CRCGN015_MCF10A.TP53.M_24H:O16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 5-nitroacenaphthene 98.4 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

130 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:O16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PNKP polynucleotide kinase 3'-phosphatase 5.7835
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 5.3828
SNAP25 synaptosomal-associated protein, 25kDa 5.21905
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.67345
KDM5A lysine (K)-specific demethylase 5A 4.5394
GPER1 G protein-coupled estrogen receptor 1 4.46285
WIF1 WNT inhibitory factor 1 4.33615
PHGDH phosphoglycerate dehydrogenase 3.81307
DENND2D DENN/MADD domain containing 2D 3.6212
PYCR1 pyrroline-5-carboxylate reductase 1 3.5344
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.5083
SYT1 synaptotagmin I 3.50542
STMN2 stathmin 2 3.44487
AARS1 alanyl-tRNA synthetase 1 3.39755
NSG2 neuronal vesicle trafficking associated 2 3.2315
GSTZ1 glutathione S-transferase zeta 1 3.16395
GARRE1 granule associated Rac and RHOG effector 1 3.13055
ISG15 ISG15 ubiquitin-like modifier 3.12425
SNAP91 synaptosomal-associated protein, 91kDa 3.0563
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.90845
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.83525
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.77095
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.7594
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2.70995
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.6879
LYRM1 LYR motif containing 1 2.63655
CARTPT CART prepropeptide 2.6155
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 2.60512
PCCB propionyl CoA carboxylase, beta polypeptide 2.5786
MX1 MX dynamin-like GTPase 1 2.56645
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 2.53045
CHGB chromogranin B 2.52695
STAMBP STAM binding protein 2.52465
ELP3 elongator acetyltransferase complex subunit 3 2.49365
NEFM neurofilament, medium polypeptide 2.4273
LGI1 leucine-rich, glioma inactivated 1 2.4186
ADIPOR2 adiponectin receptor 2 2.4184
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.4075
MOAP1 modulator of apoptosis 1 2.39165
ADAR adenosine deaminase, RNA-specific 2.38985
INTS3 integrator complex subunit 3 2.36935
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.3448
PENK proenkephalin 2.3295
VSNL1 visinin-like 1 2.32397
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.3186
IARS1 isoleucyl-tRNA synthetase 1 2.31355
NPY neuropeptide Y 2.3019
MRPS16 mitochondrial ribosomal protein S16 2.2971
ENDOD1 endonuclease domain containing 1 2.2772
EPRS1 glutamyl-prolyl-tRNA synthetase 1 2.25368
GSK3B glycogen synthase kinase 3 beta 2.24815
LRRN3 leucine rich repeat neuronal 3 2.22185
ETNPPL ethanolamine-phosphate phospho-lyase 2.19155
OASL 2'-5'-oligoadenylate synthetase-like 2.18458
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.1779
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 2.15105
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 2.14453
RUNDC3A RUN domain containing 3A 2.14328
SLC26A3 solute carrier family 26 (anion exchanger), member 3 2.11825
RUNDC3B RUN domain containing 3B 2.11475
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.1069
TCERG1 transcription elongation regulator 1 2.10615
UQCRC2 ubiquinol-cytochrome c reductase core protein II 2.09973
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 2.0842
ATMIN ATM interactor 2.07842
TMBIM6 transmembrane BAX inhibitor motif containing 6 2.07735
PSAT1 phosphoserine aminotransferase 1 2.0754
ZFAND3 zinc finger, AN1-type domain 3 2.07065
CMTR1 cap methyltransferase 1 2.06335
YARS1 tyrosyl-tRNA synthetase 1 2.0604
NELL1 NEL-like 1 (chicken) 2.0596
PGR progesterone receptor 2.05725
SCG2 secretogranin II 2.0512
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.03565
ASTN1 astrotactin 1 2.0123
IFI44L interferon-induced protein 44-like 2.0041
TRAPPC2L trafficking protein particle complex 2-like 2.00215

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -5.43328
TUBB6 tubulin, beta 6 class V -5.39835
SLC25A46 solute carrier family 25, member 46 -5.0597
SGK1 serum/glucocorticoid regulated kinase 1 -4.836
PCNA proliferating cell nuclear antigen -4.66275
PSRC1 proline/serine-rich coiled-coil 1 -3.581
CBR3 carbonyl reductase 3 -3.2774
CD320 CD320 molecule -3.27115
MSMO1 methylsterol monooxygenase 1 -3.10065
ACAA1 acetyl-CoA acyltransferase 1 -3.01795
INSIG1 insulin induced gene 1 -2.86212
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.8538
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.8152
NT5DC2 5'-nucleotidase domain containing 2 -2.68335
MSN moesin -2.67535
HSPA1A heat shock 70kDa protein 1A -2.6678
ELOVL6 ELOVL fatty acid elongase 6 -2.65107
DHCR24 24-dehydrocholesterol reductase -2.62295
ADIPOQ adiponectin, C1Q and collagen domain containing -2.5912
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.49165
PITX1 paired-like homeodomain 1 -2.46683
SH3BP4 SH3-domain binding protein 4 -2.46585
PHLDA3 pleckstrin homology-like domain, family A, member 3 -2.4487
RNASE4 ribonuclease, RNase A family, 4 -2.43563
PANK2 pantothenate kinase 2 -2.4121
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon -2.4061
PFN1 profilin 1 -2.3647
S100A4 S100 calcium binding protein A4 -2.3596
TPSAB1 tryptase alpha/beta 1 -2.30313
ACO1 aconitase 1, soluble -2.2804
RIPK4 receptor-interacting serine-threonine kinase 4 -2.2739
KRT4 keratin 4, type II -2.2685
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -2.2459
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.24472
DCT dopachrome tautomerase -2.2309
PLIN1 perilipin 1 -2.21225
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 -2.2106
NR2F1 nuclear receptor subfamily 2, group F, member 1 -2.20778
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.18475
COTL1 coactosin-like F-actin binding protein 1 -2.17335
MITF microphthalmia-associated transcription factor -2.15395
RRP1B ribosomal RNA processing 1B -2.1415
MRPL4 mitochondrial ribosomal protein L4 -2.1261
HCAR3 hydroxycarboxylic acid receptor 3 -2.07515
DTX2 deltex 2, E3 ubiquitin ligase -2.07495
BASP1 brain abundant, membrane attached signal protein 1 -2.0619
MAVS mitochondrial antiviral signaling protein -2.0388
SLC39A1 solute carrier family 39 (zinc transporter), member 1 -2.02725
ETV4 ets variant 4 -2.02415
CIDEC cell death-inducing DFFA-like effector c -2.01965
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) -2.01817
TUBB4B tubulin, beta 4B class IVb -2.01627
ANG angiogenin, ribonuclease, RNase A family, 5 -2.0131