.05235
DSN1 DSN1, MIS12 kinetochore complex component 2.02765

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -5.842
ACOT9 acyl-CoA thioesterase 9 -5.07065
HMG20B high mobility group 20B -4.97657
TRAPPC3 trafficking protein particle complex 3 -4.5679
MRPS15 mitochondrial ribosomal protein S15 -4.1365
COTL1 coactosin-like F-actin binding protein 1 -3.1814
KRT14 keratin 14, type I -3.1273
GRN granulin -2.8428
SF3A3 splicing factor 3a, subunit 3, 60kDa -2.79735
HSPA1A heat shock 70kDa protein 1A -2.6495
TUBA4A tubulin, alpha 4a -2.52405
RPS5 ribosomal protein S5 -2.5042
NDUFS5 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) -2.4698
EEF2 eukaryotic translation elongation factor 2 -2.4195
TAC4 tachykinin 4 (hemokinin) -2.32635
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.27585
MAP7D1 MAP7 domain containing 1 -2.26025
AGO1 argonaute RISC catalytic component 1 -2.16855
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.08265
CBR3 carbonyl reductase 3 -2.07335