CRCGN015_MCF10A.TP53.M_24H:P10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description megestrol 99.64 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

156 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:P10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.89905
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.5258
MSRA methionine sulfoxide reductase A 4.35605
SYNGAP1 synaptic Ras GTPase activating protein 1 4.08875
IL1B interleukin 1, beta 4.0857
KIF5C kinesin family member 5C 3.65898
FGFR4 fibroblast growth factor receptor 4 3.61795
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 3.47645
IER3 immediate early response 3 3.454
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 3.427
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 3.36497
FHL2 four and a half LIM domains 2 3.28895
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 3.1103
RAB13 RAB13, member RAS oncogene family 3.0069
CRLF1 cytokine receptor-like factor 1 2.9543
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 2.94477
MDM4 MDM4, p53 regulator 2.8922
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.87755
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.8516
CENPE centromere protein E, 312kDa 2.83385
PDGFA platelet-derived growth factor alpha polypeptide 2.76192
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 2.76086
INSIG1 insulin induced gene 1 2.7207
CERK ceramide kinase 2.7116
PYGL phosphorylase, glycogen, liver 2.7077
LGMN legumain 2.695
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.65228
ZBED2 zinc finger, BED-type containing 2 2.5999
AGR2 anterior gradient 2 2.5816
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 2.4868
RYK receptor-like tyrosine kinase 2.47367
SAV1 salvador family WW domain containing protein 1 2.4289
HNRNPL heterogeneous nuclear ribonucleoprotein L 2.38735
DCBLD2 discoidin, CUB and LCCL domain containing 2 2.38665
AKAP12 A kinase (PRKA) anchor protein 12 2.3819
MTA2 metastasis associated 1 family, member 2 2.3743
UBA6 ubiquitin-like modifier activating enzyme 6 2.3743
CALCA calcitonin-related polypeptide alpha 2.37381
CALCB calcitonin-related polypeptide beta 2.36355
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 2.3453
TMEM209 transmembrane protein 209 2.34005
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 2.3346
WIF1 WNT inhibitory factor 1 2.29935
CALU calumenin 2.28435
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.2632
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.25345
KCTD5 potassium channel tetramerization domain containing 5 2.2511
CYTH1 cytohesin 1 2.2494
SH3D19 SH3 domain containing 19 2.2367
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 2.22897
CEPT1 choline/ethanolamine phosphotransferase 1 2.22385
NUTF2 nuclear transport factor 2 2.2136
LIPG lipase, endothelial 2.18945
HP1BP3 heterochromatin protein 1, binding protein 3 2.17625
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 2.1452
TGFBR1 transforming growth factor, beta receptor 1 2.13485
PTPRE protein tyrosine phosphatase, receptor type, E 2.1144
TGIF1 TGFB-induced factor homeobox 1 2.10395
DYNLT1 dynein, light chain, Tctex-type 1 2.09555
CTAGE8 CTAGE family, member 8 2.09395
SV2A synaptic vesicle glycoprotein 2A 2.08935
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) 2.0706
CERS6 ceramide synthase 6 2.05312
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 2.0464
COPG1 coatomer protein complex, subunit gamma 1 2.04615
STK32B serine/threonine kinase 32B 2.03395
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.032
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.03095
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 2.0269
DPH2 DPH2 homolog (S. cerevisiae) 2.01705
GCLM glutamate-cysteine ligase, modifier subunit 2.0117
ATAD2 ATPase family, AAA domain containing 2 2.01065

decreased expression

Symbol Name Standardized Value
DHRS7 dehydrogenase/reductase (SDR family) member 7 -10.0
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -4.96883
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -4.66275
SLC25A46 solute carrier family 25, member 46 -4.444
KIF14 kinesin family member 14 -4.09595
ANKRD10 ankyrin repeat domain 10 -3.61315
ADRB2 adrenoceptor beta 2, surface -3.5552
PMM2 phosphomannomutase 2 -3.52365
PRR15L proline rich 15-like -3.4469
RGS2 regulator of G-protein signaling 2 -3.2661
RALGDS ral guanine nucleotide dissociation stimulator -3.16622
ACAA1 acetyl-CoA acyltransferase 1 -3.16283
BPHL biphenyl hydrolase-like (serine hydrolase) -3.07735
KDM3A lysine (K)-specific demethylase 3A -3.0148
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 -2.96485
OR51E2 olfactory receptor, family 51, subfamily E, member 2 -2.871
GADD45B growth arrest and DNA-damage-inducible, beta -2.8642
FZD2 frizzled class receptor 2 -2.8216
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.7496
ZSCAN5A zinc finger and SCAN domain containing 5A -2.73665
OSR2 odd-skipped related transciption factor 2 -2.6746
ATG4A autophagy related 4A, cysteine peptidase -2.60785
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.48502
ACAD8 acyl-CoA dehydrogenase family, member 8 -2.47355
HSPA6 heat shock 70kDa protein 6 (HSP70B') -2.45913
RGS20 regulator of G-protein signaling 20 -2.43775
SCTR secretin receptor -2.42315
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -2.41765
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.39912
ADAT1 adenosine deaminase, tRNA-specific 1 -2.38105
ZKSCAN2 zinc finger with KRAB and SCAN domains 2 -2.376
RNFT1-DT RNFT1 divergent transcript -2.37345
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.3621
ADGRF5 adhesion G protein-coupled receptor F5 -2.34238
FGD6 FYVE, RhoGEF and PH domain containing 6 -2.33555
DDIT4 DNA-damage-inducible transcript 4 -2.31475
E4F1 E4F transcription factor 1 -2.3063
OLFML1 olfactomedin-like 1 -2.28425
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) -2.2763
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -2.2563
SGK1 serum/glucocorticoid regulated kinase 1 -2.25555
HMOX2 heme oxygenase 2 -2.25402
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa -2.24815
LIFR leukemia inhibitory factor receptor alpha -2.23085
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa -2.2266
GOLM1 golgi membrane protein 1 -2.2232
IGF1 insulin-like growth factor 1 (somatomedin C) -2.21761
TBCE tubulin folding cofactor E -2.21033
TAOK3 TAO kinase 3 -2.20755
BBS10 Bardet-Biedl syndrome 10 -2.2051
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7 -2.20005
ZNHIT1 zinc finger, HIT-type containing 1 -2.17405
PRPF31 pre-mRNA processing factor 31 -2.16823
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -2.16488
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) -2.16265
HOXB7 homeobox B7 -2.16227
FES FES proto-oncogene, tyrosine kinase -2.16075
MAGEA11 melanoma antigen family A11 -2.15835
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.14215
ZNF227 zinc finger protein 227 -2.12005
TSC22D3 TSC22 domain family, member 3 -2.116
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.11555
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 -2.1146
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7 -2.11095
SIGMAR1 sigma non-opioid intracellular receptor 1 -2.08645
TMLHE trimethyllysine hydroxylase, epsilon -2.081
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa -2.07295
TDG thymine-DNA glycosylase -2.0706
HSPA1A heat shock 70kDa protein 1A -2.0621
PDGFRL platelet-derived growth factor receptor-like -2.05995
SIX3 SIX homeobox 3 -2.0561
POLR3B polymerase (RNA) III (DNA directed) polypeptide B -2.0547
ZNF268 zinc finger protein 268 -2.0528
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia) -2.0482
PBK PDZ binding kinase -2.047
PRODH proline dehydrogenase (oxidase) 1 -2.046
MEOX1 mesenchyme homeobox 1 -2.0452
DHRS7B dehydrogenase/reductase (SDR family) member 7B -2.0405
BIN2 bridging integrator 2 -2.028
ZNF140 zinc finger protein 140 -2.0223
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26 -2.02215
ZBTB24 zinc finger and BTB domain containing 24 -2.0168
ERBIN erbb2 interacting protein -2.01255
WDR46 WD repeat domain 46 -2.0012