CRCGN015_MCF10A.TP53.M_24H:P17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description amsonic acid 33.52 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

85 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:P17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 5.12845
KLHL21 kelch-like family member 21 5.08355
FKBP14 FK506 binding protein 14, 22 kDa 4.9039
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.46002
KDM5D lysine (K)-specific demethylase 5D 4.3063
TLCD3A TLC domain containing 3A 4.2678
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 4.1644
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 3.71837
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 3.69222
ACAA1 acetyl-CoA acyltransferase 1 3.53415
MCUR1 mitochondrial calcium uniporter regulator 1 3.33485
SBNO1 strawberry notch homolog 1 (Drosophila) 3.2705
MTA2 metastasis associated 1 family, member 2 3.151
TPD52L2 tumor protein D52-like 2 3.1089
HBA1 hemoglobin, alpha 1 2.71146
HLA-DRA major histocompatibility complex, class II, DR alpha 2.68407
PRPF39 pre-mRNA processing factor 39 2.6232
CEPT1 choline/ethanolamine phosphotransferase 1 2.5756
COMP cartilage oligomeric matrix protein 2.5354
RWDD1 RWD domain containing 1 2.50345
RBBP5 retinoblastoma binding protein 5 2.40645
SRSF6 serine/arginine-rich splicing factor 6 2.39028
RPS4Y1 ribosomal protein S4, Y-linked 1 2.3881
GNG10 guanine nucleotide binding protein (G protein), gamma 10 2.3878
USP9Y ubiquitin specific peptidase 9, Y-linked 2.38303
OLFML2B olfactomedin-like 2B 2.36835
TFB2M transcription factor B2, mitochondrial 2.31135
PIGH phosphatidylinositol glycan anchor biosynthesis, class H 2.2686
THRAP3 thyroid hormone receptor associated protein 3 2.207
KAT6B K(lysine) acetyltransferase 6B 2.18744
IL18 interleukin 18 2.1844
TOMM34 translocase of outer mitochondrial membrane 34 2.1701
S100A2 S100 calcium binding protein A2 2.14815
WDR12 WD repeat domain 12 2.0799
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) 2.07265
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase 2.0481
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit 2.00995
TMEM168 transmembrane protein 168 2.00575

decreased expression

Symbol Name Standardized Value
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -4.97715
KDM5C lysine (K)-specific demethylase 5C -4.0803
ATF5 activating transcription factor 5 -3.56573
SMC1A structural maintenance of chromosomes 1A -3.3249
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -3.15217
SGK1 serum/glucocorticoid regulated kinase 1 -3.06225
PUDP pseudouridine 5'-phosphatase -2.9394
TBCB tubulin folding cofactor B -2.80343
UBA1 ubiquitin-like modifier activating enzyme 1 -2.70735
USP9X ubiquitin specific peptidase 9, X-linked -2.64932
RBM42 RNA binding motif protein 42 -2.59575
ZSCAN9 zinc finger and SCAN domain containing 9 -2.5388
CRIPTO3 cripto, EGF-CFC family member 3 -2.49815
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 -2.48785
RUBCNL rubicon like autophagy enhancer -2.39385
ZC2HC1C zinc finger, C2HC-type containing 1C -2.3864
KMT2B lysine (K)-specific methyltransferase 2B -2.38263
CRYBB1 crystallin, beta B1 -2.37865
DOC2A double C2-like domains, alpha -2.3576
LIN37 lin-37 DREAM MuvB core complex component -2.31315
KDM6A lysine (K)-specific demethylase 6A -2.29497
PNPLA4 patatin-like phospholipase domain containing 4 -2.27145
TMEM53 transmembrane protein 53 -2.26875
UBASH3A ubiquitin associated and SH3 domain containing A -2.26755
ZNF331 zinc finger protein 331 -2.23525
KCNK12 potassium channel, two pore domain subfamily K, member 12 -2.21445
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -2.20053
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) -2.1581
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta -2.1443
KEL Kell blood group, metallo-endopeptidase -2.1237
GRM4 glutamate receptor, metabotropic 4 -2.11575
NCF4 neutrophil cytosolic factor 4, 40kDa -2.10805
SHBG sex hormone-binding globulin -2.10765
LRFN3 leucine rich repeat and fibronectin type III domain containing 3 -2.1027
KCTD13 potassium channel tetramerization domain containing 13 -2.1013
CAPNS1 calpain, small subunit 1 -2.08385
ERO1B endoplasmic reticulum oxidoreductase 1 beta -2.0812
FOXH1 forkhead box H1 -2.0807
GID4 GID complex subunit 4 -2.08055
LAS1L LAS1-like (S. cerevisiae) -2.07665
ACOT13 acyl-CoA thioesterase 13 -2.06955
TSGA10 testis specific, 10 -2.0441
DEFA4 defensin, alpha 4, corticostatin -2.02985
SERGEF secretion regulating guanine nucleotide exchange factor -2.0267
MYL5 myosin, light chain 5, regulatory -2.0208
SLC17A4 solute carrier family 17, member 4 -2.01985
WNT3 wingless-type MMTV integration site family, member 3 -2.009