CRCGN015_MCF10A.TP53.M_24H:N23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phenylephrine 33.93 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

74 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:N23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCP110 centriolar coiled coil protein 110kDa 5.5052
SNAP25 synaptosomal-associated protein, 25kDa 4.7897
NUCB2 nucleobindin 2 4.62875
ZMIZ1 zinc finger, MIZ-type containing 1 4.01565
WIF1 WNT inhibitory factor 1 3.96185
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 3.43095
ADRB2 adrenoceptor beta 2, surface 3.39615
CNRIP1 cannabinoid receptor interacting protein 1 3.29995
CCNF cyclin F 3.26105
NOSIP nitric oxide synthase interacting protein 3.0399
LGMN legumain 2.80255
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.76805
MID1IP1 MID1 interacting protein 1 2.57105
PLS1 plastin 1 2.3307
DEPDC1 DEP domain containing 1 2.2802
PECR peroxisomal trans-2-enoyl-CoA reductase 2.25945
ACTN4 actinin, alpha 4 2.21395
MGST2 microsomal glutathione S-transferase 2 2.2018
HDAC7 histone deacetylase 7 2.17665
SMG5 SMG5 nonsense mediated mRNA decay factor 2.13325
PPA2 pyrophosphatase (inorganic) 2 2.12545
GNG12 guanine nucleotide binding protein (G protein), gamma 12 2.1234
TMEM38B transmembrane protein 38B 2.0904
NUP58 nucleoporin 58 2.08365
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.06445
SV2B synaptic vesicle glycoprotein 2B 2.0564
CHSY1 chondroitin sulfate synthase 1 2.05085
SPTSSA serine palmitoyltransferase, small subunit A 2.01795
BLTP3B bridge-like lipid transfer protein family member 3B 2.01655

decreased expression

Symbol Name Standardized Value
CCNB1 cyclin B1 -5.17885
MAPK13 mitogen-activated protein kinase 13 -4.67362
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.4969
COG7 component of oligomeric golgi complex 7 -4.46295
TRAPPC3 trafficking protein particle complex 3 -4.25798
SGK1 serum/glucocorticoid regulated kinase 1 -3.82305
EIF5 eukaryotic translation initiation factor 5 -3.44662
LMBR1L limb development membrane protein 1-like -3.3967
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -3.2468
LRRC41 leucine rich repeat containing 41 -2.98355
ACAA1 acetyl-CoA acyltransferase 1 -2.94907
MRPS15 mitochondrial ribosomal protein S15 -2.92975
TOR1A torsin family 1, member A (torsin A) -2.70115
FAM174B family with sequence similarity 174, member B -2.69405
PPP4C protein phosphatase 4, catalytic subunit -2.54675
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 -2.36845
PODNL1 podocan-like 1 -2.3288
CALHM2 calcium homeostasis modulator 2 -2.32845
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) -2.3091
COMMD9 COMM domain containing 9 -2.297
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 -2.2898
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 -2.25335
GZMM granzyme M (lymphocyte met-ase 1) -2.2074
RASL11B RAS-like, family 11, member B -2.2071
METTL22 methyltransferase like 22 -2.2059
CERT1 ceramide transporter 1 -2.17405
INTS14 integrator complex subunit 14 -2.15345
COL8A2 collagen, type VIII, alpha 2 -2.15265
TTYH1 tweety family member 1 -2.1385
TLE4 transducin-like enhancer of split 4 -2.13365
JMJD4 jumonji domain containing 4 -2.13145
WDR70 WD repeat domain 70 -2.13105
ACP2 acid phosphatase 2, lysosomal -2.13055
KCNK2 potassium channel, two pore domain subfamily K, member 2 -2.12675
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -2.12565
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 -2.08535
BSDC1 BSD domain containing 1 -2.0815
CNPY3-GNMT CNPY3-GNMT readthrough -2.059
DNALI1 dynein, axonemal, light intermediate chain 1 -2.05775
ZNF91 zinc finger protein 91 -2.04985
RAP1B RAP1B, member of RAS oncogene family -2.0394
LOC102724594 splicing factor U2AF 35 kDa subunit -2.02015
ZNF611 zinc finger protein 611 -2.0199
PTPRK protein tyrosine phosphatase, receptor type, K -2.01255
CD79B CD79b molecule, immunoglobulin-associated beta -2.00595