CRCGN015_MCF10A.TP53.M_24H:P16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description amsonic acid 100.55 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

723 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:P16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
KIF5C kinesin family member 5C 8.0472
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 6.1287
NUCB2 nucleobindin 2 6.1133
MMP1 matrix metallopeptidase 1 5.624
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 4.6396
UBE2L6 ubiquitin-conjugating enzyme E2L 6 4.4917
LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 4.0934
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 4.0471
SYNPO synaptopodin 4.0249
SP140L SP140 nuclear body protein-like 3.939
GRB7 growth factor receptor-bound protein 7 3.8567
DPYSL3 dihydropyrimidinase-like 3 3.7903
SPDEF SAM pointed domain containing ETS transcription factor 3.71597
BAX BCL2-associated X protein 3.69275
DOCK4 dedicator of cytokinesis 4 3.6901
GBP1 guanylate binding protein 1, interferon-inducible 3.68035
ADGRL4 adhesion G protein-coupled receptor L4 3.5654
TBC1D31 TBC1 domain family, member 31 3.4724
PLVAP plasmalemma vesicle associated protein 3.4199
ECHDC3 enoyl CoA hydratase domain containing 3 3.3169
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10 3.3163
BZW2 basic leucine zipper and W2 domains 2 3.239
CCL2 chemokine (C-C motif) ligand 2 3.1791
SH2D3A SH2 domain containing 3A 3.16085
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 3.121
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 3.11395
COQ4 coenzyme Q4 3.1085
TMEM140 transmembrane protein 140 3.1058
PECR peroxisomal trans-2-enoyl-CoA reductase 3.1003
GUCY1A2 guanylate cyclase 1, soluble, alpha 2 3.0899
CUL1 cullin 1 3.0822
TRAIP TRAF interacting protein 3.0625
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 3.0417
DENND2D DENN/MADD domain containing 2D 3.0272
C1RL complement component 1, r subcomponent-like 3.0006
GIMAP4 GTPase, IMAP family member 4 2.9867
FOLR3 folate receptor 3 (gamma) 2.9866
STK16 serine/threonine kinase 16 2.9838
ADGRG6 adhesion G protein-coupled receptor G6 2.9735
LIMK2 LIM domain kinase 2 2.96547
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 2.9602
MMRN2 multimerin 2 2.9564
KLF7 Kruppel-like factor 7 (ubiquitous) 2.9519
AP1S1 adaptor-related protein complex 1, sigma 1 subunit 2.9431
E4F1 E4F transcription factor 1 2.9403
DDN dendrin 2.9225
LRP5 low density lipoprotein receptor-related protein 5 2.9194
STX4 syntaxin 4 2.9125
ANKRD6 ankyrin repeat domain 6 2.90445
PISD phosphatidylserine decarboxylase 2.9016
IQSEC3 IQ motif and Sec7 domain 3 2.8924
ZNF623 zinc finger protein 623 2.8872
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 2.8724
FGG fibrinogen gamma chain 2.8475
TMPRSS3 transmembrane protease, serine 3 2.8303
ESM1 endothelial cell-specific molecule 1 2.8181
C5AR1 complement component 5a receptor 1 2.816
AOC3 amine oxidase, copper containing 3 2.8073
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 2.8066
NSUN5 NOP2/Sun domain family, member 5 2.80195
BCKDK branched chain ketoacid dehydrogenase kinase 2.7889
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 2.7767
HSPG2 heparan sulfate proteoglycan 2 2.7526
ORAI3 ORAI calcium release-activated calcium modulator 3 2.7525
PTK6 protein tyrosine kinase 6 2.7514
SOX11 SRY (sex determining region Y)-box 11 2.74313
CNKSR1 connector enhancer of kinase suppressor of Ras 1 2.7217
ZNF696 zinc finger protein 696 2.7214
TGFB3 transforming growth factor, beta 3 2.7211
SCARF1 scavenger receptor class F, member 1 2.7204
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.7173
RAD51AP1 RAD51 associated protein 1 2.716
ARID5B AT rich interactive domain 5B (MRF1-like) 2.7157
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) 2.7131
AURKB aurora kinase B 2.7084
AQP9 aquaporin 9 2.6915
LOC124900275 extensin-like 2.6878
GSDMB gasdermin B 2.6761
JUP junction plakoglobin 2.6685
HPGDS hematopoietic prostaglandin D synthase 2.667
OIP5 Opa interacting protein 5 2.6646
GIMAP6 GTPase, IMAP family member 6 2.6629
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 2.6602
AOPEP aminopeptidase O (putative) 2.6579
PLEKHO1 pleckstrin homology domain containing, family O member 1 2.6455
KITLG KIT ligand 2.64365
F5 coagulation factor V (proaccelerin, labile factor) 2.6418
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 2.6372
S100A1 S100 calcium binding protein A1 2.6343
TKTL1 transketolase-like 1 2.63385
ACTG2 actin, gamma 2, smooth muscle, enteric 2.6313
WDR33 WD repeat domain 33 2.6309
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 2.60845
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 2.6017
ZNF7 zinc finger protein 7 2.6001
JCAD junctional cadherin 5 associated 2.5901
ACP5 acid phosphatase 5, tartrate resistant 2.5888
MMP10 matrix metallopeptidase 10 2.5821
CRABP2 cellular retinoic acid binding protein 2 2.5752
PCDH17 protocadherin 17 2.5727
RIGI RNA sensor RIG-I 2.5723
FANCF Fanconi anemia, complementation group F 2.5716
ZNF273 zinc finger protein 273 2.5713
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 2.56603
RTN2 reticulon 2 2.5647
MSR1 macrophage scavenger receptor 1 2.56425
FST follistatin 2.56385
ST20-MTHFS ST20-MTHFS readthrough 2.5632
CLEC5A C-type lectin domain family 5, member A 2.5493
CXADR coxsackie virus and adenovirus receptor 2.5472
MMP8 matrix metallopeptidase 8 2.5455
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 2.53217
IFT70A intraflagellar transport 70A 2.5317
CA3 carbonic anhydrase III 2.5298
CD101 CD101 molecule 2.5242
MORC3 MORC family CW-type zinc finger 3 2.5202
VAV1 vav 1 guanine nucleotide exchange factor 2.5187
PATJ PATJ crumbs cell polarity complex component 2.5171
ZNF764 zinc finger protein 764 2.5163
LRRC17 leucine rich repeat containing 17 2.4986
ALPK1 alpha-kinase 1 2.4973
CD93 CD93 molecule 2.496
MTAP methylthioadenosine phosphorylase 2.4956
S1PR1 sphingosine-1-phosphate receptor 1 2.4953
PXDN peroxidasin 2.49468
PARP16 poly (ADP-ribose) polymerase family, member 16 2.4935
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 2.492
FLT1 fms-related tyrosine kinase 1 2.49005
SMAD3 SMAD family member 3 2.48805
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1 2.4827
WDR73 WD repeat domain 73 2.4731
FABP4 fatty acid binding protein 4, adipocyte 2.4725
CFHR2 complement factor H-related 2 2.4626
VRK2 vaccinia related kinase 2 2.4566
ELAC1 elaC ribonuclease Z 1 2.4457
ANGPT2 angiopoietin 2 2.4456
RASL12 RAS-like, family 12 2.4455
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific 2.4448
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial) 2.4431
BRIX1 BRX1, biogenesis of ribosomes 2.4413
GALP galanin-like peptide 2.4391
NKIRAS2 NFKB inhibitor interacting Ras-like 2 2.4385
DNALI1 dynein, axonemal, light intermediate chain 1 2.4385
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) 2.4337
VILL villin-like 2.4337
EGFL6 EGF-like-domain, multiple 6 2.4318
SPTLC3 serine palmitoyltransferase, long chain base subunit 3 2.4293
EPHB6 EPH receptor B6 2.4257
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 2.4252
CDK17 cyclin-dependent kinase 17 2.42175
RAI14 retinoic acid induced 14 2.4195
HOOK1 hook microtubule-tethering protein 1 2.4181
IFRD1 interferon-related developmental regulator 1 2.40915
NOX4 NADPH oxidase 4 2.4083
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 2.4049
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.4048
NIT1 nitrilase 1 2.3999
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 2.3997
TRAPPC6A trafficking protein particle complex 6A 2.3991
FBXL6 F-box and leucine-rich repeat protein 6 2.397
CCDC102B coiled-coil domain containing 102B 2.3956
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.39543
ADGRE3 adhesion G protein-coupled receptor E3 2.3951
CIRSR corepressor of RBPJ and splicing regulator 2.3902
CERK ceramide kinase 2.3889
CTNND1 catenin (cadherin-associated protein), delta 1 2.3859
CD40 CD40 molecule, TNF receptor superfamily member 5 2.38245
NGRN neugrin, neurite outgrowth associated 2.3782
ZC3H3 zinc finger CCCH-type containing 3 2.3757
MED9 mediator complex subunit 9 2.3693
MEF2C myocyte enhancer factor 2C 2.36893
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5 2.3687
VEGFA vascular endothelial growth factor A 2.36733
CASP5 caspase 5, apoptosis-related cysteine peptidase 2.3667
SLN sarcolipin 2.3625
METTL22 methyltransferase like 22 2.3612
EMSY EMSY transcriptional repressor, BRCA2 interacting 2.3545
OXLD1 oxidoreductase-like domain containing 1 2.34835
KCTD15 potassium channel tetramerization domain containing 15 2.3471
CDH5 cadherin 5, type 2 (vascular endothelium) 2.3444
ANXA10 annexin A10 2.344
DHRS9 dehydrogenase/reductase (SDR family) member 9 2.3433
WDR7 WD repeat domain 7 2.3419
PPP1R12B protein phosphatase 1, regulatory subunit 12B 2.33855
TRIB3 tribbles pseudokinase 3 2.3366
ZNF586 zinc finger protein 586 2.3351
VWF von Willebrand factor 2.3348
EPS8L1 EPS8-like 1 2.33394
BET1 Bet1 golgi vesicular membrane trafficking protein 2.3325
GINS1 GINS complex subunit 1 (Psf1 homolog) 2.33
IL36R interleukin 36 receptor 2.3295
REXO5 RNA exonuclease 5 2.3278
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.3277
HYI hydroxypyruvate isomerase (putative) 2.3252
FTCD formimidoyltransferase cyclodeaminase 2.3234
AZGP1 alpha-2-glycoprotein 1, zinc-binding 2.32285
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.3222
PECAM1 platelet/endothelial cell adhesion molecule 1 2.31807
IL18R1 interleukin 18 receptor 1 2.3177
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 2.3135
TNNT3 troponin T type 3 (skeletal, fast) 2.3126
NPR1 natriuretic peptide receptor 1 2.3124
PCDHGA8 protocadherin gamma subfamily A, 8 2.3115
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E 2.3113
KNTC1 kinetochore associated 1 2.3112
GBP2 guanylate binding protein 2, interferon-inducible 2.3093
MMP23B matrix metallopeptidase 23B 2.3054
RND3 Rho family GTPase 3 2.3042
ACADSB acyl-CoA dehydrogenase, short/branched chain 2.3028
ZNF667 zinc finger protein 667 2.3027
ERBB4 erb-b2 receptor tyrosine kinase 4 2.30225
MAPK11 mitogen-activated protein kinase 11 2.30223
MTX1 metaxin 1 2.3012
ARMC1 armadillo repeat containing 1 2.2992
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 2.2976
F2RL1 coagulation factor II (thrombin) receptor-like 1 2.29685
ALKBH4 alkB, alkylation repair homolog 4 (E. coli) 2.2948
IMPACT impact RWD domain protein 2.2919
BCL6 B-cell CLL/lymphoma 6 2.29005
EGLN3 egl-9 family hypoxia-inducible factor 3 2.2896
SBDS Shwachman-Bodian-Diamond syndrome 2.2894
TRO trophinin 2.28883
PGM5 phosphoglucomutase 5 2.2868
GPC5 glypican 5 2.2865
RTL8A retrotransposon Gag like 8A 2.2847
PPP1R16B protein phosphatase 1, regulatory subunit 16B 2.28465
GADD45A growth arrest and DNA-damage-inducible, alpha 2.2823
ZNF250 zinc finger protein 250 2.2816
N4BP1 NEDD4 binding protein 1 2.2792
MYBPC2 myosin binding protein C, fast type 2.2756
SIX3 SIX homeobox 3 2.2748
CDHR2 cadherin-related family member 2 2.2747
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa 2.2717
CREBL2 cAMP responsive element binding protein-like 2 2.27077
CDA cytidine deaminase 2.2702
TBC1D8B TBC1 domain family, member 8B (with GRAM domain) 2.2688
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 2.2688
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 2.26782
SPEG SPEG complex locus 2.2673
HACD3 3-hydroxyacyl-CoA dehydratase 3 2.2668
CSAG2 CSAG family, member 2 2.2636
SNN stannin 2.26215
ARL4C ADP-ribosylation factor-like 4C 2.2617
TNNI2 troponin I type 2 (skeletal, fast) 2.2617
PDLIM3 PDZ and LIM domain 3 2.25855
RFPL3 ret finger protein-like 3 2.2582
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 2.25655
MMP14 matrix metallopeptidase 14 (membrane-inserted) 2.25548
DKK3 dickkopf WNT signaling pathway inhibitor 3 2.2544
SIRPA signal-regulatory protein alpha 2.25313
PALM paralemmin 2.2512
TRIM56 tripartite motif containing 56 2.2508
ANXA9 annexin A9 2.2409
DNAAF5 dynein, axonemal, assembly factor 5 2.2393
GPR65 G protein-coupled receptor 65 2.2392
PLAAT4 phospholipase A and acyltransferase 4 2.2381
USP24 ubiquitin specific peptidase 24 2.238
CTBS chitobiase, di-N-acetyl- 2.23665
PMP22 peripheral myelin protein 22 2.23482
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 2.23385
COL4A1 collagen, type IV, alpha 1 2.23315
EVL Enah/Vasp-like 2.2326
COL17A1 collagen, type XVII, alpha 1 2.2315
CFH complement factor H 2.22816
PALMD palmdelphin 2.2279
CCL7 chemokine (C-C motif) ligand 7 2.2273
TOPBP1 topoisomerase (DNA) II binding protein 1 2.2262
AMPD2 adenosine monophosphate deaminase 2 2.2255
GATAD1 GATA zinc finger domain containing 1 2.2246
NUAK1 NUAK family, SNF1-like kinase, 1 2.2243
AIRIM AFG2 interacting ribosome maturation factor 2.2228
PCDHA9 protocadherin alpha 9 2.2216
PRSS16 protease, serine, 16 (thymus) 2.2196
DAND5 DAN domain family member 5, BMP antagonist 2.2186
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 2.217
CPT2 carnitine palmitoyltransferase 2 2.2138
MOGS mannosyl-oligosaccharide glucosidase 2.2121
ITGB6 integrin, beta 6 2.2121
BCL2A1 BCL2-related protein A1 2.2112
IL15RA interleukin 15 receptor, alpha 2.2107
TLR1 toll-like receptor 1 2.2103
IL18RAP interleukin 18 receptor accessory protein 2.2092
FRMD4B FERM domain containing 4B 2.2074
CRYZL1 crystallin, zeta (quinone reductase)-like 1 2.2068
COL18A1 collagen, type XVIII, alpha 1 2.2046
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.2042
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 2.2042
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa 2.2021
NR5A2 nuclear receptor subfamily 5, group A, member 2 2.2017
CREB1 cAMP responsive element binding protein 1 2.20068
PEX26 peroxisomal biogenesis factor 26 2.2006
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 2.2004
CXCL9 chemokine (C-X-C motif) ligand 9 2.1988
DIPK1A divergent protein kinase domain 1A 2.19675
OSBPL1A oxysterol binding protein-like 1A 2.19495
GTPBP2 GTP binding protein 2 2.1943
FZD1 frizzled class receptor 1 2.1917
BTNL8 butyrophilin-like 8 2.1913
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 2.18957
EDN1 endothelin 1 2.1889
EFNB1 ephrin-B1 2.187
ISL1 ISL LIM homeobox 1 2.1865
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 2.18637
THBS3 thrombospondin 3 2.1863
RFPL2 ret finger protein-like 2 2.1863
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 2.1849
WDR19 WD repeat domain 19 2.1841
DENND5A DENN/MADD domain containing 5A 2.1826
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 2.1816
FBXW11 F-box and WD repeat domain containing 11 2.1814
ETNK2 ethanolamine kinase 2 2.1801
QTRT2 queuine tRNA-ribosyltransferase accessory subunit 2 2.176
NEMP1 nuclear envelope integral membrane protein 1 2.17555
CCDC68 coiled-coil domain containing 68 2.1728
DUSP3 dual specificity phosphatase 3 2.17197
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa 2.1697
SPG11 spastic paraplegia 11 (autosomal recessive) 2.1696
CP ceruloplasmin (ferroxidase) 2.1695
ANKRD40CL ANKRD40 C-terminal like 2.169
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 2.1672
SARM1 sterile alpha and TIR motif containing 1 2.1656
NAMPT nicotinamide phosphoribosyltransferase 2.16505
H2AJ H2A.J histone 2.1646
ARL14 ADP-ribosylation factor-like 14 2.1613
LIPF lipase, gastric 2.1607
PKP2 plakophilin 2 2.1601
FJX1 four jointed box 1 (Drosophila) 2.1575
ACKR3 atypical chemokine receptor 3 2.1543
PLN phospholamban 2.15403
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 2.1538
MEST mesoderm specific transcript 2.1537
INHBB inhibin, beta B 2.1493
ITFG1 integrin alpha FG-GAP repeat containing 1 2.1457
TRIM15 tripartite motif containing 15 2.14453
EMCN endomucin 2.1443
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 2.1443
TEDC2 tubulin epsilon and delta complex 2 2.1438
IL10RB interleukin 10 receptor, beta 2.1421
ATF3 activating transcription factor 3 2.1414
RGCC regulator of cell cycle 2.1389
NSD1 nuclear receptor binding SET domain protein 1 2.1382
EPPK1 epiplakin 1 2.1379
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 2.1356
MTFR1 mitochondrial fission regulator 1 2.13515
OTOR otoraplin 2.1345
ZNF492 zinc finger protein 492 2.1339
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 2.1331
IGFBP5 insulin-like growth factor binding protein 5 2.13188
RMC1 regulator of MON1-CCZ1 2.1312
BCAM basal cell adhesion molecule (Lutheran blood group) 2.1308
PGLYRP1 peptidoglycan recognition protein 1 2.1298
THEMIS2 thymocyte selection associated family member 2 2.12955
CSRNP3 cysteine-serine-rich nuclear protein 3 2.1295
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 2.1293
REC8 REC8 meiotic recombination protein 2.1271
RNF2 ring finger protein 2 2.127
PARP6 poly (ADP-ribose) polymerase family, member 6 2.1263
POLE polymerase (DNA directed), epsilon, catalytic subunit 2.1262
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase 2.1256
IL13RA1 interleukin 13 receptor, alpha 1 2.1234
ECEL1 endothelin converting enzyme-like 1 2.1222
RHOBTB1 Rho-related BTB domain containing 1 2.121
CEP70 centrosomal protein 70kDa 2.1183
TYW2 tRNA wybutosine-synthesizing protein 2 2.1172
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 2.1143
KCNMB4 potassium channel subfamily M regulatory beta subunit 4 2.1124
BYSL bystin-like 2.1111
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 2.1102
EYA4 EYA transcriptional coactivator and phosphatase 4 2.1064
ITGA6 integrin, alpha 6 2.10585
BEST1 bestrophin 1 2.1033
ANGPTL4 angiopoietin-like 4 2.1006
ACP2 acid phosphatase 2, lysosomal 2.0998
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 2.09883
AP3B2 adaptor-related protein complex 3, beta 2 subunit 2.096
CFI complement factor I 2.0947
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 2.0926
TM4SF4 transmembrane 4 L six family member 4 2.0921
NAA80 N-alpha-acetyltransferase 80, NatH catalytic subunit 2.0898
HESX1 HESX homeobox 1 2.0891
TULP3 tubby like protein 3 2.0879
METTL1 methyltransferase like 1 2.0873
ARF3 ADP-ribosylation factor 3 2.08683
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 2.0833
KIF22 kinesin family member 22 2.08215
TMEM127 transmembrane protein 127 2.0809
ARL17B ADP-ribosylation factor-like 17B 2.0806
ANG angiogenin, ribonuclease, RNase A family, 5 2.0797
MRPS10 mitochondrial ribosomal protein S10 2.0786
TRPV6 transient receptor potential cation channel, subfamily V, member 6 2.0782
YIPF4 Yip1 domain family, member 4 2.0767
ORC6 origin recognition complex, subunit 6 2.076
ANGPT1 angiopoietin 1 2.07335
PSORS1C1 psoriasis susceptibility 1 candidate 1 2.0733
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 2.073
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 2.0725
CAV1 caveolin 1, caveolae protein, 22kDa 2.0716
JUN jun proto-oncogene 2.07107
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase 2.0694
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) 2.0674
CFAP298 cilia and flagella associated protein 298 2.0654
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 2.0625
ORC4 origin recognition complex, subunit 4 2.06115
CAMK1D calcium/calmodulin-dependent protein kinase ID 2.0607
HTRA1 HtrA serine peptidase 1 2.0595
DAPK3 death-associated protein kinase 3 2.05825
NUP107 nucleoporin 107kDa 2.0575
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1 2.0572
ERV3-1-ZNF117 ERV3-1-ZNF117 readthrough 2.05405
POU5F1 POU class 5 homeobox 1 2.05402
IL4R interleukin 4 receptor 2.0524
SOD2 superoxide dismutase 2, mitochondrial 2.05132
MTERF4 mitochondrial transcription termination factor 4 2.0507
CPA4 carboxypeptidase A4 2.0502
KLHDC2 kelch domain containing 2 2.0502
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) 2.0499
NRBF2 nuclear receptor binding factor 2 2.0488
ALOX12 arachidonate 12-lipoxygenase 2.0478
STARD5 StAR-related lipid transfer (START) domain containing 5 2.0442
MECOM MDS1 and EVI1 complex locus 2.0435
MCAM melanoma cell adhesion molecule 2.043
GOLGA6L9 golgin A6 family-like 9 2.0421
CD24 CD24 molecule 2.04057
PRKX protein kinase, X-linked 2.03855
SULF1 sulfatase 1 2.03837
GPR171 G protein-coupled receptor 171 2.0376
YEATS4 YEATS domain containing 4 2.0376
PHOX2A paired-like homeobox 2a 2.0373
CDADC1 cytidine and dCMP deaminase domain containing 1 2.0372
STON1 stonin 1 2.0372
DERL1 derlin 1 2.03585
NPTX1 neuronal pentraxin I 2.035
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 2.0346
CYBRD1 cytochrome b reductase 1 2.0315
COG7 component of oligomeric golgi complex 7 2.0311
BIRC3 baculoviral IAP repeat containing 3 2.0302
SOX12 SRY (sex determining region Y)-box 12 2.0292
MRPS11 mitochondrial ribosomal protein S11 2.0278
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 2.0271
GFOD2 glucose-fructose oxidoreductase domain containing 2 2.02675
HYOU1 hypoxia up-regulated 1 2.0216
CNN3 calponin 3, acidic 2.0204
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 2.0195
GDAP1 ganglioside induced differentiation associated protein 1 2.0186
TMEM135 transmembrane protein 135 2.0174
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 2.01707
GPR4 G protein-coupled receptor 4 2.015
RPGRIP1L RPGRIP1-like 2.014
ARHGAP8 Rho GTPase activating protein 8 2.01235
CAMKV CaM kinase-like vesicle-associated 2.0121
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa 2.0118
CCDC57 coiled-coil domain containing 57 2.0117
FPR2 formyl peptide receptor 2 2.01105
PDE1B phosphodiesterase 1B, calmodulin-dependent 2.0095
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 2.00825
TNNT1 troponin T type 1 (skeletal, slow) 2.0074
OSTM1 osteopetrosis associated transmembrane protein 1 2.0069
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 2.0046
HPCA hippocalcin 2.002
PHACTR4 phosphatase and actin regulator 4 2.0017
LSP1 lymphocyte-specific protein 1 2.0016
ORM1 orosomucoid 1 2.0004

decreased expression

Symbol Name Standardized Value
HSPA8 heat shock 70kDa protein 8 -10.0
ENOPH1 enolase-phosphatase 1 -10.0
TM9SF3 transmembrane 9 superfamily member 3 -10.0
RPIA ribose 5-phosphate isomerase A -10.0
BASP1 brain abundant, membrane attached signal protein 1 -5.9752
PCCB propionyl CoA carboxylase, beta polypeptide -5.8985
CD81 CD81 molecule -5.6539
ANXA2 annexin A2 -5.3993
BLCAP bladder cancer associated protein -5.2892
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -5.20997
PIH1D1 PIH1 domain containing 1 -4.3749
FBXO7 F-box protein 7 -4.2943
MLEC malectin -4.2185
TMEM9B TMEM9 domain family, member B -3.9948
CBR3 carbonyl reductase 3 -3.984
RPS5 ribosomal protein S5 -3.9592
SORBS3 sorbin and SH3 domain containing 3 -3.89375
CH25H cholesterol 25-hydroxylase -3.7729
SH3YL1 SH3 and SYLF domain containing 1 -3.7264
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -3.7027
FOXO4 forkhead box O4 -3.7017
PRCP prolylcarboxypeptidase (angiotensinase C) -3.6416
TSG101 tumor susceptibility 101 -3.6268
RPN1 ribophorin I -3.56
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -3.26973
FASTKD5 FAST kinase domains 5 -3.254
RPL21 ribosomal protein L21 -3.189
PTS 6-pyruvoyltetrahydropterin synthase -3.1799
RNF11 ring finger protein 11 -3.1737
COPS4 COP9 signalosome subunit 4 -3.1626
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 -3.1609
TAC4 tachykinin 4 (hemokinin) -3.1068
APLP2 amyloid beta (A4) precursor-like protein 2 -3.09285
POLR1A polymerase (RNA) I polypeptide A, 194kDa -3.07385
ILK integrin-linked kinase -3.0728
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa -3.0651
MYC v-myc avian myelocytomatosis viral oncogene homolog -2.9983
UBB ubiquitin B -2.9903
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 -2.98525
RPL34 ribosomal protein L34 -2.9758
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 -2.9524
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) -2.928
CDC20 cell division cycle 20 -2.928
EIF3L eukaryotic translation initiation factor 3, subunit L -2.9259
SLC41A3 solute carrier family 41, member 3 -2.8588
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.83935
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 -2.749
MRPL3 mitochondrial ribosomal protein L3 -2.7484
GRAMD2B GRAM domain containing 2B -2.7471
RPS13 ribosomal protein S13 -2.7222
RBM15B RNA binding motif protein 15B -2.718
NPTN neuroplastin -2.7095
FBL fibrillarin -2.7051
TUBG1 tubulin, gamma 1 -2.6947
MOXD1 monooxygenase, DBH-like 1 -2.6901
DCPS decapping enzyme, scavenger -2.6646
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic -2.662
SEC31A SEC31 homolog A (S. cerevisiae) -2.6596
MAGED1 melanoma antigen family D1 -2.6468
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -2.6449
PPP6R1 protein phosphatase 6, regulatory subunit 1 -2.6437
IGBP1 immunoglobulin (CD79A) binding protein 1 -2.6328
PPP1R8 protein phosphatase 1, regulatory subunit 8 -2.6297
PPIH peptidylprolyl isomerase H (cyclophilin H) -2.624
NAV3 neuron navigator 3 -2.6073
PUM3 pumilio RNA binding family member 3 -2.6029
NKX2-2 NK2 homeobox 2 -2.6013
COMMD1 copper metabolism (Murr1) domain containing 1 -2.5953
ARAF A-Raf proto-oncogene, serine/threonine kinase -2.5916
RPL6 ribosomal protein L6 -2.5915
SLC26A2 solute carrier family 26 (anion exchanger), member 2 -2.5799
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.5747
THTPA thiamine triphosphatase -2.5709
HEXB hexosaminidase B (beta polypeptide) -2.561
NPC2 Niemann-Pick disease, type C2 -2.5567
MKNK1 MAP kinase interacting serine/threonine kinase 1 -2.5428
NOP53 NOP53 ribosome biogenesis factor -2.5381
TMEM109 transmembrane protein 109 -2.5357
RPL19 ribosomal protein L19 -2.5293
CTSL cathepsin L -2.5207
RPS16 ribosomal protein S16 -2.5119
EI24 etoposide induced 2.4 -2.4904
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -2.4845
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa -2.4748
GLRX5 glutaredoxin 5 -2.4679
GLB1 galactosidase, beta 1 -2.4655
ANXA5 annexin A5 -2.4646
ACTG1 actin gamma 1 -2.46438
EIF3D eukaryotic translation initiation factor 3, subunit D -2.4599
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -2.45645
TALDO1 transaldolase 1 -2.4499
RPL27 ribosomal protein L27 -2.441
STX18 syntaxin 18 -2.4351
FCGRT Fc fragment of IgG, receptor, transporter, alpha -2.4081
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.4017
HOMER1 homer scaffolding protein 1 -2.3988
THAP12 THAP domain containing 12 -2.3966
OTUD3 OTU deubiquitinase 3 -2.3961
CRTAP cartilage associated protein -2.3931
TXLNA taxilin alpha -2.3871
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) -2.383
YAF2 YY1 associated factor 2 -2.3795
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -2.3743
TEX10 testis expressed 10 -2.3714
ZCCHC24 zinc finger, CCHC domain containing 24 -2.3711
RPS4X ribosomal protein S4, X-linked -2.3692
RPL4 ribosomal protein L4 -2.36833
NLGN4X neuroligin 4, X-linked -2.3633
TBCA tubulin folding cofactor A -2.3584
RPL32 ribosomal protein L32 -2.3572
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -2.35535
RPS3A ribosomal protein S3A -2.35483
RANGRF RAN guanine nucleotide release factor -2.3483
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -2.3475
COPB1 coatomer protein complex, subunit beta 1 -2.3463
RTRAF RNA transcription, translation and transport factor -2.3462
NCOA6 nuclear receptor coactivator 6 -2.3346
GLOD4 glyoxalase domain containing 4 -2.3295
CDC25B cell division cycle 25B -2.3293
LMNA lamin A/C -2.32755
SPA17 sperm autoantigenic protein 17 -2.3223
EXOC3 exocyst complex component 3 -2.3179
NME2 NME/NM23 nucleoside diphosphate kinase 2 -2.3129
KLC1 kinesin light chain 1 -2.3022
RPL39 ribosomal protein L39 -2.3011
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -2.2999
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.2987
CCT3 chaperonin containing TCP1, subunit 3 (gamma) -2.2947
MTCH1 mitochondrial carrier 1 -2.2937
CST3 cystatin C -2.2912
MKRN1 makorin ring finger protein 1 -2.28195
PRPS2 phosphoribosyl pyrophosphate synthetase 2 -2.2783
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 -2.2642
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 -2.2641
MKRN2 makorin ring finger protein 2 -2.2632
CD320 CD320 molecule -2.2613
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 -2.2587
RPL8 ribosomal protein L8 -2.2574
ARF1 ADP-ribosylation factor 1 -2.2549
PRMT5 protein arginine methyltransferase 5 -2.2527
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -2.24892
RPL9 ribosomal protein L9 -2.2474
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.2462
MRPL23 mitochondrial ribosomal protein L23 -2.2406
DAD1 defender against cell death 1 -2.2393
HMGN2 high mobility group nucleosomal binding domain 2 -2.2392
NBPF3 neuroblastoma breakpoint family, member 3 -2.2366
LY86 lymphocyte antigen 86 -2.234
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) -2.22575
RPS19 ribosomal protein S19 -2.22575
VCP valosin containing protein -2.22305
SYNE3 spectrin repeat containing, nuclear envelope family member 3 -2.223
PROS1 protein S (alpha) -2.2165
CHIC2 cysteine-rich hydrophobic domain 2 -2.2155
RPS29 ribosomal protein S29 -2.2108
SKP1 S-phase kinase-associated protein 1 -2.20993
GNB5 guanine nucleotide binding protein (G protein), beta 5 -2.20957
WFDC2 WAP four-disulfide core domain 2 -2.2075
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -2.2057
SF3B5 splicing factor 3b, subunit 5, 10kDa -2.2037
RPS27 ribosomal protein S27 -2.2037
RBM7 RNA binding motif protein 7 -2.2011
YLPM1 YLP motif containing 1 -2.19893
RPS23 ribosomal protein S23 -2.1972
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -2.1947
EIF6 eukaryotic translation initiation factor 6 -2.1929
MSANTD2 Myb/SANT-like DNA-binding domain containing 2 -2.1875
CNIH1 cornichon family AMPA receptor auxiliary protein 1 -2.185
CTSW cathepsin W -2.1761
ERCC1 excision repair cross-complementation group 1 -2.1756
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta -2.174
TUBA1C tubulin, alpha 1c -2.1738
CCNI cyclin I -2.17167
RPP30 ribonuclease P/MRP 30kDa subunit -2.1709
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor -2.1703
RPL38 ribosomal protein L38 -2.1686
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 -2.1677
SIAH2 siah E3 ubiquitin protein ligase 2 -2.164
SLC35B1 solute carrier family 35, member B1 -2.1638
EPS8 epidermal growth factor receptor pathway substrate 8 -2.1604
MRPS2 mitochondrial ribosomal protein S2 -2.1584
HNRNPM heterogeneous nuclear ribonucleoprotein M -2.1576
RPS12 ribosomal protein S12 -2.1562
IRX5 iroquois homeobox 5 -2.1529
SYNGR3 synaptogyrin 3 -2.1517
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) -2.1513
PLS1 plastin 1 -2.1509
PACS2 phosphofurin acidic cluster sorting protein 2 -2.1438
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) -2.1383
ZNF862 zinc finger protein 862 -2.1358
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin -2.1325
RAB1B RAB1B, member RAS oncogene family -2.1293
TOP2B topoisomerase (DNA) II beta 180kDa -2.1265
C2CD5 C2 calcium-dependent domain containing 5 -2.1258
ACTR10 actin-related protein 10 homolog (S. cerevisiae) -2.1242
OAZ1 ornithine decarboxylase antizyme 1 -2.1227
GPKOW G patch domain and KOW motifs -2.1189
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa -2.1157
AATF apoptosis antagonizing transcription factor -2.1143
MXRA7 matrix-remodelling associated 7 -2.1131
ATP5MG ATP synthase membrane subunit g -2.11258
SRFBP1 serum response factor binding protein 1 -2.1109
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.1076
TUBA1B tubulin, alpha 1b -2.1047
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa -2.104
NIT2 nitrilase family, member 2 -2.1036
RPS15A ribosomal protein S15a -2.1014
ABHD14A abhydrolase domain containing 14A -2.0998
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -2.0996
MORF4L1 mortality factor 4 like 1 -2.09845
THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) -2.0974
CCT4 chaperonin containing TCP1, subunit 4 (delta) -2.0966
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain -2.09645
USF2 upstream transcription factor 2, c-fos interacting -2.09317
IPO7 importin 7 -2.09115
RPL7 ribosomal protein L7 -2.0902
RPL11 ribosomal protein L11 -2.088
RPS25 ribosomal protein S25 -2.0841
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 -2.0806
RPLP1 ribosomal protein, large, P1 -2.0771
PEAK1 pseudopodium-enriched atypical kinase 1 -2.0766
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 -2.0749
ARCN1 archain 1 -2.0748
RPL41 ribosomal protein L41 -2.0697
THYN1 thymocyte nuclear protein 1 -2.0668
RALY RALY heterogeneous nuclear ribonucleoprotein -2.0668
SLF2 SMC5-SMC6 complex localization factor 2 -2.06325
IRF8 interferon regulatory factor 8 -2.0599
AZU1 azurocidin 1 -2.0562
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 -2.05577
LASP1 LIM and SH3 protein 1 -2.0549
PARP2 poly (ADP-ribose) polymerase 2 -2.05403
RPLP0 ribosomal protein, large, P0 -2.05214
ARF6 ADP-ribosylation factor 6 -2.04935
ERMP1 endoplasmic reticulum metallopeptidase 1 -2.0487
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -2.0476
RPL30 ribosomal protein L30 -2.0472
PPA2 pyrophosphatase (inorganic) 2 -2.0466
GTF2H5 general transcription factor IIH, polypeptide 5 -2.0458
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 -2.0448
BACE2 beta-site APP-cleaving enzyme 2 -2.0432
PRNP prion protein -2.04273
R3HDM2 R3H domain containing 2 -2.0424
ARHGAP19 Rho GTPase activating protein 19 -2.0368
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -2.0348
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) -2.0326
DYNLRB1 dynein, light chain, roadblock-type 1 -2.0292
PNKP polynucleotide kinase 3'-phosphatase -2.0287
CCDC92 coiled-coil domain containing 92 -2.0276
AP2S1 adaptor-related protein complex 2, sigma 1 subunit -2.02717
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) -2.0257
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.022
TPT1 tumor protein, translationally-controlled 1 -2.02057
EFHD2 EF-hand domain family, member D2 -2.0195
RPS10 ribosomal protein S10 -2.0191
PINLYP phospholipase A2 inhibitor and LY6/PLAUR domain containing -2.0166
CPNE3 copine III -2.0153
LRRC59 leucine rich repeat containing 59 -2.015
NNT nicotinamide nucleotide transhydrogenase -2.00525
RAB4B RAB4B, member RAS oncogene family -2.0024
RIC8A RIC8 guanine nucleotide exchange factor A -2.0019