CRCGN015_MCF10A.TP53.M_24H:P20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description spironolactone 33.72 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

592 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:P20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
FKBP14 FK506 binding protein 14, 22 kDa 6.72705
FHL2 four and a half LIM domains 2 6.0629
TMEM50A transmembrane protein 50A 6.04215
H2BC12 H2B clustered histone 12 5.74778
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 5.69795
DEF8 differentially expressed in FDCP 8 homolog (mouse) 4.97505
UGDH UDP-glucose 6-dehydrogenase 4.562
GFOD1 glucose-fructose oxidoreductase domain containing 1 4.18995
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 3.6163
IL1B interleukin 1, beta 3.40885
TUFT1 tuftelin 1 3.3914
CHUK conserved helix-loop-helix ubiquitous kinase 3.3659
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 3.36163
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa 3.33885
GBP1 guanylate binding protein 1, interferon-inducible 3.2775
CRYZ crystallin, zeta (quinone reductase) 3.27135
TBCC tubulin folding cofactor C 3.24845
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 3.1809
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 3.1414
TRAPPC6A trafficking protein particle complex 6A 3.1359
DUSP14 dual specificity phosphatase 14 3.1284
GTPBP8 GTP-binding protein 8 (putative) 3.1245
NKX6-1 NK6 homeobox 1 3.10675
GTF2B general transcription factor IIB 3.08955
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.07715
NDEL1 nudE neurodevelopment protein 1-like 1 3.0744
H2BC9 H2B clustered histone 9 3.06625
TIGAR TP53 induced glycolysis regulatory phosphatase 3.03515
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.03415
COL5A1 collagen, type V, alpha 1 3.02267
IGF1R insulin-like growth factor 1 receptor 3.01768
SP140L SP140 nuclear body protein-like 2.9909
SAMD9 sterile alpha motif domain containing 9 2.9744
NLRP2B NLR family pyrin domain containing 2B 2.97415
ZDHHC6 zinc finger, DHHC-type containing 6 2.95995
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.9408
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32 2.93195
H2AC6 H2A clustered histone 6 2.9256
WNT16 wingless-type MMTV integration site family, member 16 2.9236
S100A4 S100 calcium binding protein A4 2.9186
TUBA4B tubulin, alpha 4b 2.9147
STK17A serine/threonine kinase 17a 2.89892
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.886
MREG melanoregulin 2.8787
PTK7 protein tyrosine kinase 7 (inactive) 2.8505
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 2.84765
COL4A1 collagen, type IV, alpha 1 2.84672
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.84523
DCTN6 dynactin 6 2.83375
SPEG SPEG complex locus 2.82205
ECD ecdysoneless homolog (Drosophila) 2.8066
PUM3 pumilio RNA binding family member 3 2.79885
NME7 NME/NM23 family member 7 2.7874
CRIPT cysteine-rich PDZ-binding protein 2.7856
MSRA methionine sulfoxide reductase A 2.782
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D 2.77647
AIM2 absent in melanoma 2 2.77315
EPHA2 EPH receptor A2 2.7716
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 2.7625
CHPF2 chondroitin polymerizing factor 2 2.7617
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 2.7469
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like) 2.73137
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 2.7207
CREG1 cellular repressor of E1A-stimulated genes 1 2.71405
HOXA1 homeobox A1 2.71085
OMG oligodendrocyte myelin glycoprotein 2.69995
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.6899
EPPK1 epiplakin 1 2.68795
SMNDC1 survival motor neuron domain containing 1 2.68195
ZNF10 zinc finger protein 10 2.66325
CEMIP2 cell migration inducing hyaluronidase 2 2.66255
EHD4 EH-domain containing 4 2.65665
NOP10 NOP10 ribonucleoprotein 2.64975
IFNG interferon, gamma 2.6232
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 2.60665
H1-2 H1.2 linker histone, cluster member 2.60595
TSC1 tuberous sclerosis 1 2.60585
MICB MHC class I polypeptide-related sequence B 2.60435
ULBP2 UL16 binding protein 2 2.60075
IFRD1 interferon-related developmental regulator 1 2.59735
DHRS7 dehydrogenase/reductase (SDR family) member 7 2.5958
IKZF5 IKAROS family zinc finger 5 (Pegasus) 2.59345
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 2.5832
H2BC11 H2B clustered histone 11 2.5828
MAD2L1BP MAD2L1 binding protein 2.57275
H2AC19 H2A clustered histone 19 2.57092
TGDS TDP-glucose 4,6-dehydratase 2.56305
BCL2A1 BCL2-related protein A1 2.55795
SAR1B secretion associated, Ras related GTPase 1B 2.5463
CD58 CD58 molecule 2.54598
ANGPT4 angiopoietin 4 2.54595
PRPF38B pre-mRNA processing factor 38B 2.52053
MINPP1 multiple inositol-polyphosphate phosphatase 1 2.51425
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 2.51425
WTAP Wilms tumor 1 associated protein 2.50455
BIK BCL2-interacting killer (apoptosis-inducing) 2.50135
MTCH1 mitochondrial carrier 1 2.4999
CXCL8 chemokine (C-X-C motif) ligand 8 2.49897
PLAU plasminogen activator, urokinase 2.4945
TBC1D31 TBC1 domain family, member 31 2.4942
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) 2.49205
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.4901
TASOR2 transcription activation suppressor family member 2 2.48345
BTK Bruton agammaglobulinemia tyrosine kinase 2.47675
HACD3 3-hydroxyacyl-CoA dehydratase 3 2.4701
BLZF1 basic leucine zipper nuclear factor 1 2.46957
SUCO SUN domain containing ossification factor 2.4687
F2RL2 coagulation factor II (thrombin) receptor-like 2 2.468
PLEK2 pleckstrin 2 2.4654
IFT22 intraflagellar transport 22 2.465
CAB39 calcium binding protein 39 2.46445
H2AC7 H2A clustered histone 7 2.4589
CDK7 cyclin-dependent kinase 7 2.45455
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 2.45445
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 2.44578
BCAP29 B-cell receptor-associated protein 29 2.43695
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 2.43073
SH2D2A SH2 domain containing 2A 2.42795
TBC1D10C TBC1 domain family, member 10C 2.4229
S100G S100 calcium binding protein G 2.4215
ZNF195 zinc finger protein 195 2.4211
CCL3L3 chemokine (C-C motif) ligand 3-like 3 2.42105
IL18 interleukin 18 2.4132
ZNF536 zinc finger protein 536 2.41225
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 2.41055
MXD1 MAX dimerization protein 1 2.4101
GADD45A growth arrest and DNA-damage-inducible, alpha 2.39795
RAB8A RAB8A, member RAS oncogene family 2.3966
PTPN7 protein tyrosine phosphatase, non-receptor type 7 2.3912
GLIPR1 GLI pathogenesis-related 1 2.39047
TMEM132A transmembrane protein 132A 2.3877
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa 2.3872
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 2.38385
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 2.38295
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa 2.3792
IFT54 intraflagellar transport 54 2.36945
SFT2D2 SFT2 domain containing 2 2.36455
MNDA myeloid cell nuclear differentiation antigen 2.36085
IL13RA1 interleukin 13 receptor, alpha 1 2.35889
BRIX1 BRX1, biogenesis of ribosomes 2.35375
TDO2 tryptophan 2,3-dioxygenase 2.3511
H2BC4 H2B clustered histone 4 2.33676
FZD6 frizzled class receptor 6 2.33485
MED23 mediator complex subunit 23 2.3332
SCAF4 SR-related CTD-associated factor 4 2.33267
TIMP2 TIMP metallopeptidase inhibitor 2 2.33
HMOX1 heme oxygenase 1 2.32525
SCFD1 sec1 family domain containing 1 2.32395
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 2.32315
MEPE matrix extracellular phosphoglycoprotein 2.3212
ZNF23 zinc finger protein 23 2.3141
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 2.31247
IGSF6 immunoglobulin superfamily, member 6 2.30885
PRAMEF10 PRAME family member 10 2.3056
PLEK pleckstrin 2.30468
SNX3 sorting nexin 3 2.30463
TCP10L t-complex 10-like 2.2974
GOLT1B golgi transport 1B 2.2951
KRT17 keratin 17, type I 2.2896
H2BC5 H2B clustered histone 5 2.2896
RUBCN rubicon autophagy regulator 2.2872
RIPPLY2-CYB5R4 RIPPLY2-CYB5R4 readthrough 2.285
KRT16 keratin 16, type I 2.28415
ADAM12 ADAM metallopeptidase domain 12 2.28302
CRABP2 cellular retinoic acid binding protein 2 2.2827
EIF5A2 eukaryotic translation initiation factor 5A2 2.2811
ZNF14 zinc finger protein 14 2.2792
MARCHF5 membrane associated ring-CH-type finger 5 2.27895
LOC127933115 uncharacterized LOC127933115 2.2739
MOSPD1 motile sperm domain containing 1 2.27305
IL21 interleukin 21 2.272
ACTN4 actinin, alpha 4 2.2682
DDA1 DET1 and DDB1 associated 1 2.2644
BLNK B-cell linker 2.26085
KIF21B kinesin family member 21B 2.25925
RANBP6 RAN binding protein 6 2.25855
COA7 cytochrome c oxidase assembly factor 7 (putative) 2.25845
EPHB2 EPH receptor B2 2.25779
RASAL2 RAS protein activator like 2 2.25755
EIF3J eukaryotic translation initiation factor 3, subunit J 2.25637
UBE2G1 ubiquitin-conjugating enzyme E2G 1 2.25615
SYNDIG1 synapse differentiation inducing 1 2.25605
PUM1 pumilio RNA-binding family member 1 2.2507
HOXA6 homeobox A6 2.24775
BAK1 BCL2-antagonist/killer 1 2.24725
CDPF1 cysteine-rich, DPF motif domain containing 1 2.24475
TPM4 tropomyosin 4 2.24323
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 2.24235
PTHLH parathyroid hormone-like hormone 2.2358
CLIC4 chloride intracellular channel 4 2.23397
CYRIB CYFIP related Rac1 interactor B 2.23135
FERRY3 FERRY endosomal RAB5 effector complex subunit 3 2.2305
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 2.2304
LTA lymphotoxin alpha 2.22965
UEVLD UEV and lactate/malate dehyrogenase domains 2.22775
VCPKMT valosin containing protein lysine (K) methyltransferase 2.2271
PERP PERP, TP53 apoptosis effector 2.2249
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 2.22315
RNF111 ring finger protein 111 2.2193
CCDC92 coiled-coil domain containing 92 2.2192
LRRC40 leucine rich repeat containing 40 2.219
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 2.2175
PDLIM7 PDZ and LIM domain 7 (enigma) 2.21686
LOC122526780 uncharacterized LOC122526780 2.2147
VNN2 vanin 2 2.21405
RLF rearranged L-myc fusion 2.2139
POU3F4 POU class 3 homeobox 4 2.21205
SLC67A2 solute carrier family 67 member 2 2.2112
PPME1 protein phosphatase methylesterase 1 2.20645
E2F5 E2F transcription factor 5, p130-binding 2.20545
RSF1 remodeling and spacing factor 1 2.20425
ARF4 ADP-ribosylation factor 4 2.19953
PAQR3 progestin and adipoQ receptor family member III 2.19585
HPGDS hematopoietic prostaglandin D synthase 2.19525
ASB7 ankyrin repeat and SOCS box containing 7 2.19435
RMDN3 regulator of microtubule dynamics 3 2.18895
UBE2A ubiquitin-conjugating enzyme E2A 2.18585
TBC1D19 TBC1 domain family, member 19 2.1855
YIPF5 Yip1 domain family, member 5 2.18335
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 2.18295
TMEM59 transmembrane protein 59 2.18265
MARK3 MAP/microtubule affinity-regulating kinase 3 2.1808
ATG4A autophagy related 4A, cysteine peptidase 2.18005
TPD52-MRPS28 TPD52-MRPS28 readthrough 2.18001
CADM1 cell adhesion molecule 1 2.17907
RIOK3 RIO kinase 3 2.17625
RMC1 regulator of MON1-CCZ1 2.1731
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 2.1696
PEG10 paternally expressed 10 2.1692
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 2.1687
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 2.16135
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 2.15508
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 2.15445
IL2 interleukin 2 2.15315
SRF serum response factor (c-fos serum response element-binding transcription factor) 2.15278
TMEM158 transmembrane protein 158 (gene/pseudogene) 2.15235
CEMIP cell migration inducing protein, hyaluronan binding 2.15
FRS2 fibroblast growth factor receptor substrate 2 2.14875
PI3 peptidase inhibitor 3, skin-derived 2.14847
KDM7A lysine (K)-specific demethylase 7A 2.1429
ZMPSTE24 zinc metallopeptidase STE24 2.1418
HOXA11 homeobox A11 2.14145
ANGPTL2 angiopoietin-like 2 2.14103
POLR1D polymerase (RNA) I polypeptide D, 16kDa 2.133
INPP1 inositol polyphosphate-1-phosphatase 2.12985
MSTN myostatin 2.12965
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase 2.12825
CDKL3 cyclin-dependent kinase-like 3 2.1233
CTLA4 cytotoxic T-lymphocyte-associated protein 4 2.1219
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 2.11901
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 2.11767
CHAMP1 chromosome alignment maintaining phosphoprotein 1 2.10715
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 2.1068
NLK nemo-like kinase 2.1058
TMEM9B TMEM9 domain family, member B 2.1047
ZXDB zinc finger, X-linked, duplicated B 2.0984
SSTR5 somatostatin receptor 5 2.09505
HCCS holocytochrome c synthase 2.09328
MYO7A myosin VIIA 2.09276
TRIT1 tRNA isopentenyltransferase 1 2.0921
HOXA3 homeobox A3 2.0918
EDA2R ectodysplasin A2 receptor 2.09165
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 2.08703
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 2.08685
RUNX3 runt-related transcription factor 3 2.08673
SLC38A1 solute carrier family 38, member 1 2.08319
CLDN17 claudin 17 2.0827
DEFA4 defensin, alpha 4, corticostatin 2.07725
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 2.07415
RABGGTB Rab geranylgeranyltransferase, beta subunit 2.07347
SNRNP27 small nuclear ribonucleoprotein 27kDa (U4/U6.U5) 2.07312
GPC1 glypican 1 2.07273
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 2.07075
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 2.0702
SNX4 sorting nexin 4 2.06782
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4 2.066
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 2.06505
ANTXR1 anthrax toxin receptor 1 2.0648
KDM2A lysine (K)-specific demethylase 2A 2.06342
TSPAN6 tetraspanin 6 2.06112
EOLA1 endothelium and lymphocyte associated ASCH domain 1 2.05892
NIPAL2 NIPA-like domain containing 2 2.0571
WNT7B wingless-type MMTV integration site family, member 7B 2.0562
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 2.05485
RNF39 ring finger protein 39 2.0546
UBR2 ubiquitin protein ligase E3 component n-recognin 2 2.0534
GRAMD2B GRAM domain containing 2B 2.0521
EXO5 exonuclease 5 2.049
ZC3H12A zinc finger CCCH-type containing 12A 2.0458
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.04495
TGM1 transglutaminase 1 2.04475
LMTK2 lemur tyrosine kinase 2 2.04385
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 2.04307
PAQR5 progestin and adipoQ receptor family member V 2.0416
NEUROG1 neurogenin 1 2.0376
LMX1B LIM homeobox transcription factor 1, beta 2.03655
SP100 SP100 nuclear antigen 2.03583
TWSG1 twisted gastrulation BMP signaling modulator 1 2.0358
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 2.03385
MED17 mediator complex subunit 17 2.03235
ADAM19 ADAM metallopeptidase domain 19 2.03115
RINT1 RAD50 interactor 1 2.0304
TMEM156 transmembrane protein 156 2.03
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 2.0299
LTC4S leukotriene C4 synthase 2.0297
SLAMF8 SLAM family member 8 2.02825
ADORA2A adenosine A2a receptor 2.0255
CEP83 centrosomal protein 83kDa 2.02375
MSX2 msh homeobox 2 2.02332
CA2 carbonic anhydrase II 2.0221
TNFAIP8L2-SCNM1 TNFAIP8L2-SCNM1 readthrough 2.02125
ABRAXAS2 abraxas 2, BRISC complex subunit 2.02052
CTSK cathepsin K 2.02035
KISS1 KiSS-1 metastasis-suppressor 2.01985
DENND2D DENN/MADD domain containing 2D 2.0181
MTUS2 microtubule associated tumor suppressor candidate 2 2.0168
OR10H1 olfactory receptor, family 10, subfamily H, member 1 2.01665
BMP1 bone morphogenetic protein 1 2.01493
HCAR3 hydroxycarboxylic acid receptor 3 2.01465
IL22 interleukin 22 2.012
RBM15 RNA binding motif protein 15 2.01143
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 2.01135
LHX1 LIM homeobox 1 2.01125
YIPF1 Yip1 domain family, member 1 2.01055
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 2.01045
LRRC61 leucine rich repeat containing 61 2.01035
ICOS inducible T-cell co-stimulator 2.00875
RBBP5 retinoblastoma binding protein 5 2.00785
PCDH7 protocadherin 7 2.00716
SRFBP1 serum response factor binding protein 1 2.0059
IL21R interleukin 21 receptor 2.00417
EPHB3 EPH receptor B3 2.00238
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 2.00123

decreased expression

Symbol Name Standardized Value
DDIT4 DNA-damage-inducible transcript 4 -9.86745
NLRP4 NLR family, pyrin domain containing 4 -8.1048
CRTAP cartilage associated protein -7.7337
CDC45 cell division cycle 45 -7.5724
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.0538
HAT1 histone acetyltransferase 1 -5.9719
INTS3 integrator complex subunit 3 -5.412
NUP85 nucleoporin 85kDa -5.38715
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -5.3335
TRAP1 TNF receptor-associated protein 1 -5.1128
SPAG7 sperm associated antigen 7 -5.05195
OXA1L oxidase (cytochrome c) assembly 1-like -4.75735
PYCR1 pyrroline-5-carboxylate reductase 1 -4.60585
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -4.5491
CD320 CD320 molecule -4.46375
RPS5 ribosomal protein S5 -4.4127
PGM1 phosphoglucomutase 1 -4.39195
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -4.1939
PSRC1 proline/serine-rich coiled-coil 1 -4.0108
LETMD1 LETM1 domain containing 1 -4.0053
MCM3 minichromosome maintenance complex component 3 -4.00095
CHMP4B charged multivesicular body protein 4B -3.99622
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.9295
INSIG1 insulin induced gene 1 -3.90283
HAUS4 HAUS augmin-like complex, subunit 4 -3.7943
TAC4 tachykinin 4 (hemokinin) -3.71575
RFC2 replication factor C (activator 1) 2, 40kDa -3.71287
TACC3 transforming, acidic coiled-coil containing protein 3 -3.70305
UQCRC1 ubiquinol-cytochrome c reductase core protein I -3.67425
MRPL58 mitochondrial ribosomal protein L58 -3.62485
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.61872
LBR lamin B receptor -3.59825
MCM5 minichromosome maintenance complex component 5 -3.5354
TSEN2 TSEN2 tRNA splicing endonuclease subunit -3.52825
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -3.5085
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 -3.50555
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -3.4584
CHAF1B chromatin assembly factor 1, subunit B (p60) -3.44285
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -3.44265
SNX6 sorting nexin 6 -3.4206
TCFL5 transcription factor-like 5 (basic helix-loop-helix) -3.4129
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) -3.4124
MRPS16 mitochondrial ribosomal protein S16 -3.3985
TUBG1 tubulin, gamma 1 -3.3749
MRPS7 mitochondrial ribosomal protein S7 -3.35405
MYG1 MYG1 exonuclease -3.30835
DDB2 damage-specific DNA binding protein 2, 48kDa -3.2914
FOXM1 forkhead box M1 -3.2907
TMEM94 transmembrane protein 94 -3.27795
POLE polymerase (DNA directed), epsilon, catalytic subunit -3.1855
ACAA1 acetyl-CoA acyltransferase 1 -3.17075
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 -3.159
TRAPPC12 trafficking protein particle complex 12 -3.14055
KIF20A kinesin family member 20A -3.1276
THYN1 thymocyte nuclear protein 1 -3.11415
SMC1A structural maintenance of chromosomes 1A -3.1089
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1 -3.1011
MTG1 mitochondrial ribosome-associated GTPase 1 -3.1007
KAT2A K(lysine) acetyltransferase 2A -3.0962
MRPS18B mitochondrial ribosomal protein S18B -3.09462
XPO1 exportin 1 -3.0874
ADAT1 adenosine deaminase, tRNA-specific 1 -3.04925
TOP2A topoisomerase (DNA) II alpha 170kDa -3.03142
TTC31 tetratricopeptide repeat domain 31 -3.00315
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -3.0008
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.99517
OXCT1 3-oxoacid CoA transferase 1 -2.9691
ACADVL acyl-CoA dehydrogenase, very long chain -2.9555
TRIM66 tripartite motif containing 66 -2.94235
CFP complement factor properdin -2.9329
CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 -2.93195
KIF15 kinesin family member 15 -2.92175
CSE1L CSE1 chromosome segregation 1-like (yeast) -2.88807
NT5C 5', 3'-nucleotidase, cytosolic -2.87795
PPARG peroxisome proliferator-activated receptor gamma -2.87165
PLK1 polo-like kinase 1 -2.86935
SORBS3 sorbin and SH3 domain containing 3 -2.86152
CDC20 cell division cycle 20 -2.8596
TEX264 testis expressed 264 -2.8589
EIF3D eukaryotic translation initiation factor 3, subunit D -2.839
ASF1B anti-silencing function 1B histone chaperone -2.8317
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 -2.825
RFWD3 ring finger and WD repeat domain 3 -2.81055
TCTA T-cell leukemia translocation altered -2.8037
TSC22D3 TSC22 domain family, member 3 -2.8003
KAT7 K(lysine) acetyltransferase 7 -2.79605
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative) -2.7945
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) -2.7927
POLD1 polymerase (DNA directed), delta 1, catalytic subunit -2.7892
KCTD2 potassium channel tetramerization domain containing 2 -2.78837
ACTMAP actin maturation protease -2.7786
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.77715
DONSON downstream neighbor of SON -2.74795
CS citrate synthase -2.733
FAM111A family with sequence similarity 111, member A -2.7282
ESD esterase D -2.7281
EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3 -2.7256
TCEAL4 transcription elongation factor A (SII)-like 4 -2.7243
EDNRB endothelin receptor type B -2.72232
CCNF cyclin F -2.7092
RALY RALY heterogeneous nuclear ribonucleoprotein -2.70875
DHRS11 dehydrogenase/reductase (SDR family) member 11 -2.70745
TNS2 tensin 2 -2.6995
MAP3K6 mitogen-activated protein kinase kinase kinase 6 -2.6893
FANCI Fanconi anemia, complementation group I -2.67613
APOLD1 apolipoprotein L domain containing 1 -2.67055
PHC1 polyhomeotic homolog 1 (Drosophila) -2.64615
STXBP2 syntaxin binding protein 2 -2.6322
AHCY adenosylhomocysteinase -2.6282
KIF4A kinesin family member 4A -2.62775
NTHL1 nth endonuclease III-like 1 (E. coli) -2.61135
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.59705
CDCA3 cell division cycle associated 3 -2.5855
HJURP Holliday junction recognition protein -2.5819
AARS1 alanyl-tRNA synthetase 1 -2.58055
RCC1L RCC1 like -2.5708
CD302 CD302 molecule -2.5705
CETN3 centrin, EF-hand protein, 3 -2.56405
NCAPG2 non-SMC condensin II complex, subunit G2 -2.5587
DDTL D-dopachrome tautomerase-like -2.55445
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 -2.5485
ACOT8 acyl-CoA thioesterase 8 -2.5476
QARS1 glutaminyl-tRNA synthetase 1 -2.5442
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.53015
PARN poly(A)-specific ribonuclease -2.52675
COPS7A COP9 signalosome subunit 7A -2.52075
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 -2.49935
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.4953
CYREN cell cycle regulator of NHEJ -2.4932
LAS1L LAS1-like (S. cerevisiae) -2.49055
CDCA8 cell division cycle associated 8 -2.4579
KYAT1 kynurenine aminotransferase 1 -2.45765
EIF4H eukaryotic translation initiation factor 4H -2.4473
CGGBP1 CGG triplet repeat binding protein 1 -2.4439
PIMREG PICALM interacting mitotic regulator -2.42965
TRIM9 tripartite motif containing 9 -2.4089
IMMT inner membrane protein, mitochondrial -2.4087
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like -2.4081
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G -2.404
MTIF2 mitochondrial translational initiation factor 2 -2.39065
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.38785
IGBP1 immunoglobulin (CD79A) binding protein 1 -2.38015
RPL3 ribosomal protein L3 -2.37776
LOC124907782 dual specificity protein phosphatase 22 -2.37625
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.3723
SPAG5 sperm associated antigen 5 -2.3704
CDT1 chromatin licensing and DNA replication factor 1 -2.36875
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 -2.36475
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.3618
AMZ2 archaelysin family metallopeptidase 2 -2.35065
NUP43 nucleoporin 43kDa -2.3504
PARP1 poly (ADP-ribose) polymerase 1 -2.34605
UCKL1 uridine-cytidine kinase 1-like 1 -2.346
CSK c-src tyrosine kinase -2.34575
KIFBP kinesin family binding protein -2.34475
DSN1 DSN1, MIS12 kinetochore complex component -2.34235
HMG20B high mobility group 20B -2.33873
GATD3 glutamine amidotransferase class 1 domain containing 3 -2.335
TCEA2 transcription elongation factor A (SII), 2 -2.33015
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.32905
TRAPPC4 trafficking protein particle complex 4 -2.32413
TTC12 tetratricopeptide repeat domain 12 -2.32065
GPS1 G protein pathway suppressor 1 -2.32055
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -2.3178
ATP5F1B ATP synthase F1 subunit beta -2.31505
EIF2D eukaryotic translation initiation factor 2D -2.31495
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) -2.31435
MCM7 minichromosome maintenance complex component 7 -2.30543
MAN2B1 mannosidase, alpha, class 2B, member 1 -2.30445
TIMP1 TIMP metallopeptidase inhibitor 1 -2.30275
GOLGA3 golgin A3 -2.29775
SH3BP1 SH3-domain binding protein 1 -2.2864
ICAM2 intercellular adhesion molecule 2 -2.27637
UBE2C ubiquitin-conjugating enzyme E2C -2.27275
ANKRD10 ankyrin repeat domain 10 -2.26795
MSH5 mutS homolog 5 -2.26735
ATP5PD ATP synthase peripheral stalk subunit d -2.26595
SNX17 sorting nexin 17 -2.265
TSPAN4 tetraspanin 4 -2.26248
LYRM1 LYR motif containing 1 -2.25985
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) -2.25855
CABIN1 calcineurin binding protein 1 -2.25147
FOXO4 forkhead box O4 -2.2494
CDC25B cell division cycle 25B -2.2458
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta -2.23915
UNG uracil-DNA glycosylase -2.2345
AAAS achalasia, adrenocortical insufficiency, alacrimia -2.2337
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.22705
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -2.22605
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.2257
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 -2.22225
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.21975
VILL villin-like -2.21735
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 -2.21055
TRIM24 tripartite motif containing 24 -2.19515
DENND5A DENN/MADD domain containing 5A -2.1931
TRIM68 tripartite motif containing 68 -2.1845
PPCDC phosphopantothenoylcysteine decarboxylase -2.18305
ACOD1 aconitate decarboxylase 1 -2.18215
TRIM6-TRIM34 TRIM6-TRIM34 readthrough -2.1789
CDC7 cell division cycle 7 -2.1735
PIGV phosphatidylinositol glycan anchor biosynthesis, class V -2.17215
NECAB3 N-terminal EF-hand calcium binding protein 3 -2.17095
CHAF1A chromatin assembly factor 1, subunit A (p150) -2.1664
CXCL5 chemokine (C-X-C motif) ligand 5 -2.16485
GTF3A general transcription factor IIIA -2.16243
SLC2A4RG SLC2A4 regulator -2.16055
CDK4 cyclin-dependent kinase 4 -2.15425
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha -2.1532
FASTKD5 FAST kinase domains 5 -2.152
GMPS guanine monphosphate synthase -2.14525
HMGB2 high mobility group box 2 -2.1349
CST3 cystatin C -2.1307
GID4 GID complex subunit 4 -2.12615
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -2.1258
TCOF1 Treacher Collins-Franceschetti syndrome 1 -2.12545
EIF4B eukaryotic translation initiation factor 4B -2.12357
ATRAID all-trans retinoic acid-induced differentiation factor -2.1185
TK2 thymidine kinase 2, mitochondrial -2.11817
LOC128966570 alpha-amylase 1B -2.1128
TJP2 tight junction protein 2 -2.10825
KLF11 Kruppel-like factor 11 -2.10665
RUVBL1 RuvB-like AAA ATPase 1 -2.10345
MCM4 minichromosome maintenance complex component 4 -2.10168
NBR1 neighbor of BRCA1 gene 1 -2.0999
BRCA1 breast cancer 1, early onset -2.09693
CDK1 cyclin-dependent kinase 1 -2.09083
YY1AP1 YY1 associated protein 1 -2.08895
ARMC6 armadillo repeat containing 6 -2.08455
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) -2.08415
ASL argininosuccinate lyase -2.0655
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 -2.05935
NEIL3 nei endonuclease VIII-like 3 (E. coli) -2.0494
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3 -2.0468
PEBP1 phosphatidylethanolamine binding protein 1 -2.0457
RPL10L ribosomal protein L10-like -2.04565
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase -2.043
CENPM centromere protein M -2.042
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 -2.0414
CCT7 chaperonin containing TCP1, subunit 7 (eta) -2.0404
RBM28 RNA binding motif protein 28 -2.0375
EXOSC8 exosome component 8 -2.0371
LOC112694756 uncharaterized LOC112694756 -2.0365
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 -2.03545
HIRIP3 HIRA interacting protein 3 -2.03435
GSTK1 glutathione S-transferase kappa 1 -2.0244
TCEAL1 transcription elongation factor A (SII)-like 1 -2.0213
DHX30 DEAH (Asp-Glu-Ala-His) box helicase 30 -2.01935
APEH acylaminoacyl-peptide hydrolase -2.0185
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 -2.015
SSBP1 single-stranded DNA binding protein 1, mitochondrial -2.01425
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 -2.0141
MUTYH mutY homolog -2.01365
REXO5 RNA exonuclease 5 -2.00848
DENR density-regulated protein -2.00545
MCM10 minichromosome maintenance complex component 10 -2.00515
COQ6 coenzyme Q6 monooxygenase -2.00465
KANSL1 KAT8 regulatory NSL complex subunit 1 -2.0032
RSAD1 radical S-adenosyl methionine domain containing 1 -2.002