CRCGN015_MCF10A.TP53.M_24H:O19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sulfallate 100.72 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

82 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:O19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 5.15602
CDCA4 cell division cycle associated 4 5.1213
ALDOC aldolase C, fructose-bisphosphate 4.72985
TBX2 T-box 2 4.44803
UGDH UDP-glucose 6-dehydrogenase 4.33595
ACAA1 acetyl-CoA acyltransferase 1 3.38695
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) 2.59425
WDR41 WD repeat domain 41 2.56965
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) 2.5639
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 2.52495
SREK1IP1 SREK1-interacting protein 1 2.4387
C4BPB complement component 4 binding protein, beta 2.4057
MRPL17 mitochondrial ribosomal protein L17 2.40495
MBNL1 muscleblind-like splicing regulator 1 2.32694
TUBA3C tubulin, alpha 3c 2.30605
BAAT bile acid CoA:amino acid N-acyltransferase 2.284
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.22825
DCPH1 damage control phosphatase 1 2.2137
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9 2.2022
CREB1 cAMP responsive element binding protein 1 2.18699
ACSL5 acyl-CoA synthetase long-chain family member 5 2.176
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.17205
VAMP8 vesicle-associated membrane protein 8 2.1714
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 2.167
LGMN legumain 2.158
POLR2H polymerase (RNA) II (DNA directed) polypeptide H 2.1556
MRPL9 mitochondrial ribosomal protein L9 2.13928
FBP1 fructose-1,6-bisphosphatase 1 2.1173
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.1117
NISCH nischarin 2.0992
STAC SH3 and cysteine rich domain 2.0987
PEF1 penta-EF-hand domain containing 1 2.07125
AAAS achalasia, adrenocortical insufficiency, alacrimia 2.0665
PPP1R13L protein phosphatase 1, regulatory subunit 13 like 2.06075
TBXT T-box transcription factor T 2.0326
PIEZO2 piezo-type mechanosensitive ion channel component 2 2.0303
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2 2.02255
CCNDBP1 cyclin D-type binding-protein 1 2.0118

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -5.553
PUF60 poly-U binding splicing factor 60KDa -5.4501
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -5.1568
TSPAN4 tetraspanin 4 -5.05185
MSMO1 methylsterol monooxygenase 1 -5.0
ADI1 acireductone dioxygenase 1 -4.47915
UBE3C ubiquitin protein ligase E3C -4.4196
EXOSC4 exosome component 4 -3.4376
RPS5 ribosomal protein S5 -3.03185
MTERF3 mitochondrial transcription termination factor 3 -2.99165
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -2.98265
BCAP29 B-cell receptor-associated protein 29 -2.95965
COX6C cytochrome c oxidase subunit VIc -2.8956
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa -2.8784
MACF1 microtubule-actin crosslinking factor 1 -2.80581
NCAPG2 non-SMC condensin II complex, subunit G2 -2.56505
BMAL1 basic helix-loop-helix ARNT like 1 -2.55118
BASP1 brain abundant, membrane attached signal protein 1 -2.4819
SCRIB scribbled planar cell polarity protein -2.47715
DUS4L dihydrouridine synthase 4-like (S. cerevisiae) -2.45498
TMEM267 transmembrane protein 267 -2.44505
GIGYF2 GRB10 interacting GYF protein 2 -2.44478
LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.402
ZMPSTE24 zinc metallopeptidase STE24 -2.40085
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.39845
PELI2 pellino E3 ubiquitin protein ligase family member 2 -2.36355
GCC1 GRIP and coiled-coil domain containing 1 -2.32665
IRX4 iroquois homeobox 4 -2.3136
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase -2.30415
BACE1 beta-site APP-cleaving enzyme 1 -2.29985
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -2.29705
LPIN1 lipin 1 -2.28245
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 -2.23225
ZNHIT6 zinc finger, HIT-type containing 6 -2.22655
SLC39A4 solute carrier family 39 (zinc transporter), member 4 -2.2218
WDR70 WD repeat domain 70 -2.19725
COG5 component of oligomeric golgi complex 5 -2.18395
WRN Werner syndrome, RecQ helicase-like -2.17485
IPO13 importin 13 -2.1316
SEM1 SEM1 26S proteasome subunit -2.0992
RNF144A ring finger protein 144A -2.0676
DHCR7 7-dehydrocholesterol reductase -2.03323
INTS8 integrator complex subunit 8 -2.0299
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -2.01128