CRCGN015_MCF10A.TP53.M_24H:O21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sulfallate 11.19 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

118 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:O21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
EAPP E2F-associated phosphoprotein 5.607
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.93735
ZNF589 zinc finger protein 589 3.73617
SNX11 sorting nexin 11 3.73615
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 3.5172
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 3.13077
GPER1 G protein-coupled estrogen receptor 1 2.96653
COMP cartilage oligomeric matrix protein 2.9408
SPTSSA serine palmitoyltransferase, small subunit A 2.84505
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.7916
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.6834
IMPACT impact RWD domain protein 2.64
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 2.61865
NIPAL2 NIPA-like domain containing 2 2.5809
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 2.5493
PEX26 peroxisomal biogenesis factor 26 2.54665
TMEM242 transmembrane protein 242 2.5208
NOSIP nitric oxide synthase interacting protein 2.5069
DAND5 DAN domain family member 5, BMP antagonist 2.49515
BAX BCL2-associated X protein 2.48855
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 2.466
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 2.45485
WDR5B WD repeat domain 5B 2.41125
ND5 NADH dehydrogenase subunit 5 2.40395
CA7 carbonic anhydrase VII 2.39075
CAPN1 calpain 1, (mu/I) large subunit 2.37865
ZKSCAN3 zinc finger with KRAB and SCAN domains 3 2.3727
ELAC1 elaC ribonuclease Z 1 2.37225
ZBTB44 zinc finger and BTB domain containing 44 2.32805
ZNF669 zinc finger protein 669 2.3168
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 2.315
EPAS1 endothelial PAS domain protein 1 2.30323
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 2.2945
GADD45A growth arrest and DNA-damage-inducible, alpha 2.28735
BSN bassoon presynaptic cytomatrix protein 2.27385
NPTX1 neuronal pentraxin I 2.2738
BAK1 BCL2-antagonist/killer 1 2.2719
SCN3B sodium channel, voltage gated, type III beta subunit 2.2562
KITLG KIT ligand 2.25563
TOPBP1 topoisomerase (DNA) II binding protein 1 2.24375
PHACTR1 phosphatase and actin regulator 1 2.2402
ZNF140 zinc finger protein 140 2.23405
PRAMEF26 PRAME family member 26 2.2294
CADM1 cell adhesion molecule 1 2.2267
CCDC85B coiled-coil domain containing 85B 2.21395
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2 2.208
XDH xanthine dehydrogenase 2.20345
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2.19502
ARL4C ADP-ribosylation factor-like 4C 2.19335
WDR7 WD repeat domain 7 2.1932
LDAH lipid droplet associated hydrolase 2.18567
WWC2 WW and C2 domain containing 2 2.1791
RTN2 reticulon 2 2.1673
ZG16 zymogen granule protein 16 2.1647
AKT2 v-akt murine thymoma viral oncogene homolog 2 2.16188
PTK2B protein tyrosine kinase 2 beta 2.15645
SLC26A4 solute carrier family 26 (anion exchanger), member 4 2.145
PLA2G3 phospholipase A2, group III 2.12575
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase 2.12555
ANKRD44 ankyrin repeat domain 44 2.12155
HTRA1 HtrA serine peptidase 1 2.12155
AOC1 amine oxidase, copper containing 1 2.1204
CMKLR1 chemerin chemokine-like receptor 1 2.11613
ATXN7L3B ataxin 7-like 3B 2.11525
FBXL2 F-box and leucine-rich repeat protein 2 2.11155
DHRS9 dehydrogenase/reductase (SDR family) member 9 2.11095
BTBD8 BTB (POZ) domain containing 8 2.10165
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit 2.0964
CCNG2 cyclin G2 2.07727
UNC13A unc-13 homolog A (C. elegans) 2.07565
MAPK10 mitogen-activated protein kinase 10 2.07265
ZNF223 zinc finger protein 223 2.0581
HACD3 3-hydroxyacyl-CoA dehydratase 3 2.0556
PRORP protein only RNase P catalytic subunit 2.05378
TRAFD1 TRAF-type zinc finger domain containing 1 2.0514
CFAP69 cilia and flagella associated protein 69 2.04995
SSBP3 single stranded DNA binding protein 3 2.04865
GSTM2 glutathione S-transferase mu 2 (muscle) 2.04382
LHX2 LIM homeobox 2 2.03918
LY6H lymphocyte antigen 6 complex, locus H 2.03675
PHKG2 phosphorylase kinase, gamma 2 (testis) 2.03595
KCTD20 potassium channel tetramerization domain containing 20 2.02955
RASAL1 RAS protein activator like 1 (GAP1 like) 2.0225
CLEC10A C-type lectin domain family 10, member A 2.02225
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 2.0204
LYRM9 LYR motif containing 9 2.0116
NCS1 neuronal calcium sensor 1 2.01025
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 2.0041
CCP110 centriolar coiled coil protein 110kDa 2.00405
MCAT malonyl CoA:ACP acyltransferase (mitochondrial) 2.00285

decreased expression

Symbol Name Standardized Value
KIF14 kinesin family member 14 -5.6366
KRT14 keratin 14, type I -5.0
ISOC1 isochorismatase domain containing 1 -4.25065
HSPA1A heat shock 70kDa protein 1A -4.0468
ANKRD10 ankyrin repeat domain 10 -3.97805
JMJD6 jumonji domain containing 6 -3.73737
PSIP1 PC4 and SFRS1 interacting protein 1 -3.62148
CD320 CD320 molecule -3.50315
CRTAP cartilage associated protein -3.49795
CD81 CD81 molecule -3.0128
TMEM109 transmembrane protein 109 -2.7677
MXRA7 matrix-remodelling associated 7 -2.70875
BLCAP bladder cancer associated protein -2.69365
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative) -2.68505
GLB1 galactosidase, beta 1 -2.47535
ZFP36 ZFP36 ring finger protein -2.382
TSPAN3 tetraspanin 3 -2.2949
ORC6 origin recognition complex, subunit 6 -2.26435
THAP11 THAP domain containing 11 -2.24535
SUCO SUN domain containing ossification factor -2.2148
RPN2 ribophorin II -2.141
RPS5 ribosomal protein S5 -2.12875
KDM3A lysine (K)-specific demethylase 3A -2.1169
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 -2.07515
VLDLR very low density lipoprotein receptor -2.0162
BAG2 BCL2-associated athanogene 2 -2.01045
MSX1 msh homeobox 1 -2.00485
LMO2 LIM domain only 2 (rhombotin-like 1) -2.00175