CRCGN015_MCF10A.TP53.M_24H:P02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description acedapsone 32.76 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:P02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CNRIP1 cannabinoid receptor interacting protein 1 4.71374
FKBP14 FK506 binding protein 14, 22 kDa 4.6823
CHMP6 charged multivesicular body protein 6 3.76666
ZNF586 zinc finger protein 586 3.60256
SNAP25 synaptosomal-associated protein, 25kDa 3.39265
ZNF134 zinc finger protein 134 3.27394
CCDC92 coiled-coil domain containing 92 2.95586
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.78651
TIAM1 T-cell lymphoma invasion and metastasis 1 2.72633
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.70184
TPD52L2 tumor protein D52-like 2 2.63622
WIF1 WNT inhibitory factor 1 2.6331
GADD45A growth arrest and DNA-damage-inducible, alpha 2.57438
GATA3 GATA binding protein 3 2.56197
IGHMBP2 immunoglobulin mu binding protein 2 2.55692
CSNK1A1 casein kinase 1, alpha 1 2.52478
ZNF587 zinc finger protein 587 2.48516
MTA2 metastasis associated 1 family, member 2 2.42053
AGR2 anterior gradient 2 2.3989
ZNF587B zinc finger protein 587B 2.37283
ZNF551 zinc finger protein 551 2.35681
ZNF329 zinc finger protein 329 2.2109
SLC35F2 solute carrier family 35, member F2 2.17845
PCDHB3 protocadherin beta 3 2.08577
CXCL2 chemokine (C-X-C motif) ligand 2 2.00112

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -3.88248
ACAA1 acetyl-CoA acyltransferase 1 -3.73042
TRAPPC3 trafficking protein particle complex 3 -3.37383
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.29227
COG2 component of oligomeric golgi complex 2 -3.24195
CAB39 calcium binding protein 39 -3.01157
HSPA8 heat shock 70kDa protein 8 -2.84871
KIF14 kinesin family member 14 -2.67987
LYPLA1 lysophospholipase I -2.65645
FPGS folylpolyglutamate synthase -2.57898
COTL1 coactosin-like F-actin binding protein 1 -2.23842
NT5DC2 5'-nucleotidase domain containing 2 -2.20806
RAD51C RAD51 paralog C -2.11957
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -2.10233
BASP1 brain abundant, membrane attached signal protein 1 -2.06736
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.06553
MSRA methionine sulfoxide reductase A -2.00519