CRCGN015_MCF10A.TP53.M_24H:P03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description acedapsone 10.92 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

35 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:P03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 5.69086
ADGRE5 adhesion G protein-coupled receptor E5 3.84168
WFS1 Wolfram syndrome 1 (wolframin) 3.65025
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 3.46779
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 3.34625
MAMLD1 mastermind-like domain containing 1 3.28452
CCNA1 cyclin A1 3.17125
ZBTB35 zinc finger and BTB domain containing 35 2.58112
EML3 echinoderm microtubule associated protein like 3 2.49217
TRAPPC4 trafficking protein particle complex 4 2.47665
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.46885
SYNE2 spectrin repeat containing, nuclear envelope 2 2.35496
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.28226
GHR growth hormone receptor 2.25276
PTPRG protein tyrosine phosphatase, receptor type, G 2.19737
ADRB2 adrenoceptor beta 2, surface 2.105
FGFR4 fibroblast growth factor receptor 4 2.08871
CNPY3 canopy FGF signaling regulator 3 2.03691

decreased expression

Symbol Name Standardized Value
NUSAP1 nucleolar and spindle associated protein 1 -4.61366
HAT1 histone acetyltransferase 1 -3.98714
VDAC1 voltage-dependent anion channel 1 -3.80727
LYPLA1 lysophospholipase I -3.77587
LAP3 leucine aminopeptidase 3 -3.73341
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -3.68491
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -3.35275
HEATR1 HEAT repeat containing 1 -2.90856
NGRN neugrin, neurite outgrowth associated -2.73256
COTL1 coactosin-like F-actin binding protein 1 -2.60853
HMG20B high mobility group 20B -2.49209
MSN moesin -2.45174
RNF167 ring finger protein 167 -2.43839
SGK1 serum/glucocorticoid regulated kinase 1 -2.38184
TAC4 tachykinin 4 (hemokinin) -2.37319
ENOPH1 enolase-phosphatase 1 -2.28674
MFAP1 microfibrillar-associated protein 1 -2.21153