CRCGN015_MCF10A.TP53.M_24H:O20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sulfallate 33.57 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

47 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:O20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 5.0948
LGMN legumain 4.76495
CGRRF1 cell growth regulator with ring finger domain 1 4.31865
INTS3 integrator complex subunit 3 4.1164
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 3.7902
LYN LYN proto-oncogene, Src family tyrosine kinase 3.4761
ACAA1 acetyl-CoA acyltransferase 1 3.45462
MKNK1 MAP kinase interacting serine/threonine kinase 1 3.2335
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 2.9573
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.90605
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) 2.8005
CORO1A coronin, actin binding protein, 1A 2.5048
SGPP1 sphingosine-1-phosphate phosphatase 1 2.37165
PRR7 proline rich 7 (synaptic) 2.325
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.28685
GSTZ1 glutathione S-transferase zeta 1 2.2468
HIPK3 homeodomain interacting protein kinase 3 2.23333
GTPBP8 GTP-binding protein 8 (putative) 2.1996
NMD3 NMD3 ribosome export adaptor 2.1904
PUS1 pseudouridylate synthase 1 2.1874
ADGRG1 adhesion G protein-coupled receptor G1 2.14717
TMOD3 tropomodulin 3 (ubiquitous) 2.14705
HPR haptoglobin-related protein 2.09355
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 2.0853
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 2.04425
NT5DC2 5'-nucleotidase domain containing 2 2.02655
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 2.0171
P2RY10 purinergic receptor P2Y, G-protein coupled, 10 2.01675

decreased expression

Symbol Name Standardized Value
C2CD5 C2 calcium-dependent domain containing 5 -5.49655
BLCAP bladder cancer associated protein -4.22625
HSPA1A heat shock 70kDa protein 1A -3.54125
IPO13 importin 13 -2.947
ELAC2 elaC ribonuclease Z 2 -2.79785
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.60535
RPN1 ribophorin I -2.5691
STXBP2 syntaxin binding protein 2 -2.34425
GARRE1 granule associated Rac and RHOG effector 1 -2.25945
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.1918
GRN granulin -2.15612
TECR trans-2,3-enoyl-CoA reductase -2.0912
AATF apoptosis antagonizing transcription factor -2.04685
NUDC nudC nuclear distribution protein -2.02915
RPS5 ribosomal protein S5 -2.02835
SART1 squamous cell carcinoma antigen recognized by T cells -2.02005
NUP93 nucleoporin 93kDa -2.01995
NAV3 neuron navigator 3 -2.01475
CD320 CD320 molecule -2.00955