CRCGN015_MCF10A.TP53.M_24H:P01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description acedapsone 98.29 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

103 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:P01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CNPY3 canopy FGF signaling regulator 3 5.30947
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 5.26831
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 5.2165
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 5.20301
ADGRE5 adhesion G protein-coupled receptor E5 4.65501
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.64221
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 4.64165
IPO13 importin 13 4.41308
IDE insulin-degrading enzyme 4.2035
ARID5B AT rich interactive domain 5B (MRF1-like) 3.93148
HBB hemoglobin, beta 3.21573
RTN2 reticulon 2 3.2103
HTRA1 HtrA serine peptidase 1 3.12283
HBA1 hemoglobin, alpha 1 3.11907
ACAA1 acetyl-CoA acyltransferase 1 3.02967
PPP1R13L protein phosphatase 1, regulatory subunit 13 like 2.63754
NGB neuroglobin 2.611
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.60641
GINS4 GINS complex subunit 4 (Sld5 homolog) 2.58537
DRC4 dynein regulatory complex subunit 4 2.44283
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 2.35053
PKN1 protein kinase N1 2.34329
VGLL4 vestigial-like family member 4 2.34035
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.31947
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) 2.31208
PHKG1 phosphorylase kinase, gamma 1 (muscle) 2.29065
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.28828
FRS3 fibroblast growth factor receptor substrate 3 2.24864
SLC4A3 solute carrier family 4 (anion exchanger), member 3 2.22217
ZFR2 zinc finger RNA binding protein 2 2.20932
RUSC2 RUN and SH3 domain containing 2 2.19989
KIF17 kinesin family member 17 2.19887
RFC5 replication factor C (activator 1) 5, 36.5kDa 2.19496
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 2.18135
AUNIP aurora kinase A and ninein interacting protein 2.17911
BYSL bystin-like 2.15401
TNNI1 troponin I type 1 (skeletal, slow) 2.15255
WDR76 WD repeat domain 76 2.13795
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa 2.13625
CKM creatine kinase, muscle 2.11311
GHR growth hormone receptor 2.10764
PSG7 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene) 2.10296
MARCHF5 membrane associated ring-CH-type finger 5 2.09961
TPM3 tropomyosin 3 2.0982
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 2.09696
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa 2.0803
AQP5 aquaporin 5 2.06985
P3H3 prolyl 3-hydroxylase 3 2.05768
CALB2 calbindin 2 2.05604
CPAP centrosome assembly and centriole elongation protein 2.04747
PYGM phosphorylase, glycogen, muscle 2.03485
CNTN2 contactin 2 (axonal) 2.03304
CADM1 cell adhesion molecule 1 2.02939
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.02873
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 2.02837
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14 2.02422
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like 2.02419
CLDN11 claudin 11 2.02224
S100A4 S100 calcium binding protein A4 2.0218
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein 2.01048
IRF2BP1 interferon regulatory factor 2 binding protein 1 2.00695
TNNT1 troponin T type 1 (skeletal, slow) 2.00542
SLC12A8 solute carrier family 12, member 8 2.00399
CLK3 CDC-like kinase 3 2.00087

decreased expression

Symbol Name Standardized Value
RNF167 ring finger protein 167 -5.38618
RPS5 ribosomal protein S5 -4.90876
ENOPH1 enolase-phosphatase 1 -4.65534
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.88811
ATF5 activating transcription factor 5 -3.6592
COG2 component of oligomeric golgi complex 2 -3.65568
MSMO1 methylsterol monooxygenase 1 -3.29509
COQ9 coenzyme Q9 -3.073
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -3.05402
MSRA methionine sulfoxide reductase A -3.01106
TMEM106B transmembrane protein 106B -2.99664
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -2.63178
SLC9B2 solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 -2.61526
CAPN2 calpain 2, (m/II) large subunit -2.55653
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -2.54504
THAP11 THAP domain containing 11 -2.5227
KRT14 keratin 14, type I -2.49083
EYA1 EYA transcriptional coactivator and phosphatase 1 -2.36892
CRTAP cartilage associated protein -2.34545
FBXO21 F-box protein 21 -2.34195
PCCB propionyl CoA carboxylase, beta polypeptide -2.33739
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa -2.23609
AP1AR adaptor-related protein complex 1 associated regulatory protein -2.22483
DLL3 delta-like 3 (Drosophila) -2.21339
BCHE butyrylcholinesterase -2.19913
PLA2G12A phospholipase A2, group XIIA -2.197
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.19452
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 -2.1684
REXO2 RNA exonuclease 2 -2.13681
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 -2.12092
SEC31A SEC31 homolog A (S. cerevisiae) -2.07674
CLCN3 chloride channel, voltage-sensitive 3 -2.0716
CLOCK clock circadian regulator -2.05666
FADS2 fatty acid desaturase 2 -2.04736
COG4 component of oligomeric golgi complex 4 -2.03477
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -2.0269
INTS12 integrator complex subunit 12 -2.01815
SMAD5 SMAD family member 5 -2.0139
IPP intracisternal A particle-promoted polypeptide -2.00877