CRCGN015_MCF10A.TP53.M_24H:O06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

81 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:O06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 5.42545
TLR4 toll-like receptor 4 4.9198
VGLL4 vestigial-like family member 4 3.48145
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 3.38915
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 3.28323
BMP4 bone morphogenetic protein 4 3.2017
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.9124
PHC2 polyhomeotic homolog 2 (Drosophila) 2.89385
GARRE1 granule associated Rac and RHOG effector 1 2.81045
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant 2.71575
UBE2D1 ubiquitin-conjugating enzyme E2D 1 2.59452
HBB hemoglobin, beta 2.58377
C5AR1 complement component 5a receptor 1 2.56615
ATG7 autophagy related 7 2.53905
CHN1 chimerin 1 2.4807
CLEC7A C-type lectin domain family 7, member A 2.4296
MMP1 matrix metallopeptidase 1 2.4005
WIF1 WNT inhibitory factor 1 2.4001
BRIX1 BRX1, biogenesis of ribosomes 2.3437
CLEC4A C-type lectin domain family 4, member A 2.2888
AOAH acyloxyacyl hydrolase (neutrophil) 2.2325
YIPF5 Yip1 domain family, member 5 2.21665
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.20618
TUT7 terminal uridylyl transferase 7 2.17745
FPR2 formyl peptide receptor 2 2.15195
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 2.1364
GFRA1 GDNF family receptor alpha 1 2.11835
HIGD1B HIG1 hypoxia inducible domain family, member 1B 2.11375
MARCHF1 membrane associated ring-CH-type finger 1 2.1117
MRPL17 mitochondrial ribosomal protein L17 2.11165
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 2.1082
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 2.1076
HACD3 3-hydroxyacyl-CoA dehydratase 3 2.10465
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 2.0974
COPS7A COP9 signalosome subunit 7A 2.09535
S100A2 S100 calcium binding protein A2 2.08265
TLR8 toll-like receptor 8 2.07845
PRR7 proline rich 7 (synaptic) 2.0664
EVI2B ecotropic viral integration site 2B 2.05685
PTPRJ protein tyrosine phosphatase, receptor type, J 2.023
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 2.0225
LAPTM4A lysosomal protein transmembrane 4 alpha 2.0214
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 2.01553

decreased expression

Symbol Name Standardized Value
DNM1L dynamin 1-like -4.8225
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -4.62385
PUF60 poly-U binding splicing factor 60KDa -4.5311
CDK2 cyclin-dependent kinase 2 -4.46237
SCYL3 SCY1-like 3 (S. cerevisiae) -4.36697
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.0655
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.76283
SNCA synuclein, alpha (non A4 component of amyloid precursor) -3.3724
KIFAP3 kinesin-associated protein 3 -2.63655
ZNF7 zinc finger protein 7 -2.6353
C1QBP complement component 1, q subcomponent binding protein -2.54872
CAPN3 calpain 3, (p94) -2.4752
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.47035
QPRT quinolinate phosphoribosyltransferase -2.4169
SCRIB scribbled planar cell polarity protein -2.4141
TYR tyrosinase -2.39745
NISCH nischarin -2.39205
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.37095
RSRC2 arginine/serine-rich coiled-coil 2 -2.36667
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1 -2.3195
MLANA melan-A -2.30962
GPR143 G protein-coupled receptor 143 -2.25265
POLG2 polymerase (DNA directed), gamma 2, accessory subunit -2.24085
WDR12 WD repeat domain 12 -2.2192
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) -2.20555
CTC1 CTS telomere maintenance complex component 1 -2.1132
SLC45A2 solute carrier family 45, member 2 -2.09763
SMYD3 SET and MYND domain containing 3 -2.09655
CAPRIN2 caprin family member 2 -2.0937
WASHC3 WASH complex subunit 3 -2.09075
HMBOX1 homeobox containing 1 -2.0626
WDR47 WD repeat domain 47 -2.0547
R3HDM2 R3H domain containing 2 -2.0417
NDE1 nudE neurodevelopment protein 1 -2.0168
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.01255
TENM4 teneurin transmembrane protein 4 -2.01185
WDR26 WD repeat domain 26 -2.00545
OCA2 oculocutaneous albinism II -2.00305