CRCGN015_MCF10A.TP53.M_24H:P11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description megestrol 33.21 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

336 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:P11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 10.0
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 10.0
ATP11B ATPase, class VI, type 11B 4.6193
IL1B interleukin 1, beta 4.6163
CETN3 centrin, EF-hand protein, 3 4.5515
GET1 guided entry of tail-anchored proteins factor 1 4.1656
DENND2D DENN/MADD domain containing 2D 4.1309
FHL2 four and a half LIM domains 2 4.1097
IER3 immediate early response 3 3.9485
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.8049
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 3.79735
NUCB2 nucleobindin 2 3.6855
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.4696
ADIPOR2 adiponectin receptor 2 3.3614
SYNE3 spectrin repeat containing, nuclear envelope family member 3 3.2327
GOLT1B golgi transport 1B 3.1963
PITPNB phosphatidylinositol transfer protein, beta 3.0707
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 3.0603
CLTC clathrin, heavy chain (Hc) 3.0322
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.0199
SAV1 salvador family WW domain containing protein 1 2.984
SYNGAP1 synaptic Ras GTPase activating protein 1 2.92585
DDR1 discoidin domain receptor tyrosine kinase 1 2.81068
INSIG1 insulin induced gene 1 2.80947
ADGRG1 adhesion G protein-coupled receptor G1 2.8063
PFDN2 prefoldin subunit 2 2.6497
GALE UDP-galactose-4-epimerase 2.6352
INPP1 inositol polyphosphate-1-phosphatase 2.6266
IL1A interleukin 1, alpha 2.6187
NAV3 neuron navigator 3 2.5982
BAD BCL2-associated agonist of cell death 2.5801
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 2.5611
SLIT2 slit homolog 2 (Drosophila) 2.551
DAD1 defender against cell death 1 2.5184
MALT1 MALT1 paracaspase 2.49967
LAMB3 laminin, beta 3 2.49
DUSP6 dual specificity phosphatase 6 2.48757
ARCN1 archain 1 2.4851
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 2.4839
PLAU plasminogen activator, urokinase 2.47885
PYGL phosphorylase, glycogen, liver 2.4685
SH3D19 SH3 domain containing 19 2.464
DPY19L4 dpy-19-like 4 (C. elegans) 2.4413
CADM1 cell adhesion molecule 1 2.42747
FZD6 frizzled class receptor 6 2.4178
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 2.41263
TMEM87A transmembrane protein 87A 2.4044
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 2.40218
DUSP4 dual specificity phosphatase 4 2.39445
GSAP gamma-secretase activating protein 2.3927
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.3919
ARL8B ADP-ribosylation factor-like 8B 2.3871
CLDND1 claudin domain containing 1 2.3831
HOXA10-HOXA9 HOXA10-HOXA9 readthrough 2.3647
IL4R interleukin 4 receptor 2.3479
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial 2.3398
RAB38 RAB38, member RAS oncogene family 2.3305
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 2.3156
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 2.31465
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.3022
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.2635
EGR1 early growth response 1 2.2247
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 2.2169
HMGA2 high mobility group AT-hook 2 2.2084
ERGIC2 ERGIC and golgi 2 2.2047
FKBP14 FK506 binding protein 14, 22 kDa 2.161
KCTD5 potassium channel tetramerization domain containing 5 2.1579
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.1386
PLEK2 pleckstrin 2 2.1377
LUC7L3 LUC7-like 3 (S. cerevisiae) 2.12943
NPTX2 neuronal pentraxin II 2.1211
FAM3C family with sequence similarity 3, member C 2.1184
FCMR Fc fragment of IgM receptor 2.10895
LOC128031832 uncharacterized LOC128031832 2.108
PRMT3 protein arginine methyltransferase 3 2.1072
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.105
CARD8 caspase recruitment domain family, member 8 2.104
MCFD2 multiple coagulation factor deficiency 2 2.0928
FAM168B family with sequence similarity 168, member B 2.0903
CSNK1G3 casein kinase 1, gamma 3 2.0774
SHCBP1 SHC SH2-domain binding protein 1 2.0736
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.0664
HMGXB4 HMG box domain containing 4 2.0597
LIN7C lin-7 homolog C (C. elegans) 2.0524
DPY19L1 dpy-19-like 1 (C. elegans) 2.0523
PUM1 pumilio RNA-binding family member 1 2.0483
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 2.04703
CLCA2 chloride channel accessory 2 2.0295
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 2.0238
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.0173
LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.0105
MYDGF myeloid-derived growth factor 2.00375

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -10.0
STXBP2 syntaxin binding protein 2 -7.4866
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -7.20525
CIAPIN1 cytokine induced apoptosis inhibitor 1 -7.0762
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -5.3775
MKKS McKusick-Kaufman syndrome -5.2106
CRNKL1 crooked neck pre-mRNA splicing factor 1 -5.0206
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -4.65475
PANK2 pantothenate kinase 2 -4.6065
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.5448
RGS2 regulator of G-protein signaling 2 -4.012
PRR15L proline rich 15-like -3.9473
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -3.8605
GINS1 GINS complex subunit 1 (Psf1 homolog) -3.8443
DDRGK1 DDRGK domain containing 1 -3.8136
ELAC2 elaC ribonuclease Z 2 -3.6834
MCM6 minichromosome maintenance complex component 6 -3.673
ADRB2 adrenoceptor beta 2, surface -3.6489
NSFL1C NSFL1 (p97) cofactor (p47) -3.46243
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -3.4612
GTPBP8 GTP-binding protein 8 (putative) -3.446
OVOL2 ovo-like zinc finger 2 -3.4279
AP5S1 adaptor-related protein complex 5, sigma 1 subunit -3.4011
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 -3.2999
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -3.2285
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide -3.227
SNX5 sorting nexin 5 -3.1193
ZNF133 zinc finger protein 133 -3.11395
TMEM230 transmembrane protein 230 -3.0944
VILL villin-like -3.0731
NOP56 NOP56 ribonucleoprotein -3.07095
CCDC25 coiled-coil domain containing 25 -3.0029
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.999
TRDMT1 tRNA aspartic acid methyltransferase 1 -2.9795
SNRPB2 small nuclear ribonucleoprotein polypeptide B -2.9517
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide -2.9286
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3 -2.9145
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.9138
CAPN1 calpain 1, (mu/I) large subunit -2.9125
MCM3 minichromosome maintenance complex component 3 -2.9049
SETD6 SET domain containing 6 -2.8738
KIF1A kinesin family member 1A -2.8729
FMNL1 formin-like 1 -2.8604
C5AR1 complement component 5a receptor 1 -2.8604
ZMAT3 zinc finger, matrin-type 3 -2.8572
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.8429
LAMP5 lysosomal-associated membrane protein family, member 5 -2.8401
ADORA3 adenosine A3 receptor -2.8379
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -2.83125
COQ9 coenzyme Q9 -2.8192
VPS9D1 VPS9 domain containing 1 -2.8172
POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa -2.81197
ZWINT ZW10 interacting kinetochore protein -2.8094
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 -2.778
ANXA11 annexin A11 -2.775
CENPB centromere protein B, 80kDa -2.7726
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 -2.7643
ZFP36 ZFP36 ring finger protein -2.7503
COBL cordon-bleu WH2 repeat protein -2.7484
SEC23B Sec23 homolog B (S. cerevisiae) -2.74647
ITGB8 integrin, beta 8 -2.7431
LZTS3 leucine zipper, putative tumor suppressor family member 3 -2.7243
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) -2.7243
C1QBP complement component 1, q subcomponent binding protein -2.7189
CCNB1 cyclin B1 -2.7091
PRCP prolylcarboxypeptidase (angiotensinase C) -2.6963
SEPSECS Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase -2.68435
ADISSP adipose secreted signaling protein -2.6639
TSC22D3 TSC22 domain family, member 3 -2.6605
GINS2 GINS complex subunit 2 (Psf2 homolog) -2.6481
TYMS thymidylate synthetase -2.6466
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) -2.6447
DDX49 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 -2.6159
NAP1L2 nucleosome assembly protein 1-like 2 -2.6127
LGI1 leucine-rich, glioma inactivated 1 -2.6121
ARRB2 arrestin, beta 2 -2.6118
CLEC4E C-type lectin domain family 4, member E -2.6025
CENPT centromere protein T -2.5991
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain -2.58737
RGS1 regulator of G-protein signaling 1 -2.57855
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial -2.5654
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 -2.5646
COX5A cytochrome c oxidase subunit Va -2.5506
FRAT1 frequently rearranged in advanced T-cell lymphomas 1 -2.5447
NXT1 nuclear transport factor 2-like export factor 1 -2.5366
MEIS1 Meis homeobox 1 -2.535
ZNF304 zinc finger protein 304 -2.5268
ZDHHC7 zinc finger, DHHC-type containing 7 -2.526
FAM131B family with sequence similarity 131, member B -2.5148
CIAO2B cytosolic iron-sulfur assembly component 2B -2.5126
KIF15 kinesin family member 15 -2.5112
TRIM11 tripartite motif containing 11 -2.5053
SLC68A1 solute carrier family 68 member 1 -2.4978
MLYCD malonyl-CoA decarboxylase -2.4924
FBXL6 F-box and leucine-rich repeat protein 6 -2.4887
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.487
BID BH3 interacting domain death agonist -2.4837
KCNK1 potassium channel, two pore domain subfamily K, member 1 -2.4729
MTUS1 microtubule associated tumor suppressor 1 -2.46847
CEP162 centrosomal protein 162kDa -2.46415
CDH10 cadherin 10, type 2 (T2-cadherin) -2.4638
MPPED2 metallophosphoesterase domain containing 2 -2.4534
COMMD9 COMM domain containing 9 -2.4525
TCEA2 transcription elongation factor A (SII), 2 -2.4471
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.4464
CD53 CD53 molecule -2.4457
CALHM2 calcium homeostasis modulator 2 -2.443
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae) -2.4356
PNPLA6 patatin-like phospholipase domain containing 6 -2.4353
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -2.42585
MCM7 minichromosome maintenance complex component 7 -2.425
VASH2 vasohibin 2 -2.4191
AKTIP AKT interacting protein -2.4166
KIZ kizuna centrosomal protein -2.4149
IL17RB interleukin 17 receptor B -2.4091
SLC39A4 solute carrier family 39 (zinc transporter), member 4 -2.4077
EPCIP exosomal polycystin 1 interacting protein -2.406
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) -2.4056
KIAA0513 KIAA0513 -2.3816
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -2.37935
PNMA8A PNMA family member 8A -2.371
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -2.364
DIRAS2 DIRAS family, GTP-binding RAS-like 2 -2.3604
PM20D1 peptidase M20 domain containing 1 -2.3563
CAND2 cullin-associated and neddylation-dissociated 2 (putative) -2.3491
FAM32A family with sequence similarity 32, member A -2.3447
NQO2 NAD(P)H dehydrogenase, quinone 2 -2.3317
GPR183 G protein-coupled receptor 183 -2.3195
GNG3 guanine nucleotide binding protein (G protein), gamma 3 -2.3153
FRAT2 frequently rearranged in advanced T-cell lymphomas 2 -2.3097
MAVS mitochondrial antiviral signaling protein -2.3095
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) -2.3091
MGAM maltase-glucoamylase -2.3065
MUC1 mucin 1, cell surface associated -2.3065
TRAIP TRAF interacting protein -2.3012
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 -2.29925
RNF24 ring finger protein 24 -2.29667
MAPT microtubule-associated protein tau -2.29658
PAMR1 peptidase domain containing associated with muscle regeneration 1 -2.2908
RPAP2 RNA polymerase II associated protein 2 -2.2895
CDKN2AIP CDKN2A interacting protein -2.2892
ALOX5AP arachidonate 5-lipoxygenase-activating protein -2.2697
UBOX5 U-box domain containing 5 -2.26575
THOC7 THO complex 7 -2.2651
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -2.2645
HAMP hepcidin antimicrobial peptide -2.2634
CENPU centromere protein U -2.2511
EYA2 EYA transcriptional coactivator and phosphatase 2 -2.2445
CTSF cathepsin F -2.24
KLHDC4 kelch domain containing 4 -2.2396
ZSCAN26 zinc finger and SCAN domain containing 26 -2.2354
BRD7 bromodomain containing 7 -2.2345
TMEM242 transmembrane protein 242 -2.2272
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 -2.2215
NINL ninein-like -2.2202
SCD5 stearoyl-CoA desaturase 5 -2.2199
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26 -2.2174
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 -2.2158
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A -2.2154
CHMP1A charged multivesicular body protein 1A -2.2148
UNC13D unc-13 homolog D (C. elegans) -2.2095
ADD3 adducin 3 (gamma) -2.2079
PTH2R parathyroid hormone 2 receptor -2.2076
TYROBP TYRO protein tyrosine kinase binding protein -2.2039
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 -2.2027
RTF2 replication termination factor 2 -2.2011
PANK4 pantothenate kinase 4 -2.1996
ADGRG3 adhesion G protein-coupled receptor G3 -2.1975
KLK6 kallikrein-related peptidase 6 -2.1928
TM6SF1 transmembrane 6 superfamily member 1 -2.1891
SYBU syntabulin (syntaxin-interacting) -2.187
TENT5C terminal nucleotidyltransferase 5C -2.1854
ATRN attractin -2.18325
SYK spleen tyrosine kinase -2.1816
KIF16B kinesin family member 16B -2.1771
CLIC5 chloride intracellular channel 5 -2.17543
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -2.1699
ADAT1 adenosine deaminase, tRNA-specific 1 -2.1692
TOE1 target of EGR1, member 1 (nuclear) -2.1634
MUC16 mucin 16, cell surface associated -2.1627
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -2.1544
PSME3IP1 proteasome activator subunit 3 interacting protein 1 -2.153
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 -2.1455
ZNF559-ZNF177 ZNF559-ZNF177 readthrough -2.1425
NASP nuclear autoantigenic sperm protein (histone-binding) -2.14075
POGLUT1 protein O-glucosyltransferase 1 -2.1407
SPACA9 sperm acrosome associated 9 -2.1367
TTC9 tetratricopeptide repeat domain 9 -2.1321
CIDEB cell death-inducing DFFA-like effector b -2.1266
VSIG4 V-set and immunoglobulin domain containing 4 -2.126
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 -2.1252
FPR1 formyl peptide receptor 1 -2.1194
CNKSR3 CNKSR family member 3 -2.1137
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 -2.1116
ACAA2 acetyl-CoA acyltransferase 2 -2.10955
F8 coagulation factor VIII, procoagulant component -2.1023
SPATA7 spermatogenesis associated 7 -2.0988
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 -2.0967
DDB2 damage-specific DNA binding protein 2, 48kDa -2.0958
BORCS8 BLOC-1 related complex subunit 8 -2.0935
MARCO macrophage receptor with collagenous structure -2.0899
GNG5 guanine nucleotide binding protein (G protein), gamma 5 -2.0889
FKBP1A FK506 binding protein 1A, 12kDa -2.0875
STMN1 stathmin 1 -2.0862
MRPL34 mitochondrial ribosomal protein L34 -2.0857
ANKEF1 ankyrin repeat and EF-hand domain containing 1 -2.0835
DUSP14 dual specificity phosphatase 14 -2.0816
ZNF32 zinc finger protein 32 -2.0815
HMGB2 high mobility group box 2 -2.0813
GMEB2 glucocorticoid modulatory element binding protein 2 -2.07385
GLB1L galactosidase, beta 1-like -2.0718
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) -2.0693
FKBP1C FK506 binding protein 1C -2.06825
NEFM neurofilament, medium polypeptide -2.068
ARC activity-regulated cytoskeleton-associated protein -2.0674
MTX1 metaxin 1 -2.0643
SIPA1 signal-induced proliferation-associated 1 -2.0596
LGALS4 lectin, galactoside-binding, soluble, 4 -2.0562
ARHGAP26 Rho GTPase activating protein 26 -2.05487
KRT4 keratin 4, type II -2.0538
DZANK1 double zinc ribbon and ankyrin repeat domains 1 -2.0484
EPYC epiphycan -2.0465
TLR7 toll-like receptor 7 -2.0462
AQP1 aquaporin 1 (Colton blood group) -2.04505
GMDS GDP-mannose 4,6-dehydratase -2.042
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 -2.0398
GADD45B growth arrest and DNA-damage-inducible, beta -2.03873
SF3A3 splicing factor 3a, subunit 3, 60kDa -2.0367
ZNF232 zinc finger protein 232 -2.0356
KATNB1 katanin p80 (WD repeat containing) subunit B 1 -2.03505
CTSW cathepsin W -2.0322
ZNF16 zinc finger protein 16 -2.0289
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 -2.02848
TASP1 taspase, threonine aspartase, 1 -2.028
CDADC1 cytidine and dCMP deaminase domain containing 1 -2.0279
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 -2.0275
DENND3 DENN/MADD domain containing 3 -2.0257
GPR65 G protein-coupled receptor 65 -2.0248
NRBF2 nuclear receptor binding factor 2 -2.0188
JUND jun D proto-oncogene -2.0183
CERT1 ceramide transporter 1 -2.0179
UBTF upstream binding transcription factor, RNA polymerase I -2.01745
ZC3H3 zinc finger CCCH-type containing 3 -2.0113
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -2.0029