CRCGN015_MCF10A.TP53.M_24H:O14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description catechol 32.97 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

119 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:O14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TOPBP1 topoisomerase (DNA) II binding protein 1 5.95575
CXCR4 chemokine (C-X-C motif) receptor 4 5.12837
RPL39L ribosomal protein L39-like 4.91845
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 4.91665
CHEK1 checkpoint kinase 1 4.9084
RAB21 RAB21, member RAS oncogene family 4.83695
DNM1 dynamin 1 4.1402
ACAA1 acetyl-CoA acyltransferase 1 3.72992
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 3.52965
DENND2D DENN/MADD domain containing 2D 3.3252
FZD1 frizzled class receptor 1 2.94798
PDLIM1 PDZ and LIM domain 1 2.8604
WASHC5 WASH complex subunit 5 2.7893
TCTN1 tectonic family member 1 2.7409
FCHO1 FCH domain only 1 2.7224
CRELD2 cysteine-rich with EGF-like domains 2 2.5697
CCNA1 cyclin A1 2.5504
MMP2 matrix metallopeptidase 2 2.51325
SMIM40 small integral membrane protein 40 2.4901
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 2.4587
CHKB choline kinase beta 2.45175
FANCF Fanconi anemia, complementation group F 2.4201
DSCC1 DNA replication and sister chromatid cohesion 1 2.40335
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor 2.3892
HTRA1 HtrA serine peptidase 1 2.38125
METTL16 methyltransferase like 16 2.32715
CENPI centromere protein I 2.3228
ATAD2 ATPase family, AAA domain containing 2 2.28155
HAUS6 HAUS augmin-like complex, subunit 6 2.27795
WDHD1 WD repeat and HMG-box DNA binding protein 1 2.27435
LY6H lymphocyte antigen 6 complex, locus H 2.24365
NCS1 neuronal calcium sensor 1 2.24305
CORO1A coronin, actin binding protein, 1A 2.22805
ARHGAP11A Rho GTPase activating protein 11A 2.22765
KLK10 kallikrein-related peptidase 10 2.22665
R3HCC1L R3H domain and coiled-coil containing 1-like 2.2232
METTL2A methyltransferase like 2A 2.21207
TIMP2 TIMP metallopeptidase inhibitor 2 2.1983
IREB2 iron-responsive element binding protein 2 2.19485
PARPBP PARP1 binding protein 2.18165
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 2.1773
OSBPL10 oxysterol binding protein-like 10 2.17545
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 2.17395
SIX6 SIX homeobox 6 2.17345
CTRL chymotrypsin-like 2.1587
LRRC37A3 leucine rich repeat containing 37, member A3 2.1572
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 2.1538
WDR76 WD repeat domain 76 2.15365
ND5 NADH dehydrogenase subunit 5 2.15105
SIX3 SIX homeobox 3 2.14205
ARHGAP8 Rho GTPase activating protein 8 2.13775
MMP13 matrix metallopeptidase 13 2.13165
S100A5 S100 calcium binding protein A5 2.1228
ABHD11 abhydrolase domain containing 11 2.1195
IFNAR1 interferon (alpha, beta and omega) receptor 1 2.11605
PRIM2 primase, DNA, polypeptide 2 (58kDa) 2.10842
CDK3 cyclin-dependent kinase 3 2.1039
IGFBP3 insulin-like growth factor binding protein 3 2.09705
CALY calcyon neuron-specific vesicular protein 2.08715
POLR1F RNA polymerase I subunit F 2.0855
CENPQ centromere protein Q 2.0804
ZNF334 zinc finger protein 334 2.0765
ARSJ arylsulfatase family, member J 2.073
FAAP100 FA core complex associated protein 100 2.0713
ZNF273 zinc finger protein 273 2.0658
EIF5A2 eukaryotic translation initiation factor 5A2 2.06365
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 2.06
ZNF107 zinc finger protein 107 2.0577
FSHB follicle stimulating hormone, beta polypeptide 2.0575
SERHL2 serine hydrolase-like 2 2.05585
STX4 syntaxin 4 2.05485
ZNF669 zinc finger protein 669 2.05095
MATN3 matrilin 3 2.048
ARL4C ADP-ribosylation factor-like 4C 2.04677
HYOU1 hypoxia up-regulated 1 2.02915
FIRRM FIGNL1 interacting regulator of recombination and mitosis 2.027
PEG10 paternally expressed 10 2.02647
CAPN1 calpain 1, (mu/I) large subunit 2.0218
TRAPPC6A trafficking protein particle complex 6A 2.02145
H2BC21 H2B clustered histone 21 2.01915
KCNK12 potassium channel, two pore domain subfamily K, member 12 2.01785
PSPH phosphoserine phosphatase 2.01562
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 2.01117
KIF18A kinesin family member 18A 2.0054
IL26 interleukin 26 2.00325
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.00295
DYNLT3 dynein, light chain, Tctex-type 3 2.0004

decreased expression

Symbol Name Standardized Value
DHRS7 dehydrogenase/reductase (SDR family) member 7 -5.722
BAG3 BCL2-associated athanogene 3 -5.40885
PCNA proliferating cell nuclear antigen -5.33015
TEX10 testis expressed 10 -5.1748
ADI1 acireductone dioxygenase 1 -5.0025
PRCP prolylcarboxypeptidase (angiotensinase C) -4.22115
THAP11 THAP domain containing 11 -2.99135
REXO2 RNA exonuclease 2 -2.96326
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -2.94705
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.65373
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.63503
MGST2 microsomal glutathione S-transferase 2 -2.57775
TMEM230 transmembrane protein 230 -2.50565
CAB39 calcium binding protein 39 -2.4637
FOXO4 forkhead box O4 -2.32825
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.3235
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 -2.31305
S100P S100 calcium binding protein P -2.3025
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -2.2735
FAM53C family with sequence similarity 53, member C -2.2539
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.23948
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) -2.15475
CD320 CD320 molecule -2.15405
CD81 CD81 molecule -2.1464
EIF4A3 eukaryotic translation initiation factor 4A3 -2.12945
KRT14 keratin 14, type I -2.10915
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.06405
TMEM59 transmembrane protein 59 -2.05775
RBBP7 retinoblastoma binding protein 7 -2.0479
EP400 E1A binding protein p400 -2.03048
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) -2.0222
TIMP1 TIMP metallopeptidase inhibitor 1 -2.0139