CRCGN015_MCF10A.TP53.M_24H:O18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 5-nitroacenaphthene 10.93 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

184 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:O18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 5.81882
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 5.37378
C2CD2 C2 calcium-dependent domain containing 2 5.15455
KDM5D lysine (K)-specific demethylase 5D 4.87845
CDCA4 cell division cycle associated 4 4.63565
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 4.57937
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.41207
SYNE2 spectrin repeat containing, nuclear envelope 2 4.3749
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 4.3329
HLA-DRA major histocompatibility complex, class II, DR alpha 4.12533
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 4.10625
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 3.85472
CCL2 chemokine (C-C motif) ligand 2 3.8477
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 3.80495
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 3.767
MTA2 metastasis associated 1 family, member 2 3.666
USP9Y ubiquitin specific peptidase 9, Y-linked 3.59825
NSDHL NAD(P) dependent steroid dehydrogenase-like 3.59483
PRR7 proline rich 7 (synaptic) 3.52165
ACAA1 acetyl-CoA acyltransferase 1 3.42947
HBA1 hemoglobin, alpha 1 3.34392
HYOU1 hypoxia up-regulated 1 3.28505
RBBP5 retinoblastoma binding protein 5 3.2702
DENND1C DENN/MADD domain containing 1C 3.191
CGRRF1 cell growth regulator with ring finger domain 1 3.1592
CNRIP1 cannabinoid receptor interacting protein 1 2.95395
MDM4 MDM4, p53 regulator 2.93345
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 2.9222
ARF6 ADP-ribosylation factor 6 2.85707
FAM193B family with sequence similarity 193, member B 2.6158
THRAP3 thyroid hormone receptor associated protein 3 2.59405
CA5A carbonic anhydrase VA, mitochondrial 2.57685
CETN2 centrin, EF-hand protein, 2 2.5763
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 2.56833
PTPN14 protein tyrosine phosphatase, non-receptor type 14 2.55215
CRNN cornulin 2.5514
ACKR5 atypical chemokine receptor 5 2.5338
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 2.51172
GOLGA8F golgin A8 family, member F 2.49905
PRPF39 pre-mRNA processing factor 39 2.4911
GINS4 GINS complex subunit 4 (Sld5 homolog) 2.48245
CD5L CD5 molecule-like 2.4813
RBMX2 RNA binding motif protein, X-linked 2 2.48
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.4696
AGK acylglycerol kinase 2.46015
ORC6 origin recognition complex, subunit 6 2.45825
DOCK5 dedicator of cytokinesis 5 2.43735
DDN dendrin 2.4294
DCHS2 dachsous cadherin-related 2 2.4122
STAB2 stabilin 2 2.396
SH2B2 SH2B adaptor protein 2 2.3895
GPR19 G protein-coupled receptor 19 2.37
PRR15L proline rich 15-like 2.34155
NRIP3 nuclear receptor interacting protein 3 2.32445
TJP1 tight junction protein 1 2.31198
NCK1 NCK adaptor protein 1 2.3107
GDF2 growth differentiation factor 2 2.30855
COMMD8 COMM domain containing 8 2.2945
ANGPTL7 angiopoietin-like 7 2.29385
GJB4 gap junction protein, beta 4, 30.3kDa 2.2886
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 2.27855
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 2.2767
KRT13 keratin 13, type I 2.27605
ALAS1 5'-aminolevulinate synthase 1 2.2743
SNCAIP synuclein, alpha interacting protein 2.2724
EMP1 epithelial membrane protein 1 2.2701
LTBP1 latent transforming growth factor beta binding protein 1 2.26822
BAHCC1 BAH domain and coiled-coil containing 1 2.26485
CRHBP corticotropin releasing hormone binding protein 2.2647
TMEM164 transmembrane protein 164 2.25725
TAS2R4 taste receptor, type 2, member 4 2.25305
MYOZ1 myozenin 1 2.2265
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A 2.2238
GYPC glycophorin C (Gerbich blood group) 2.21275
ZNF669 zinc finger protein 669 2.19385
LHX6 LIM homeobox 6 2.1715
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) 2.16915
ZNF652 zinc finger protein 652 2.1584
PDE2A phosphodiesterase 2A, cGMP-stimulated 2.14805
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 2.1475
RAMP3 receptor (G protein-coupled) activity modifying protein 3 2.1332
SFT2D2 SFT2 domain containing 2 2.12295
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 2.12085
FGF17 fibroblast growth factor 17 2.11825
TCAP titin-cap 2.11655
SPINK5 serine peptidase inhibitor, Kazal type 5 2.11325
CEP85 centrosomal protein 85kDa 2.1115
CCNT1 cyclin T1 2.11095
ZFY zinc finger protein, Y-linked 2.10285
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.10195
CHST10 carbohydrate sulfotransferase 10 2.1014
CLEC1A C-type lectin domain family 1, member A 2.09995
KRT38 keratin 38, type I 2.0945
CD48 CD48 molecule 2.08985
HGH1 HGH1 homolog (S. cerevisiae) 2.08877
HDAC2 histone deacetylase 2 2.0818
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 2.079
MYOM2 myomesin 2 2.0695
WDR73 WD repeat domain 73 2.06725
CCL14 chemokine (C-C motif) ligand 14 2.05385
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) 2.05385
ASB7 ankyrin repeat and SOCS box containing 7 2.0513
SLC25A40 solute carrier family 25, member 40 2.0493
HYDIN HYDIN, axonemal central pair apparatus protein 2.0488
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.04455
HSBP1 heat shock factor binding protein 1 2.04282
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) 2.041
SLC45A2 solute carrier family 45, member 2 2.03632
IFNA13 interferon, alpha 13 2.0354
PXMP4 peroxisomal membrane protein 4, 24kDa 2.0344
CWF19L1 CWF19-like 1, cell cycle control (S. pombe) 2.0297
DND1 DND microRNA-mediated repression inhibitor 1 2.01682
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 2.0147
ITGA9 integrin, alpha 9 2.0051
FDX1 ferredoxin 1 2.00413
TACO1 translational activator of mitochondrially encoded cytochrome c oxidase I 2.00235

decreased expression

Symbol Name Standardized Value
DIPK1A divergent protein kinase domain 1A -5.09628
PCNA proliferating cell nuclear antigen -5.0
TCTA T-cell leukemia translocation altered -4.268
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -4.01311
PRKX protein kinase, X-linked -3.81177
NRIP1 nuclear receptor interacting protein 1 -3.7553
RPS5 ribosomal protein S5 -3.6243
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -3.44525
KDM5C lysine (K)-specific demethylase 5C -3.35695
DDRGK1 DDRGK domain containing 1 -3.26885
SMC1A structural maintenance of chromosomes 1A -3.0411
IFRD2 interferon-related developmental regulator 2 -3.0215
GAB2 GRB2-associated binding protein 2 -3.00585
TMEM230 transmembrane protein 230 -2.8757
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 -2.8135
FBXO21 F-box protein 21 -2.80228
USP9X ubiquitin specific peptidase 9, X-linked -2.7451
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.6623
NSFL1C NSFL1 (p97) cofactor (p47) -2.6527
PER3 period circadian clock 3 -2.61525
TGM4 transglutaminase 4 -2.6123
CXCL3 chemokine (C-X-C motif) ligand 3 -2.6094
NCOA6 nuclear receptor coactivator 6 -2.6024
PUDP pseudouridine 5'-phosphatase -2.57425
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.56065
ALG11 ALG11, alpha-1,2-mannosyltransferase -2.5316
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae) -2.5199
KRT14 keratin 14, type I -2.49495
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -2.45642
CPZ carboxypeptidase Z -2.44355
PANK2 pantothenate kinase 2 -2.4288
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -2.37555
PSD3 pleckstrin and Sec7 domain containing 3 -2.34022
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -2.33652
TMEM135 transmembrane protein 135 -2.32055
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -2.31985
PCID2 PCI domain containing 2 -2.28015
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 -2.27923
TMEM258 transmembrane protein 258 -2.27015
AHCYL1 adenosylhomocysteinase-like 1 -2.26878
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.25985
COL16A1 collagen, type XVI, alpha 1 -2.2541
MAVS mitochondrial antiviral signaling protein -2.2277
TRIM44 tripartite motif containing 44 -2.21033
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 -2.2005
APIP APAF1 interacting protein -2.18675
NXF3 nuclear RNA export factor 3 -2.178
GTPBP6 GTP binding protein 6 (putative) -2.1675
CLNS1A chloride channel, nucleotide-sensitive, 1A -2.1562
MYO5A myosin VA (heavy chain 12, myoxin) -2.1522
POGLUT2 protein O-glucosyltransferase 2 -2.1488
OFD1 oral-facial-digital syndrome 1 -2.14555
F7 coagulation factor VII (serum prothrombin conversion accelerator) -2.134
IRS2 insulin receptor substrate 2 -2.13002
KIZ kizuna centrosomal protein -2.09845
SNX5 sorting nexin 5 -2.0717
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -2.0561
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -2.0519
KDM6A lysine (K)-specific demethylase 6A -2.04268
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B -2.0359
LYPD1 LY6/PLAUR domain containing 1 -2.02765
DPF2 D4, zinc and double PHD fingers family 2 -2.02405
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) -2.02108
ZCCHC24 zinc finger, CCHC domain containing 24 -2.01748
NOP56 NOP56 ribonucleoprotein -2.01685
ZBED2 zinc finger, BED-type containing 2 -2.0089
ZPR1 ZPR1 zinc finger -2.00887
PDE1A phosphodiesterase 1A, calmodulin-dependent -2.0033