CRCGN015_MCF10A.TP53.M_24H:O04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

74 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:O04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 4.16625
CARMIL1 capping protein regulator and myosin 1 linker 1 3.93507
KDM5D lysine (K)-specific demethylase 5D 3.90873
SPAG4 sperm associated antigen 4 3.84897
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 3.66772
CNRIP1 cannabinoid receptor interacting protein 1 3.59657
AXIN1 axin 1 3.38926
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 3.26452
WIF1 WNT inhibitory factor 1 2.85731
TSPAN6 tetraspanin 6 2.83776
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 2.73449
USP9Y ubiquitin specific peptidase 9, Y-linked 2.71278
NCAN neurocan 2.57756
ZNF587B zinc finger protein 587B 2.5566
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.53885
ZNF587 zinc finger protein 587 2.39456
HNRNPF heterogeneous nuclear ribonucleoprotein F 2.34429
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 2.33161
CDK7 cyclin-dependent kinase 7 2.32261
CDK20 cyclin-dependent kinase 20 2.22266
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 2.19368
RFX5 regulatory factor X, 5 (influences HLA class II expression) 2.19365
PARN poly(A)-specific ribonuclease 2.15953
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.15613
KRT6A keratin 6A, type II 2.12898
ZNF134 zinc finger protein 134 2.10245
ADCY7 adenylate cyclase 7 2.08112
EVL Enah/Vasp-like 2.06262
ZFY zinc finger protein, Y-linked 2.04724
RHCG Rh family, C glycoprotein 2.02791
CCL2 chemokine (C-C motif) ligand 2 2.02701
CRNN cornulin 2.0253
DHRS7B dehydrogenase/reductase (SDR family) member 7B 2.01338

decreased expression

Symbol Name Standardized Value
IFRD2 interferon-related developmental regulator 2 -4.88746
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -4.19353
C2CD5 C2 calcium-dependent domain containing 5 -3.9164
TMEM115 transmembrane protein 115 -3.7941
KIF20A kinesin family member 20A -3.70186
APEH acylaminoacyl-peptide hydrolase -3.59274
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -3.36453
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -3.36184
TUSC2 tumor suppressor candidate 2 -3.27236
HSPA1A heat shock 70kDa protein 1A -3.19756
COTL1 coactosin-like F-actin binding protein 1 -3.19152
KDM5C lysine (K)-specific demethylase 5C -3.10029
CYB561D2 cytochrome b561 family, member D2 -2.8597
CYCS cytochrome c, somatic -2.63232
ACY1 aminoacylase 1 -2.60046
INTS11 integrator complex subunit 11 -2.59771
VILL villin-like -2.49746
ANTKMT adenine nucleotide translocase lysine methyltransferase -2.48964
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.48673
CAPN15 calpain 15 -2.45456
NCLN nicalin -2.44904
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -2.4162
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast) -2.3965
ABHD14A abhydrolase domain containing 14A -2.3528
MPC2 mitochondrial pyruvate carrier 2 -2.32815
ACAA1 acetyl-CoA acyltransferase 1 -2.30866
CD44 CD44 molecule (Indian blood group) -2.25639
GMIP GEM interacting protein -2.19781
SFMBT1 Scm-like with four mbt domains 1 -2.1611
MARCHF3 membrane associated ring-CH-type finger 3 -2.15729
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites -2.10077
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 -2.08479
JMJD4 jumonji domain containing 4 -2.08172
TFF2 trefoil factor 2 -2.0814
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B -2.07309
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 -2.06299
GARS1 glycyl-tRNA synthetase 1 -2.04354
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like -2.01945
MATK megakaryocyte-associated tyrosine kinase -2.01694
TSR3 TSR3, 20S rRNA accumulation, homolog (S. cerevisiae) -2.01605
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.00623