CRCGN015_MCF10A.TP53.M_24H:P12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description megestrol 11.07 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

95 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:P12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PLS1 plastin 1 6.0553
ACAA1 acetyl-CoA acyltransferase 1 3.59277
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial 3.58495
IL1B interleukin 1, beta 3.48408
CLNS1A chloride channel, nucleotide-sensitive, 1A 3.45135
THAP12 THAP domain containing 12 3.2137
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 3.1931
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 3.07005
CENPE centromere protein E, 312kDa 3.04085
KLHL9 kelch-like family member 9 2.9856
IER3 immediate early response 3 2.8957
FHL2 four and a half LIM domains 2 2.8616
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.7633
GET1 guided entry of tail-anchored proteins factor 1 2.74125
OLFML2B olfactomedin-like 2B 2.6643
MAST2 microtubule associated serine/threonine kinase 2 2.6544
DHCR7 7-dehydrocholesterol reductase 2.5994
ALG8 ALG8, alpha-1,3-glucosyltransferase 2.40725
C2CD2 C2 calcium-dependent domain containing 2 2.32705
EVL Enah/Vasp-like 2.326
CTSV cathepsin V 2.29095
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 2.21865
MEMO1 mediator of cell motility 1 2.2071
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 2.1784
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.1556
GLIPR1 GLI pathogenesis-related 1 2.15265
SYNGAP1 synaptic Ras GTPase activating protein 1 2.14628
LIPG lipase, endothelial 2.1067
PCNA proliferating cell nuclear antigen 2.0957
AAMDC adipogenesis associated, Mth938 domain containing 2.0846
FRMD4B FERM domain containing 4B 2.08405
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 2.07225
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.06813
KIF20A kinesin family member 20A 2.0602
MALT1 MALT1 paracaspase 2.03078
KLHL21 kelch-like family member 21 2.01725

decreased expression

Symbol Name Standardized Value
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -5.48885
TRAPPC3 trafficking protein particle complex 3 -4.47175
KIF14 kinesin family member 14 -4.3062
ACOT9 acyl-CoA thioesterase 9 -4.3013
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.1209
NGRN neugrin, neurite outgrowth associated -3.41945
TBCB tubulin folding cofactor B -3.23752
MRPS15 mitochondrial ribosomal protein S15 -3.17075
PSENEN presenilin enhancer gamma secretase subunit -3.1641
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -3.04175
ADRB2 adrenoceptor beta 2, surface -2.8152
STXBP2 syntaxin binding protein 2 -2.71635
TMEM35B transmembrane protein 35B -2.69112
PRR15L proline rich 15-like -2.66885
RGS2 regulator of G-protein signaling 2 -2.61945
ZNF345 zinc finger protein 345 -2.61625
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa -2.59285
SF3A3 splicing factor 3a, subunit 3, 60kDa -2.4925
TCEAL4 transcription elongation factor A (SII)-like 4 -2.49185
TRIM39-RPP21 TRIM39-RPP21 readthrough -2.4844
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -2.4149
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) -2.37378
POLR2J3 polymerase (RNA) II (DNA directed) polypeptide J3 -2.35897
MRPS11 mitochondrial ribosomal protein S11 -2.34083
ZNF768 zinc finger protein 768 -2.3128
LIN37 lin-37 DREAM MuvB core complex component -2.30535
TSC22D3 TSC22 domain family, member 3 -2.30535
ZNF146 zinc finger protein 146 -2.3001
PDCD5 programmed cell death 5 -2.29325
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative) -2.2723
NR3C2 nuclear receptor subfamily 3, group C, member 2 -2.23915
VTI1B vesicle transport through interaction with t-SNAREs 1B -2.2375
MMP23B matrix metallopeptidase 23B -2.22945
SPIN2B spindlin family, member 2B -2.22535
FLT4 fms-related tyrosine kinase 4 -2.205
ZNF76 zinc finger protein 76 -2.18655
ZMYM4 zinc finger, MYM-type 4 -2.18307
H2BC3 H2B clustered histone 3 -2.17485
TMEM147 transmembrane protein 147 -2.16945
DCTN1 dynactin 1 -2.14515
MRPL46 mitochondrial ribosomal protein L46 -2.11425
QTRT1 queuine tRNA-ribosyltransferase 1 -2.10875
UPK1A uroplakin 1A -2.0891
RNF146 ring finger protein 146 -2.08465
PENK proenkephalin -2.07735
CD2BP2 CD2 (cytoplasmic tail) binding protein 2 -2.07718
GPKOW G patch domain and KOW motifs -2.07365
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 -2.06455
LOC102724594 splicing factor U2AF 35 kDa subunit -2.06045
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial -2.0553
RNF2 ring finger protein 2 -2.04425
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.04287
CAMTA1 calmodulin binding transcription activator 1 -2.0427
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 -2.04005
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 -2.02995
MAP7D3 MAP7 domain containing 3 -2.01765
ZKSCAN3 zinc finger with KRAB and SCAN domains 3 -2.0066
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa -2.00472
SLC68A1 solute carrier family 68 member 1 -2.0014