CRCGN015_MCF10A.TP53.M_24H:O13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description catechol 98.9 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

90 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:O13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 4.10115
TSPAN6 tetraspanin 6 4.08335
CDCA4 cell division cycle associated 4 3.86145
COMP cartilage oligomeric matrix protein 3.74715
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 3.39065
GPATCH8 G patch domain containing 8 3.28352
CAPN1 calpain 1, (mu/I) large subunit 2.7783
PECR peroxisomal trans-2-enoyl-CoA reductase 2.49205
SOWAHC sosondowah ankyrin repeat domain family member C 2.3606
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 2.35435
USP39 ubiquitin specific peptidase 39 2.3272
HDAC5 histone deacetylase 5 2.32045
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 2.27985
PEF1 penta-EF-hand domain containing 1 2.22085
LIMS2 LIM and senescent cell antigen-like domains 2 2.21275
TSKU tsukushi, small leucine rich proteoglycan 2.19425
INPP5A inositol polyphosphate-5-phosphatase, 40kDa 2.1842
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 2.1787
YARS1 tyrosyl-tRNA synthetase 1 2.17765
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 2.14045
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 2.12705
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.1142
MFAP2 microfibrillar-associated protein 2 2.1087
MAP3K14 mitogen-activated protein kinase kinase kinase 14 2.10025
ARFGAP2 ADP-ribosylation factor GTPase activating protein 2 2.0822
LITAF lipopolysaccharide-induced TNF factor 2.0785
SFTPD surfactant protein D 2.07405
VAMP8 vesicle-associated membrane protein 8 2.05185
H2AC19 H2A clustered histone 19 2.04747
C4BPA complement component 4 binding protein, alpha 2.0361
CLDN4 claudin 4 2.0218
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) 2.0198
VRK2 vaccinia related kinase 2 2.00655

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -5.0
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -4.71753
HMG20B high mobility group 20B -4.6458
LDHD lactate dehydrogenase D -4.587
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.4105
CCDC86 coiled-coil domain containing 86 -4.13935
FPGS folylpolyglutamate synthase -3.87035
C1QBP complement component 1, q subcomponent binding protein -3.54677
SGK1 serum/glucocorticoid regulated kinase 1 -3.5187
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -3.23427
COG5 component of oligomeric golgi complex 5 -3.06865
SRPK2 SRSF protein kinase 2 -2.99053
KRT14 keratin 14, type I -2.97585
MTERF3 mitochondrial transcription termination factor 3 -2.9268
DDRGK1 DDRGK domain containing 1 -2.87275
CORO1A coronin, actin binding protein, 1A -2.83025
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -2.82565
PANK2 pantothenate kinase 2 -2.76125
TKTL1 transketolase-like 1 -2.75835
PUS7 pseudouridylate synthase 7 (putative) -2.67745
DUS4L dihydrouridine synthase 4-like (S. cerevisiae) -2.63473
KDM3A lysine (K)-specific demethylase 3A -2.5957
CRNKL1 crooked neck pre-mRNA splicing factor 1 -2.54735
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 -2.51155
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A -2.48355
UNG uracil-DNA glycosylase -2.48185
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -2.47025
TMEM230 transmembrane protein 230 -2.46685
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.3953
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa -2.36035
MKKS McKusick-Kaufman syndrome -2.32135
MFSD12 major facilitator superfamily domain containing 12 -2.23878
DTD1 D-tyrosyl-tRNA deacylase 1 -2.22355
LOC102723713 TP53-target gene 3 protein -2.2213
BTBD1 BTB (POZ) domain containing 1 -2.2085
RBM28 RNA binding motif protein 28 -2.2048
HSPD1 heat shock 60kDa protein 1 (chaperonin) -2.19403
FHOD1 formin homology 2 domain containing 1 -2.1807
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -2.1696
MAVS mitochondrial antiviral signaling protein -2.15675
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -2.15385
MRGBP MRG/MORF4L binding protein -2.13105
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) -2.12275
CSE1L CSE1 chromosome segregation 1-like (yeast) -2.12047
TYMS thymidylate synthetase -2.12045
CSAG2 CSAG family, member 2 -2.10205
NSFL1C NSFL1 (p97) cofactor (p47) -2.07512
SLC7A10 solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10 -2.0739
FKBP1C FK506 binding protein 1C -2.06527
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase -2.01585
C2CD5 C2 calcium-dependent domain containing 5 -2.0154
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -2.0144
MAN1A1 mannosidase, alpha, class 1A, member 1 -2.01358
MAPK8 mitogen-activated protein kinase 8 -2.0133
SEC23B Sec23 homolog B (S. cerevisiae) -2.01313
LOC100533997 MAGEA10-MAGEA5 readthrough -2.0123
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.01085