CRCGN015_MCF10A.TP53.M_24H:O17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 5-nitroacenaphthene 32.8 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

88 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:O17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 5.0
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.92075
ZNF134 zinc finger protein 134 4.14845
KDM5D lysine (K)-specific demethylase 5D 4.064
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 3.83807
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 3.76213
ACAA1 acetyl-CoA acyltransferase 1 3.66177
ZNF587B zinc finger protein 587B 3.2172
ZFY zinc finger protein, Y-linked 3.18295
USP9Y ubiquitin specific peptidase 9, Y-linked 3.17405
ZNF419 zinc finger protein 419 3.08313
NRIP3 nuclear receptor interacting protein 3 2.7787
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.7676
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 2.68088
ZNF551 zinc finger protein 551 2.653
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 2.54885
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.5472
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.4972
ZNF268 zinc finger protein 268 2.44
NAT10 N-acetyltransferase 10 (GCN5-related) 2.4299
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 2.42895
ACLY ATP citrate lyase 2.41668
ZNF222 zinc finger protein 222 2.39345
BCL3 B-cell CLL/lymphoma 3 2.35003
ZNF544 zinc finger protein 544 2.33825
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 2.33595
WDR43 WD repeat domain 43 2.2956
CCDC85B coiled-coil domain containing 85B 2.2861
AQP4 aquaporin 4 2.27129
EXOSC5 exosome component 5 2.2642
ARSJ arylsulfatase family, member J 2.2496
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa 2.2367
ZNF304 zinc finger protein 304 2.21725
ZNF154 zinc finger protein 154 2.1811
ZNF671 zinc finger protein 671 2.13425
TRAPPC6A trafficking protein particle complex 6A 2.133
ZNF22 zinc finger protein 22 2.12993
UBE2M ubiquitin-conjugating enzyme E2M 2.12465
GAS2L1 growth arrest-specific 2 like 1 2.11037
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.11015
R3HDM4 R3H domain containing 4 2.10978
RBMY1J RNA binding motif protein, Y-linked, family 1, member J 2.0949
TBC1D17 TBC1 domain family, member 17 2.09345
HOXB13 homeobox B13 2.0897
TTC27 tetratricopeptide repeat domain 27 2.08885
UBAC1 UBA domain containing 1 2.07825
MYBPC1 myosin binding protein C, slow type 2.0756
SPIB Spi-B transcription factor (Spi-1/PU.1 related) 2.07115
UBA6 ubiquitin-like modifier activating enzyme 6 2.0669
FASTKD2 FAST kinase domains 2 2.05233
ZNF211 zinc finger protein 211 2.04225
ZNF548 zinc finger protein 548 2.0365
CARM1 coactivator-associated arginine methyltransferase 1 2.03475
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 2.0324
ETNPPL ethanolamine-phosphate phospho-lyase 2.0221
FBXO46 F-box protein 46 2.02035
ZNF350 zinc finger protein 350 2.00445
ZNF587 zinc finger protein 587 2.0007

decreased expression

Symbol Name Standardized Value
HSPA1A heat shock 70kDa protein 1A -6.29895
TSPAN4 tetraspanin 4 -5.75632
ITFG1 integrin alpha FG-GAP repeat containing 1 -5.2236
PCNA proliferating cell nuclear antigen -5.0
NRIP1 nuclear receptor interacting protein 1 -3.85435
CLTB clathrin, light chain B -3.83671
COTL1 coactosin-like F-actin binding protein 1 -3.8183
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.61495
SMC1A structural maintenance of chromosomes 1A -3.3373
ANKRD10 ankyrin repeat domain 10 -3.294
TUBA4A tubulin, alpha 4a -2.92195
CSK c-src tyrosine kinase -2.78935
UBA1 ubiquitin-like modifier activating enzyme 1 -2.76255
DDRGK1 DDRGK domain containing 1 -2.5787
KDM6A lysine (K)-specific demethylase 6A -2.56455
CD320 CD320 molecule -2.5582
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.5344
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) -2.512
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -2.4871
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -2.36145
HSPA1B heat shock 70kDa protein 1B -2.33002
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.28208
GPX3 glutathione peroxidase 3 -2.23167
KDM5C lysine (K)-specific demethylase 5C -2.2277
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 -2.2032
TMEM131 transmembrane protein 131 -2.1582
CDKN2AIP CDKN2A interacting protein -2.09725
PANK2 pantothenate kinase 2 -2.07645
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.06002
TMEM230 transmembrane protein 230 -2.0049