CRCGN015_MCF10A.TP53.M_24H:P14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description uracil mustard 33.81 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

547 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:P14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 7.6719
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 7.4039
TCEA2 transcription elongation factor A (SII), 2 6.86055
CNRIP1 cannabinoid receptor interacting protein 1 6.77425
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 6.4193
CAPN1 calpain 1, (mu/I) large subunit 5.57475
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 5.22915
TICAM1 toll-like receptor adaptor molecule 1 4.8938
KCTD5 potassium channel tetramerization domain containing 5 4.8869
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.6967
MINDY1 MINDY lysine 48 deubiquitinase 1 4.3929
PAQR4 progestin and adipoQ receptor family member IV 4.26345
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.0809
VGLL4 vestigial-like family member 4 3.92772
NUCB2 nucleobindin 2 3.8672
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 3.85235
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.84795
CDC45 cell division cycle 45 3.82835
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 3.803
LRP10 low density lipoprotein receptor-related protein 10 3.7689
ERN2 endoplasmic reticulum to nucleus signaling 2 3.7161
HSPB1 heat shock 27kDa protein 1 3.5484
UBE2L6 ubiquitin-conjugating enzyme E2L 6 3.5129
STXBP1 syntaxin binding protein 1 3.45885
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 3.29355
TUBB6 tubulin, beta 6 class V 3.2714
MUC1 mucin 1, cell surface associated 3.26423
ABHD4 abhydrolase domain containing 4 3.25175
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.22965
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) 3.19147
PTPN6 protein tyrosine phosphatase, non-receptor type 6 3.1846
MVP major vault protein 3.17055
SAMD14 sterile alpha motif domain containing 14 3.16165
DGKA diacylglycerol kinase, alpha 80kDa 3.15612
KCTD9 potassium channel tetramerization domain containing 9 3.126
CYB5R1 cytochrome b5 reductase 1 3.125
S100A4 S100 calcium binding protein A4 3.0875
SAMD9 sterile alpha motif domain containing 9 3.0672
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 2.97915
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 2.97235
DTX2 deltex 2, E3 ubiquitin ligase 2.96675
HMOX1 heme oxygenase 1 2.9652
SFI1 Sfi1 homolog, spindle assembly associated (yeast) 2.93971
TNIP1 TNFAIP3 interacting protein 1 2.92995
SMIM40 small integral membrane protein 40 2.8702
FZD1 frizzled class receptor 1 2.85885
EPHA2 EPH receptor A2 2.8446
ETHE1 ethylmalonic encephalopathy 1 2.8443
BCL7C B-cell CLL/lymphoma 7C 2.8188
ACBD3 acyl-CoA binding domain containing 3 2.81085
IFI6 interferon, alpha-inducible protein 6 2.8009
MYO1E myosin IE 2.79582
GINS4 GINS complex subunit 4 (Sld5 homolog) 2.7938
BRCA1 breast cancer 1, early onset 2.7748
ALS2CL ALS2 C-terminal like 2.767
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.75095
SPRR1B small proline-rich protein 1B 2.716
GMIP GEM interacting protein 2.71545
FSTL1 follistatin-like 1 2.71255
CLDN7 claudin 7 2.7091
POLE polymerase (DNA directed), epsilon, catalytic subunit 2.70645
PXMP2 peroxisomal membrane protein 2, 22kDa 2.69935
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 2.6951
CDPF1 cysteine-rich, DPF motif domain containing 1 2.6883
STX4 syntaxin 4 2.68815
STMN1 stathmin 1 2.68005
TP53BP2 tumor protein p53 binding protein 2 2.66625
PARD6A par-6 family cell polarity regulator alpha 2.6659
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.66125
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 2.65855
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.6535
APH1A APH1A gamma secretase subunit 2.6506
ACAD10 acyl-CoA dehydrogenase family, member 10 2.64545
DSCC1 DNA replication and sister chromatid cohesion 1 2.6433
GRAMD2B GRAM domain containing 2B 2.63795
POLR2J3 polymerase (RNA) II (DNA directed) polypeptide J3 2.62825
SPRING1 SREBF pathway regulator in golgi 1 2.62595
TRAK2 trafficking protein, kinesin binding 2 2.61153
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.6065
TMPRSS5 transmembrane protease, serine 5 2.6024
TSPAN6 tetraspanin 6 2.59053
INPP1 inositol polyphosphate-1-phosphatase 2.58815
CCND3 cyclin D3 2.58035
SPRR2B small proline-rich protein 2B 2.57745
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.57745
ESYT1 extended synaptotagmin-like protein 1 2.557
BIK BCL2-interacting killer (apoptosis-inducing) 2.5549
ATRIP ATR interacting protein 2.55333
PRR15L proline rich 15-like 2.53625
INTS3 integrator complex subunit 3 2.53535
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 2.53525
HSPB11 heat shock protein family B (small), member 11 2.52553
EPS8L2 EPS8-like 2 2.523
GNL1 guanine nucleotide binding protein-like 1 2.51065
PODNL1 podocan-like 1 2.50665
PYCARD PYD and CARD domain containing 2.5048
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 2.50395
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 2.50235
TCEAL9 transcription elongation factor A like 9 2.47975
STAP2 signal transducing adaptor family member 2 2.47085
MPC2 mitochondrial pyruvate carrier 2 2.4702
KRT16 keratin 16, type I 2.4695
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.4693
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 2.46335
HACL2 2-hydroxyacyl-CoA lyase 2 2.455
CLIC3 chloride intracellular channel 3 2.44975
CMTR1 cap methyltransferase 1 2.4421
TMEM132A transmembrane protein 132A 2.43655
CARD14 caspase recruitment domain family, member 14 2.4311
NAA40 N(alpha)-acetyltransferase 40, NatD catalytic subunit 2.42753
FCHO1 FCH domain only 1 2.4259
EPHX3 epoxide hydrolase 3 2.4237
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 2.4227
EFNA3 ephrin-A3 2.421
ZIC1 Zic family member 1 2.4188
CCNE1 cyclin E1 2.41735
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein 2.41229
DEF6 differentially expressed in FDCP 6 homolog (mouse) 2.41215
CNN2 calponin 2 2.40895
KREMEN2 kringle containing transmembrane protein 2 2.40275
KRT24 keratin 24, type I 2.40205
RFC2 replication factor C (activator 1) 2, 40kDa 2.39295
IFI35 interferon-induced protein 35 2.3914
MCM5 minichromosome maintenance complex component 5 2.39003
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 2.3889
SLC35E1 solute carrier family 35, member E1 2.3888
CENPM centromere protein M 2.38215
HDAC1 histone deacetylase 1 2.37365
UBA7 ubiquitin-like modifier activating enzyme 7 2.3653
HAT1 histone acetyltransferase 1 2.3648
MUC13 mucin 13, cell surface associated 2.36345
RAB4B RAB4B, member RAS oncogene family 2.35315
IRF6 interferon regulatory factor 6 2.3527
GNG3 guanine nucleotide binding protein (G protein), gamma 3 2.34615
TP53I3 tumor protein p53 inducible protein 3 2.3459
NIT1 nitrilase 1 2.34475
ECM1 extracellular matrix protein 1 2.34055
STX12 syntaxin 12 2.33752
SPRR1A small proline-rich protein 1A 2.33602
PPME1 protein phosphatase methylesterase 1 2.33332
CNPY3 canopy FGF signaling regulator 3 2.32685
PIGR polymeric immunoglobulin receptor 2.3247
PPP2R5B protein phosphatase 2, regulatory subunit B', beta 2.3235
CDC25A cell division cycle 25A 2.31778
RHCG Rh family, C glycoprotein 2.3168
PI3 peptidase inhibitor 3, skin-derived 2.30988
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5 2.30975
TRIM45 tripartite motif containing 45 2.29235
GLTP glycolipid transfer protein 2.29175
IL17RA interleukin 17 receptor A 2.2833
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.27905
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 2.2739
RIOK3 RIO kinase 3 2.27372
TM7SF2 transmembrane 7 superfamily member 2 2.2711
CD79B CD79b molecule, immunoglobulin-associated beta 2.26965
LGALS9C lectin, galactoside-binding, soluble, 9C 2.26875
PPL periplakin 2.26595
KLF4 Kruppel-like factor 4 (gut) 2.26195
TOPBP1 topoisomerase (DNA) II binding protein 1 2.2613
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 2.25945
SAA4 serum amyloid A4, constitutive 2.2555
ANXA11 annexin A11 2.25478
OSBPL2 oxysterol binding protein-like 2 2.25338
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle 2.24915
DLK2 delta-like 2 homolog (Drosophila) 2.24805
BID BH3 interacting domain death agonist 2.24643
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 2.24035
ADRA2B adrenoceptor alpha 2B 2.2374
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 2.2343
METTL17 methyltransferase like 17 2.23335
TUFT1 tuftelin 1 2.2332
LYPD3 LY6/PLAUR domain containing 3 2.22905
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 2.2235
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 2.2222
RGS2 regulator of G-protein signaling 2 2.2171
DHRS1 dehydrogenase/reductase (SDR family) member 1 2.2126
MMP15 matrix metallopeptidase 15 (membrane-inserted) 2.2099
E2F1 E2F transcription factor 1 2.20878
OCA2 oculocutaneous albinism II 2.2084
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa 2.20035
DCTPP1 dCTP pyrophosphatase 1 2.1996
ZDHHC6 zinc finger, DHHC-type containing 6 2.1996
ANXA4 annexin A4 2.189
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 2.1861
OASL 2'-5'-oligoadenylate synthetase-like 2.1843
ASF1B anti-silencing function 1B histone chaperone 2.17635
INPPL1 inositol polyphosphate phosphatase-like 1 2.17565
INF2 inverted formin, FH2 and WH2 domain containing 2.17265
DDA1 DET1 and DDB1 associated 1 2.17065
IVL involucrin 2.1704
NBEAL2 neurobeachin-like 2 2.16195
AMDHD2 amidohydrolase domain containing 2 2.1571
CDK5 cyclin-dependent kinase 5 2.153
TBC1D31 TBC1 domain family, member 31 2.1526
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) 2.14935
STIL SCL/TAL1 interrupting locus 2.1492
EPHA1 EPH receptor A1 2.13815
TEDC2 tubulin epsilon and delta complex 2 2.13335
TAOK1 TAO kinase 1 2.1328
MST1R macrophage stimulating 1 receptor 2.12805
SIPA1 signal-induced proliferation-associated 1 2.125
CEP131 centrosomal protein 131kDa 2.1214
PSMC3IP PSMC3 interacting protein 2.11995
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 2.11792
BST2 bone marrow stromal cell antigen 2 2.1164
EMP1 epithelial membrane protein 1 2.1158
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) 2.11525
TSPAN1 tetraspanin 1 2.1138
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 2.1127
KRT6A keratin 6A, type II 2.11265
CARHSP1 calcium regulated heat stable protein 1, 24kDa 2.11245
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) 2.1104
LDHD lactate dehydrogenase D 2.1077
TMEM40 transmembrane protein 40 2.10715
CCNE2 cyclin E2 2.10537
RNF125 ring finger protein 125, E3 ubiquitin protein ligase 2.10435
MAB21L1 mab-21-like 1 (C. elegans) 2.103
ABHD11 abhydrolase domain containing 11 2.10295
IRF9 interferon regulatory factor 9 2.10125
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2.09812
NUTF2 nuclear transport factor 2 2.09715
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 2.09525
CHAF1A chromatin assembly factor 1, subunit A (p150) 2.0951
BIRC7 baculoviral IAP repeat containing 7 2.09335
ZWINT ZW10 interacting kinetochore protein 2.09275
INAVA innate immunity activator 2.09195
IL3RA interleukin 3 receptor, alpha (low affinity) 2.08755
CDC37 cell division cycle 37 2.08735
TTLL3 tubulin tyrosine ligase-like family member 3 2.08445
PTPRS protein tyrosine phosphatase, receptor type, S 2.08335
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific 2.08185
ADAM15 ADAM metallopeptidase domain 15 2.07655
DDR2 discoidin domain receptor tyrosine kinase 2 2.07325
DGKD diacylglycerol kinase, delta 130kDa 2.0732
PDGFD platelet derived growth factor D 2.07145
MRNIP MRN complex interacting protein 2.0713
PRR3 proline rich 3 2.07075
PSENEN presenilin enhancer gamma secretase subunit 2.0691
NYNRIN NYN domain and retroviral integrase containing 2.0673
ANKZF1 ankyrin repeat and zinc finger domain containing 1 2.05775
ISG15 ISG15 ubiquitin-like modifier 2.0567
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon 2.0559
KRT4 keratin 4, type II 2.0546
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 2.04985
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2.0488
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 2.04625
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 2.04595
SEC14L2 SEC14-like 2 (S. cerevisiae) 2.0424
SYT17 synaptotagmin XVII 2.0408
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 2.04065
GINS2 GINS complex subunit 2 (Psf2 homolog) 2.04065
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2.0405
SH2D4A SH2 domain containing 4A 2.036
ZNF821 zinc finger protein 821 2.0358
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 2.0343
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6 2.0319
TIMP2 TIMP metallopeptidase inhibitor 2 2.03135
CKMT1A creatine kinase, mitochondrial 1A 2.03085
ZNF611 zinc finger protein 611 2.0293
TMEM59 transmembrane protein 59 2.02905
MTA2 metastasis associated 1 family, member 2 2.02855
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.02793
PGPEP1 pyroglutamyl-peptidase I 2.02725
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 2.026
MX1 MX dynamin-like GTPase 1 2.02405
PANK2 pantothenate kinase 2 2.0238
SHARPIN SHANK-associated RH domain interactor 2.02345
AMOTL2 angiomotin like 2 2.0206
SECTM1 secreted and transmembrane 1 2.0195
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 2.0178
SH3GLB2 SH3-domain GRB2-like endophilin B2 2.01285
GSDMB gasdermin B 2.00625
KRT13 keratin 13, type I 2.00315
PMP22 peripheral myelin protein 22 2.00161
LTB lymphotoxin beta (TNF superfamily, member 3) 2.00155
WDR76 WD repeat domain 76 2.0012
PRB3 proline-rich protein BstNI subfamily 3 2.00025

decreased expression

Symbol Name Standardized Value
KIF20A kinesin family member 20A -9.3448
CCNB2 cyclin B2 -8.13915
CDC20 cell division cycle 20 -6.32365
PLK1 polo-like kinase 1 -6.07315
MRPS2 mitochondrial ribosomal protein S2 -6.03855
TOP2A topoisomerase (DNA) II alpha 170kDa -5.9272
ANKRD10 ankyrin repeat domain 10 -5.92655
MTERF3 mitochondrial transcription termination factor 3 -5.75745
HSPA1A heat shock 70kDa protein 1A -5.22555
KIF14 kinesin family member 14 -5.2028
UBE2C ubiquitin-conjugating enzyme E2C -4.7783
CENPA centromere protein A -4.6103
PSRC1 proline/serine-rich coiled-coil 1 -4.58555
GRWD1 glutamate-rich WD repeat containing 1 -4.51565
AURKA aurora kinase A -4.25243
MYC v-myc avian myelocytomatosis viral oncogene homolog -4.2331
CCNA2 cyclin A2 -4.0628
DEPDC1 DEP domain containing 1 -4.03765
HMMR hyaluronan-mediated motility receptor (RHAMM) -4.017
TBPL1 TBP-like 1 -3.9554
BASP1 brain abundant, membrane attached signal protein 1 -3.8209
CCNB1 cyclin B1 -3.70385
DDIT4 DNA-damage-inducible transcript 4 -3.6633
RUVBL1 RuvB-like AAA ATPase 1 -3.6248
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.606
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -3.6012
ENTR1 endosome associated trafficking regulator 1 -3.47815
PALS2 protein associated with LIN7 2, MAGUK p55 family member -3.4402
DET1 de-etiolated homolog 1 (Arabidopsis) -3.425
CDKN3 cyclin-dependent kinase inhibitor 3 -3.3993
INTS15 integrator complex subunit 15 -3.39307
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 -3.3504
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -3.2666
SEC16A SEC16 homolog A (S. cerevisiae) -3.25655
NOP16 NOP16 nucleolar protein -3.2382
CDCA3 cell division cycle associated 3 -3.21875
LBR lamin B receptor -3.18685
MED27 mediator complex subunit 27 -3.18012
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -3.13495
PRC1 protein regulator of cytokinesis 1 -3.13365
MYO5A myosin VA (heavy chain 12, myoxin) -3.13045
RPA3 replication protein A3, 14kDa -3.12765
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 -3.11575
TCERG1 transcription elongation regulator 1 -3.11385
HDAC2 histone deacetylase 2 -3.0967
PARVB parvin, beta -3.09105
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.07373
KIF4A kinesin family member 4A -3.0699
NPR2 natriuretic peptide receptor 2 -3.0473
MRFAP1L1 Morf4 family associated protein 1-like 1 -3.0256
SQSTM1 sequestosome 1 -2.99785
BIRC5 baculoviral IAP repeat containing 5 -2.99565
PIMREG PICALM interacting mitotic regulator -2.99465
RPP40 ribonuclease P/MRP 40kDa subunit -2.9708
COQ3 coenzyme Q3 methyltransferase -2.95835
BOLA1 bolA family member 1 -2.95745
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa -2.94735
MLH3 mutL homolog 3 -2.94133
TMEM185B transmembrane protein 185B -2.92985
LIPT1 lipoyltransferase 1 -2.916
FBXO5 F-box protein 5 -2.88385
PBK PDZ binding kinase -2.8747
ILK integrin-linked kinase -2.86245
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.8512
CCT7 chaperonin containing TCP1, subunit 7 (eta) -2.84005
SURF2 surfeit 2 -2.8151
ASCC3 activating signal cointegrator 1 complex subunit 3 -2.81185
RHOT1 ras homolog family member T1 -2.77052
TXNRD3 thioredoxin reductase 3 -2.76717
EIF3B eukaryotic translation initiation factor 3, subunit B -2.76473
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.76265
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) -2.7606
TACC3 transforming, acidic coiled-coil containing protein 3 -2.7107
PAEP progestagen-associated endometrial protein -2.7041
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -2.70245
THOC7 THO complex 7 -2.6978
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3 -2.69775
SUMF2 sulfatase modifying factor 2 -2.6839
UNC13B unc-13 homolog B (C. elegans) -2.6782
MRPL12 mitochondrial ribosomal protein L12 -2.6719
NGRN neugrin, neurite outgrowth associated -2.6699
DDN dendrin -2.6664
EGR1 early growth response 1 -2.65405
PMPCA peptidase (mitochondrial processing) alpha -2.65075
CR2 complement component (3d/Epstein Barr virus) receptor 2 -2.64455
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.63295
FJX1 four jointed box 1 (Drosophila) -2.63225
CEBPD CCAAT/enhancer binding protein (C/EBP), delta -2.62985
RNF38 ring finger protein 38 -2.6245
RBPJ recombination signal binding protein for immunoglobulin kappa J region -2.62287
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) -2.61645
MRS2 MRS2 magnesium transporter -2.6109
CDC25B cell division cycle 25B -2.6108
CDCA8 cell division cycle associated 8 -2.58945
MAPKAP1 mitogen-activated protein kinase associated protein 1 -2.58675
MAEA macrophage erythroblast attacher -2.5854
CYCS cytochrome c, somatic -2.57455
DPH2 DPH2 homolog (S. cerevisiae) -2.5736
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) -2.5712
MRPL3 mitochondrial ribosomal protein L3 -2.5712
EBNA1BP2 EBNA1 binding protein 2 -2.56715
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) -2.56445
OTUD4 OTU deubiquitinase 4 -2.5597
DCTD dCMP deaminase -2.55935
CADPS2 Ca++-dependent secretion activator 2 -2.5552
ISOC1 isochorismatase domain containing 1 -2.54465
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 -2.5412
PRMT3 protein arginine methyltransferase 3 -2.54085
MEMO1 mediator of cell motility 1 -2.5366
C1QBP complement component 1, q subcomponent binding protein -2.52135
PAK1IP1 PAK1 interacting protein 1 -2.51565
UIMC1 ubiquitin interaction motif containing 1 -2.5137
RXYLT1 ribitol xylosyltransferase 1 -2.50903
GEMIN6 gem (nuclear organelle) associated protein 6 -2.5004
GARRE1 granule associated Rac and RHOG effector 1 -2.4979
RPIA ribose 5-phosphate isomerase A -2.4963
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32 -2.4913
HSPD1 heat shock 60kDa protein 1 (chaperonin) -2.47635
DOLK dolichol kinase -2.47255
NPM3 nucleophosmin/nucleoplasmin 3 -2.4672
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites -2.4559
MRPL19 mitochondrial ribosomal protein L19 -2.45295
WASF3 WAS protein family, member 3 -2.44695
UBAC1 UBA domain containing 1 -2.4414
TWNK twinkle mtDNA helicase -2.44025
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -2.4402
SKA1 spindle and kinetochore associated complex subunit 1 -2.43725
PYCR1 pyrroline-5-carboxylate reductase 1 -2.42285
UBE2S ubiquitin-conjugating enzyme E2S -2.4117
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -2.4069
NAXD NAD(P)HX dehydratase -2.4063
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 -2.40475
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor -2.39995
INTS8 integrator complex subunit 8 -2.3985
ATG3 autophagy related 3 -2.39353
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 -2.38785
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) -2.38725
NCAPD2 non-SMC condensin I complex, subunit D2 -2.38255
EXOSC5 exosome component 5 -2.3804
LIAS lipoic acid synthetase -2.3787
GCA grancalcin, EF-hand calcium binding protein -2.37575
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) -2.37525
PCBP1 poly(rC) binding protein 1 -2.372
MRPL58 mitochondrial ribosomal protein L58 -2.37185
GNPDA1 glucosamine-6-phosphate deaminase 1 -2.371
CPM carboxypeptidase M -2.36365
APRT adenine phosphoribosyltransferase -2.36048
TRMT61B tRNA methyltransferase 61B -2.34815
NEK2 NIMA-related kinase 2 -2.3455
STOML2 stomatin (EPB72)-like 2 -2.3433
BRD3 bromodomain containing 3 -2.33707
ZNF516 zinc finger protein 516 -2.3318
ACOD1 aconitate decarboxylase 1 -2.32975
TREM1 triggering receptor expressed on myeloid cells 1 -2.3061
RPAP1 RNA polymerase II associated protein 1 -2.30555
GPHN gephyrin -2.3042
RIOX2 ribosomal oxygenase 2 -2.3027
LAMC1 laminin, gamma 1 (formerly LAMB2) -2.29903
COMMD10 COMM domain containing 10 -2.2978
COPS7A COP9 signalosome subunit 7A -2.29245
TKT transketolase -2.28655
RANBP6 RAN binding protein 6 -2.284
NAP1L2 nucleosome assembly protein 1-like 2 -2.2793
RESF1 retroelement silencing factor 1 -2.2762
PARP1 poly (ADP-ribose) polymerase 1 -2.2754
DBF4 DBF4 zinc finger -2.2727
CEP63 centrosomal protein 63kDa -2.27198
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 -2.2701
GYG1 glycogenin 1 -2.26935
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa -2.25657
ALG3 ALG3, alpha-1,3- mannosyltransferase -2.2559
TPX2 TPX2, microtubule-associated -2.2559
ZNF593 zinc finger protein 593 -2.2515
CETN3 centrin, EF-hand protein, 3 -2.25115
ATG9A autophagy related 9A -2.2493
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa -2.24925
TRIM27 tripartite motif containing 27 -2.2443
HSPA8 heat shock 70kDa protein 8 -2.2427
SLC35F2 solute carrier family 35, member F2 -2.2377
NT5DC2 5'-nucleotidase domain containing 2 -2.23255
ZNF354A zinc finger protein 354A -2.22145
SPC25 SPC25, NDC80 kinetochore complex component -2.21515
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -2.2131
RSAD1 radical S-adenosyl methionine domain containing 1 -2.2058
SAYSD1 SAYSVFN motif domain containing 1 -2.1984
MNDA myeloid cell nuclear differentiation antigen -2.1976
ZNF571 zinc finger protein 571 -2.19585
PARPBP PARP1 binding protein -2.18805
SGPP1 sphingosine-1-phosphate phosphatase 1 -2.18705
ZKSCAN2 zinc finger with KRAB and SCAN domains 2 -2.1821
NOP14 NOP14 nucleolar protein -2.1795
NELFA negative elongation factor complex member A -2.17782
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -2.17665
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 -2.1745
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 -2.17375
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.16645
FCN1 ficolin (collagen/fibrinogen domain containing) 1 -2.15275
NAT10 N-acetyltransferase 10 (GCN5-related) -2.1509
CENPF centromere protein F, 350/400kDa -2.14908
BCL2A1 BCL2-related protein A1 -2.1415
CCT3 chaperonin containing TCP1, subunit 3 (gamma) -2.13935
GRPEL1 GrpE-like 1, mitochondrial (E. coli) -2.1383
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) -2.1362
KIAA0586 KIAA0586 -2.136
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa -2.1343
GARS1 glycyl-tRNA synthetase 1 -2.13355
RHOB ras homolog family member B -2.13035
MPHOSPH6 M-phase phosphoprotein 6 -2.12995
CCDC102B coiled-coil domain containing 102B -2.1291
TRIM37 tripartite motif containing 37 -2.1282
HNRNPM heterogeneous nuclear ribonucleoprotein M -2.12705
HEATR3 HEAT repeat containing 3 -2.1235
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.12185
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -2.12155
ZNF165 zinc finger protein 165 -2.11865
TLR1 toll-like receptor 1 -2.11665
GCFC2 GC-rich sequence DNA-binding factor 2 -2.11433
YARS1 tyrosyl-tRNA synthetase 1 -2.1118
CCT4 chaperonin containing TCP1, subunit 4 (delta) -2.11135
GTPBP6 GTP binding protein 6 (putative) -2.0939
KIF23 kinesin family member 23 -2.0895
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.0886
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 -2.08705
LRP3 low density lipoprotein receptor-related protein 3 -2.08615
ERCC6L excision repair cross-complementation group 6-like -2.0846
FXN frataxin -2.084
ZNF239 zinc finger protein 239 -2.08225
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 -2.08165
RBM12B RNA binding motif protein 12B -2.0705
TRAP1 TNF receptor-associated protein 1 -2.069
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -2.06
PEX7 peroxisomal biogenesis factor 7 -2.05962
NAE1 NEDD8 activating enzyme E1 subunit 1 -2.05735
HAPSTR1 HUWE1 associated protein modifying stress responses -2.05605
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor -2.05265
YY1AP1 YY1 associated protein 1 -2.0517
PLAG1 pleiomorphic adenoma gene 1 -2.05035
NUP93 nucleoporin 93kDa -2.0487
CDK4 cyclin-dependent kinase 4 -2.04865
PPP4R4 protein phosphatase 4, regulatory subunit 4 -2.0483
IL18RAP interleukin 18 receptor accessory protein -2.0475
APOO apolipoprotein O -2.045
MERTK MER proto-oncogene, tyrosine kinase -2.0441
NLE1 notchless homolog 1 (Drosophila) -2.04205
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B -2.04075
RIOX1 ribosomal oxygenase 1 -2.03995
NSD1 nuclear receptor binding SET domain protein 1 -2.03835
BCHE butyrylcholinesterase -2.03785
BLMH bleomycin hydrolase -2.0353
ACOT2 acyl-CoA thioesterase 2 -2.0324
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 -2.03065
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 -2.02605
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 -2.02425
INTS14 integrator complex subunit 14 -2.02295
ZNF143 zinc finger protein 143 -2.02225
VCP valosin containing protein -2.02023
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -2.0199
BPHL biphenyl hydrolase-like (serine hydrolase) -2.01875
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.01785
WRN Werner syndrome, RecQ helicase-like -2.0145
HEMK2 HemK methyltransferase 2, ETF1 glutamine and histone H4 lysine -2.0144
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.01065
NRGN neurogranin (protein kinase C substrate, RC3) -2.0097
NEIL3 nei endonuclease VIII-like 3 (E. coli) -2.00915
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa -2.0056
ZNF146 zinc finger protein 146 -2.004
CBX3 chromobox homolog 3 -2.00347
GAB2 GRB2-associated binding protein 2 -2.0012
LOC105379278 uncharacterized LOC105379278 -2.00075
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) -2.00025