CRCGN015_MCF10A.TP53.M_24H:O01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

149 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:O01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STAP2 signal transducing adaptor family member 2 4.91295
IDE insulin-degrading enzyme 4.90691
AGR2 anterior gradient 2 4.75547
ADGRE5 adhesion G protein-coupled receptor E5 4.6739
CXCR4 chemokine (C-X-C motif) receptor 4 4.22864
KDM5D lysine (K)-specific demethylase 5D 4.22286
FGFR4 fibroblast growth factor receptor 4 4.16773
KLHL21 kelch-like family member 21 3.94163
AXIN1 axin 1 3.91079
STIMATE STIM activating enhancer 3.74942
MAP7 microtubule-associated protein 7 3.50239
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 3.42973
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 3.38344
TCTN1 tectonic family member 1 3.29074
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.97042
TLCD3A TLC domain containing 3A 2.89354
PALS1 protein associated with LIN7 1, MAGUK p55 family member 2.85001
PEX11A peroxisomal biogenesis factor 11 alpha 2.83482
TBC1D31 TBC1 domain family, member 31 2.78842
USP9Y ubiquitin specific peptidase 9, Y-linked 2.76887
HBB hemoglobin, beta 2.6894
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 2.67911
NLGN4Y neuroligin 4, Y-linked 2.63308
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.52816
BDH1 3-hydroxybutyrate dehydrogenase, type 1 2.48431
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 2.46546
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.43611
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) 2.361
RIPPLY2-CYB5R4 RIPPLY2-CYB5R4 readthrough 2.35615
RBM7 RNA binding motif protein 7 2.34309
TXNDC9 thioredoxin domain containing 9 2.32797
CSNK1A1 casein kinase 1, alpha 1 2.32052
UBE2K ubiquitin-conjugating enzyme E2K 2.28263
RPP30 ribonuclease P/MRP 30kDa subunit 2.24307
PRELID3B PRELI domain containing 3B 2.21418
SRFBP1 serum response factor binding protein 1 2.2029
TMEM38B transmembrane protein 38B 2.18313
GRPEL1 GrpE-like 1, mitochondrial (E. coli) 2.18269
WTAP Wilms tumor 1 associated protein 2.16928
TIAM1 T-cell lymphoma invasion and metastasis 1 2.16327
AK6 adenylate kinase 6 2.15135
CCDC6 coiled-coil domain containing 6 2.15105
HDAC2 histone deacetylase 2 2.1475
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 2.14283
LOC102724428 serine/threonine-protein kinase SIK1 2.13432
LDHC lactate dehydrogenase C 2.12147
TPD52L2 tumor protein D52-like 2 2.10887
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) 2.10532
CREB1 cAMP responsive element binding protein 1 2.07535
MAPK6 mitogen-activated protein kinase 6 2.07462
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 2.0711
CDK19 cyclin-dependent kinase 19 2.0645
MRPL42 mitochondrial ribosomal protein L42 2.05013
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.04518
WIF1 WNT inhibitory factor 1 2.03024
DCK deoxycytidine kinase 2.02853
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 2.01655
TTC1 tetratricopeptide repeat domain 1 2.01004

decreased expression

Symbol Name Standardized Value
COG7 component of oligomeric golgi complex 7 -5.99603
UFM1 ubiquitin-fold modifier 1 -4.49935
ACAA1 acetyl-CoA acyltransferase 1 -4.31491
OXA1L oxidase (cytochrome c) assembly 1-like -4.14862
RNF167 ring finger protein 167 -3.99287
C2CD5 C2 calcium-dependent domain containing 5 -3.94655
PSIP1 PC4 and SFRS1 interacting protein 1 -3.83293
MAGT1 magnesium transporter 1 -3.79546
KIF14 kinesin family member 14 -3.70867
MPHOSPH8 M-phase phosphoprotein 8 -3.51673
TRIM56 tripartite motif containing 56 -2.96534
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa -2.92643
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -2.92537
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -2.90752
ZNF611 zinc finger protein 611 -2.8665
DENND4C DENN/MADD domain containing 4C -2.8095
SMC1A structural maintenance of chromosomes 1A -2.79452
MTERF3 mitochondrial transcription termination factor 3 -2.63649
KDM5C lysine (K)-specific demethylase 5C -2.60272
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.59898
TKT transketolase -2.57849
CRYGD crystallin, gamma D -2.56859
PUDP pseudouridine 5'-phosphatase -2.54696
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 -2.54357
LMBR1L limb development membrane protein 1-like -2.5234
KRIT1 KRIT1, ankyrin repeat containing -2.48312
HMBOX1 homeobox containing 1 -2.48063
OFD1 oral-facial-digital syndrome 1 -2.47313
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 -2.46603
USP9X ubiquitin specific peptidase 9, X-linked -2.45469
RNF125 ring finger protein 125, E3 ubiquitin protein ligase -2.45307
RBBP6 retinoblastoma binding protein 6 -2.44278
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) -2.4102
BFAR bifunctional apoptosis regulator -2.40229
PRR11 proline rich 11 -2.3826
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) -2.37891
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 -2.37269
FLCN folliculin -2.35839
R3HDM2 R3H domain containing 2 -2.35645
NPIPB5 nuclear pore complex interacting protein family, member B5 -2.35535
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit -2.32961
HAUS2 HAUS augmin-like complex, subunit 2 -2.32376
BSDC1 BSD domain containing 1 -2.31241
EBLN2 endogenous Bornavirus-like nucleoprotein 2 -2.30529
PHACTR4 phosphatase and actin regulator 4 -2.29906
CLDN11 claudin 11 -2.29316
NPIPA6 nuclear pore complex interacting protein family, member A6 -2.28773
ATM ATM serine/threonine kinase -2.27682
WDR11 WD repeat domain 11 -2.266
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 -2.26582
SZT2 seizure threshold 2 homolog (mouse) -2.2619
DDTL D-dopachrome tautomerase-like -2.24854
UBA1 ubiquitin-like modifier activating enzyme 1 -2.24261
EP300 E1A binding protein p300 -2.22759
ALPK1 alpha-kinase 1 -2.22579
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) -2.22501
PODNL1 podocan-like 1 -2.22005
HNRNPCL1 heterogeneous nuclear ribonucleoprotein C-like 1 -2.16887
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 -2.1688
NPIPB4 nuclear pore complex interacting protein family, member B4 -2.16646
ZNF160 zinc finger protein 160 -2.14826
ZNF652 zinc finger protein 652 -2.14403
CAPN2 calpain 2, (m/II) large subunit -2.13366
GZMM granzyme M (lymphocyte met-ase 1) -2.13062
TMT1A thiol methyltransferase 1A -2.12825
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 -2.12213
WRN Werner syndrome, RecQ helicase-like -2.1163
ZNF669 zinc finger protein 669 -2.11047
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -2.10903
SYNPO2 synaptopodin 2 -2.10851
SIX1 SIX homeobox 1 -2.10385
VPS35L VPS35 endosomal protein sorting factor like -2.10001
ASB8 ankyrin repeat and SOCS box containing 8 -2.0976
ITGA9 integrin, alpha 9 -2.09288
CD248 CD248 molecule, endosialin -2.09049
DGKA diacylglycerol kinase, alpha 80kDa -2.07022
TASL TLR adaptor interacting with endolysosomal SLC15A4 -2.06585
BCKDK branched chain ketoacid dehydrogenase kinase -2.06548
CFDP1 craniofacial development protein 1 -2.05682
NPFFR1 neuropeptide FF receptor 1 -2.05429
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) -2.04857
HAGH hydroxyacylglutathione hydrolase -2.04202
SCRIB scribbled planar cell polarity protein -2.04095
MEGF8 multiple EGF-like-domains 8 -2.03209
COQ6 coenzyme Q6 monooxygenase -2.02228
CPT2 carnitine palmitoyltransferase 2 -2.02174
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 -2.01717
DOCK10 dedicator of cytokinesis 10 -2.01434
RFWD3 ring finger and WD repeat domain 3 -2.01074
ZNF276 zinc finger protein 276 -2.00467
MRPS31 mitochondrial ribosomal protein S31 -2.00302