CRCGN015_MCF10A.TP53.M_24H:P21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description spironolactone 11.24 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

693 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:P21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADGRE5 adhesion G protein-coupled receptor E5 5.9676
E2F2 E2F transcription factor 2 5.20675
UBQLN2 ubiquilin 2 5.1591
CNRIP1 cannabinoid receptor interacting protein 1 4.9811
PPARG peroxisome proliferator-activated receptor gamma 4.6949
MKNK1 MAP kinase interacting serine/threonine kinase 1 4.46695
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 4.0927
RAB31 RAB31, member RAS oncogene family 4.08225
H2BC12 H2B clustered histone 12 4.05812
ZFY zinc finger protein, Y-linked 4.0418
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 4.0162
KDM5D lysine (K)-specific demethylase 5D 3.90605
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 3.7915
DUSP14 dual specificity phosphatase 14 3.75285
TXNL4B thioredoxin-like 4B 3.72925
NLRP2B NLR family pyrin domain containing 2B 3.7032
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 3.68688
ZDHHC6 zinc finger, DHHC-type containing 6 3.529
FHL2 four and a half LIM domains 2 3.48585
WDR7 WD repeat domain 7 3.46585
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 3.44355
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX) 3.41765
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 3.41165
CASP8 caspase 8, apoptosis-related cysteine peptidase 3.3397
ZNF451 zinc finger protein 451 3.33037
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.30775
USP9Y ubiquitin specific peptidase 9, Y-linked 3.28522
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.264
PTPRJ protein tyrosine phosphatase, receptor type, J 3.2377
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.2333
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 3.20685
C8A complement component 8, alpha polypeptide 3.1444
SH3GL3 SH3-domain GRB2-like 3 3.1288
KLF8 Kruppel-like factor 8 3.1176
TMEM50A transmembrane protein 50A 3.0855
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 3.07465
ACAA1 acetyl-CoA acyltransferase 1 3.06493
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 3.04975
CFHR3 complement factor H-related 3 3.03065
WNT16 wingless-type MMTV integration site family, member 16 3.0193
PAX9 paired box 9 2.96225
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.953
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.9433
CRLF1 cytokine receptor-like factor 1 2.94135
NLGN4Y neuroligin 4, Y-linked 2.93425
CBLIF cobalamin binding intrinsic factor 2.90085
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit 2.89885
UBP1 upstream binding protein 1 (LBP-1a) 2.8977
LMOD1 leiomodin 1 (smooth muscle) 2.8795
DIO2 deiodinase, iodothyronine, type II 2.8676
LAG3 lymphocyte-activation gene 3 2.85365
HCFC2 host cell factor C2 2.8453
BRIX1 BRX1, biogenesis of ribosomes 2.8443
MTRF1L mitochondrial translational release factor 1-like 2.84005
CDKN2AIP CDKN2A interacting protein 2.83695
RIPPLY2-CYB5R4 RIPPLY2-CYB5R4 readthrough 2.83145
GPR22 G protein-coupled receptor 22 2.82835
HPR haptoglobin-related protein 2.81665
SH2D2A SH2 domain containing 2A 2.8162
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.80895
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 2.80655
TBPL1 TBP-like 1 2.8065
VCY1B variable charge, Y-linked 1B 2.8042
AMDHD2 amidohydrolase domain containing 2 2.80175
SLC30A10 solute carrier family 30, member 10 2.80105
ATP4B ATPase, H+/K+ exchanging, beta polypeptide 2.7983
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 2.783
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D 2.7711
TGM3 transglutaminase 3 2.76495
TESMIN testis expressed metallothionein like protein 2.7631
BHLHE40 basic helix-loop-helix family, member e40 2.7615
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.76082
HPGDS hematopoietic prostaglandin D synthase 2.756
CDH20 cadherin 20, type 2 2.75075
AFF4 AF4/FMR2 family, member 4 2.7496
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 2.74515
ZNF460 zinc finger protein 460 2.7448
MBNL3 muscleblind-like splicing regulator 3 2.7439
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 2.73252
RBMY1J RNA binding motif protein, Y-linked, family 1, member J 2.73245
ZNF480 zinc finger protein 480 2.7181
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 2.71105
RPH3A rabphilin 3A 2.70905
CFHR5 complement factor H-related 5 2.7088
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 2.7016
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 2.7003
HCRT hypocretin (orexin) neuropeptide precursor 2.69535
METTL16 methyltransferase like 16 2.6927
ECD ecdysoneless homolog (Drosophila) 2.69055
CPNE2 copine II 2.6811
IL12A interleukin 12A 2.6637
CDH18 cadherin 18, type 2 2.66085
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) 2.6556
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 2.65495
FPGT-TNNI3K FPGT-TNNI3K readthrough 2.6363
ANKRD34C ankyrin repeat domain 34C 2.62685
AKR1C4 aldo-keto reductase family 1, member C4 2.62565
H2BC11 H2B clustered histone 11 2.6159
CTLA4 cytotoxic T-lymphocyte-associated protein 4 2.6157
P2RY10 purinergic receptor P2Y, G-protein coupled, 10 2.6148
AKT2 v-akt murine thymoma viral oncogene homolog 2 2.6127
PLA2G15 phospholipase A2, group XV 2.6126
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 2.5968
TNIP3 TNFAIP3 interacting protein 3 2.5961
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 2.5956
H1-2 H1.2 linker histone, cluster member 2.59385
ADGRB1 adhesion G protein-coupled receptor B1 2.59235
LIPF lipase, gastric 2.591
CENPC centromere protein C 2.59045
ARL8B ADP-ribosylation factor-like 8B 2.587
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.5762
GRM1 glutamate receptor, metabotropic 1 2.57587
CCL16 chemokine (C-C motif) ligand 16 2.57475
NABP1 nucleic acid binding protein 1 2.5627
RAB27B RAB27B, member RAS oncogene family 2.5623
MED31 mediator complex subunit 31 2.5572
H2BC17 H2B clustered histone 17 2.5511
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 2.55
DOK2 docking protein 2, 56kDa 2.5493
IL2 interleukin 2 2.5479
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 2.54515
GTF2A2 general transcription factor IIA, 2, 12kDa 2.5381
TESPA1 thymocyte expressed, positive selection associated 1 2.5375
SNCB synuclein, beta 2.5329
RINT1 RAD50 interactor 1 2.5323
ICE1 interactor of little elongation complex ELL subunit 1 2.53175
EPB41 erythrocyte membrane protein band 4.1 2.53102
PDE12 phosphodiesterase 12 2.5258
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 2.5242
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 2.52075
VAV3 vav 3 guanine nucleotide exchange factor 2.5189
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 2.51485
EYA3 EYA transcriptional coactivator and phosphatase 3 2.5088
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 2.50875
DUOX2 dual oxidase 2 2.5087
EPN2 epsin 2 2.5077
FSTL4 follistatin-like 4 2.50525
ATG5 autophagy related 5 2.50293
VPS50 VPS50 subunit of EARP/GARPII complex 2.5016
PAQR5 progestin and adipoQ receptor family member V 2.4997
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 2.49515
CWF19L1 CWF19-like 1, cell cycle control (S. pombe) 2.4925
NYNRIN NYN domain and retroviral integrase containing 2.4915
BSN bassoon presynaptic cytomatrix protein 2.4889
ADTRP androgen-dependent TFPI-regulating protein 2.4882
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.4831
MTSS2 MTSS I-BAR domain containing 2 2.4778
FERRY3 FERRY endosomal RAB5 effector complex subunit 3 2.477
ADAM18 ADAM metallopeptidase domain 18 2.4763
PHKG1 phosphorylase kinase, gamma 1 (muscle) 2.4743
ACRV1 acrosomal vesicle protein 1 2.47347
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 2.4724
SSX1 synovial sarcoma, X breakpoint 1 2.4706
CUX2 cut-like homeobox 2 2.4697
SLC8A2 solute carrier family 8 (sodium/calcium exchanger), member 2 2.46955
KLRD1 killer cell lectin-like receptor subfamily D, member 1 2.4678
PRAMEF26 PRAME family member 26 2.4664
C18ORF25 chromosome 18 open reading frame 25 2.46365
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 2.46245
ZNF571 zinc finger protein 571 2.46
MASP2 mannan-binding lectin serine peptidase 2 2.45743
KLRC4 killer cell lectin-like receptor subfamily C, member 4 2.4553
H2BC9 H2B clustered histone 9 2.4541
MPV17L-BMERB1 MPV17L-BMERB1 readthrough 2.4539
MRPL44 mitochondrial ribosomal protein L44 2.4526
CRTAM cytotoxic and regulatory T cell molecule 2.45025
COL4A1 collagen, type IV, alpha 1 2.4497
MORC1 MORC family CW-type zinc finger 1 2.44705
CCDC177 coiled-coil domain containing 177 2.44535
MDM4 MDM4, p53 regulator 2.4452
TSPY2 testis specific protein, Y-linked 2 2.44093
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A 2.4391
OR1G1 olfactory receptor, family 1, subfamily G, member 1 2.4387
LBX1 ladybird homeobox 1 2.43785
ZNF254 zinc finger protein 254 2.43745
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 2.437
TEF thyrotrophic embryonic factor 2.43505
WDR4 WD repeat domain 4 2.43195
MCPH1 microcephalin 1 2.4279
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 2.42315
CMTR1 cap methyltransferase 1 2.4202
FRS2 fibroblast growth factor receptor substrate 2 2.4185
OR7C1 olfactory receptor, family 7, subfamily C, member 1 2.41315
SHH sonic hedgehog 2.40965
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 2.40925
H2AC19 H2A clustered histone 19 2.40887
KATNBL1 katanin p80 subunit B-like 1 2.4079
SPICE1 spindle and centriole associated protein 1 2.4034
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 2.4009
C8B complement component 8, beta polypeptide 2.4006
CASS4 Cas scaffolding protein family member 4 2.3996
TACR2 tachykinin receptor 2 2.3963
ANTXR1 anthrax toxin receptor 1 2.3956
RSU1 Ras suppressor protein 1 2.39485
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I 2.39325
TAS2R13 taste receptor, type 2, member 13 2.39075
TRPM2 transient receptor potential cation channel, subfamily M, member 2 2.38815
ZNF280A zinc finger protein 280A 2.38555
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 2.38235
PADI3 peptidyl arginine deiminase, type III 2.38145
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1 2.3812
HRK harakiri, BCL2 interacting protein 2.36865
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 2.3685
TBX21 T-box 21 2.36605
QSER1 glutamine and serine rich 1 2.36595
IL17F interleukin 17F 2.36375
ZNF37A zinc finger protein 37A 2.36
ERN1 endoplasmic reticulum to nucleus signaling 1 2.35675
FRG1 FSHD region gene 1 2.3563
DENND2B DENN domain containing 2B 2.353
GPR25 G protein-coupled receptor 25 2.35145
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 2.3514
SLC67A2 solute carrier family 67 member 2 2.34955
YME1L1 YME1-like 1 ATPase 2.34942
MSTN myostatin 2.34605
PYCR3 pyrroline-5-carboxylate reductase 3 2.34435
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2 2.34075
ZNF407 zinc finger protein 407 2.33943
NTN1 netrin 1 2.3359
EPHA4 EPH receptor A4 2.33385
SRRM5 serine/arginine repetitive matrix 5 2.33378
KMT2D lysine (K)-specific methyltransferase 2D 2.33205
COL19A1 collagen, type XIX, alpha 1 2.329
CD8B CD8b molecule 2.3288
POU3F4 POU class 3 homeobox 4 2.3286
HBB hemoglobin, beta 2.32628
LY6G5C lymphocyte antigen 6 complex, locus G5C 2.3219
ASB4 ankyrin repeat and SOCS box containing 4 2.31862
TSPAN2 tetraspanin 2 2.31845
NEK11 NIMA-related kinase 11 2.31605
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast) 2.31558
TMEM151B transmembrane protein 151B 2.31253
CTNNA3 catenin (cadherin-associated protein), alpha 3 2.3124
MELTF melanotransferrin 2.3102
TLK2 tousled-like kinase 2 2.30895
IFT54 intraflagellar transport 54 2.30685
BARX2 BARX homeobox 2 2.3064
NTSR2 neurotensin receptor 2 2.30585
SP4 Sp4 transcription factor 2.30455
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 2.30255
PKP3 plakophilin 3 2.29745
ANKRD37 ankyrin repeat domain 37 2.29315
CLUL1 clusterin-like 1 (retinal) 2.29135
CD58 CD58 molecule 2.29087
IRS4 insulin receptor substrate 4 2.29025
DUSP21 dual specificity phosphatase 21 2.2888
TSKU tsukushi, small leucine rich proteoglycan 2.2881
AGBL3 ATP/GTP binding protein-like 3 2.28355
MAGEC2 melanoma antigen family C2 2.28255
CD33 CD33 molecule 2.2816
DNAAF8 dynein axonemal assembly factor 8 2.2815
TENM1 teneurin transmembrane protein 1 2.28135
LRRTM2 leucine rich repeat transmembrane neuronal 2 2.28055
CRYBA4 crystallin, beta A4 2.27945
APOC2 apolipoprotein C-II 2.27877
SIDT1 SID1 transmembrane family, member 1 2.27715
GBP1 guanylate binding protein 1, interferon-inducible 2.27653
TMLHE trimethyllysine hydroxylase, epsilon 2.27645
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein 2.2763
CUL2 cullin 2 2.27607
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 2.2758
NR2C2 nuclear receptor subfamily 2, group C, member 2 2.2742
CBLN1 cerebellin 1 precursor 2.2734
LOC100996750 keratin-associated protein 4-7 2.27085
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta 2.26815
ZNF507 zinc finger protein 507 2.2662
STYK1 serine/threonine/tyrosine kinase 1 2.26505
TLR6 toll-like receptor 6 2.26035
CRHR2 corticotropin releasing hormone receptor 2 2.26012
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 2.26008
ZKSCAN8 zinc finger with KRAB and SCAN domains 8 2.2595
TRMT61B tRNA methyltransferase 61B 2.2593
PLAAT2 phospholipase A and acyltransferase 2 2.2585
SAGE1 sarcoma antigen 1 2.2575
IBSP integrin-binding sialoprotein 2.25625
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 2.25465
LNPEP leucyl/cystinyl aminopeptidase 2.25415
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 2.2538
AFF3 AF4/FMR2 family, member 3 2.25252
TNRC6B trinucleotide repeat containing 6B 2.24815
FBXL2 F-box and leucine-rich repeat protein 2 2.2451
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled 2.24495
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 2.24385
PGM5 phosphoglucomutase 5 2.2432
MCF2L2 MCF.2 cell line derived transforming sequence-like 2 2.2418
CSF1 colony stimulating factor 1 (macrophage) 2.24074
CCL5 chemokine (C-C motif) ligand 5 2.24058
ACKR2 atypical chemokine receptor 2 2.2394
LCN1 lipocalin 1 2.238
TBR1 T-box, brain, 1 2.23495
NEUROD2 neuronal differentiation 2 2.23455
FAT1 FAT atypical cadherin 1 2.23125
KRT36 keratin 36, type I 2.23125
F2RL2 coagulation factor II (thrombin) receptor-like 2 2.23065
MTMR7 myotubularin related protein 7 2.22965
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) 2.22925
XCR1 chemokine (C motif) receptor 1 2.2282
KNL1 kinetochore scaffold 1 2.22365
JPH2 junctophilin 2 2.22095
NUP88 nucleoporin 88kDa 2.21815
YTHDC2 YTH domain containing 2 2.21725
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 2.21705
MRM3 mitochondrial rRNA methyltransferase 3 2.2149
ZNF675 zinc finger protein 675 2.21375
LMTK2 lemur tyrosine kinase 2 2.21315
FASTKD2 FAST kinase domains 2 2.21128
FEZF2 FEZ family zinc finger 2 2.21065
IKZF2 IKAROS family zinc finger 2 (Helios) 2.20975
RFX3 regulatory factor X, 3 (influences HLA class II expression) 2.2084
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 2.20805
OR2S2 olfactory receptor, family 2, subfamily S, member 2 (gene/pseudogene) 2.2076
FOXE3 forkhead box E3 2.20685
AMELX amelogenin, X-linked 2.2066
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 2.2046
ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8 2.204
TLL1 tolloid-like 1 2.20375
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 2.20314
IKZF3 IKAROS family zinc finger 3 (Aiolos) 2.20285
FAM3C family with sequence similarity 3, member C 2.20205
TBX5 T-box 5 2.19933
SNAI1 snail family zinc finger 1 2.19875
LGALS12 lectin, galactoside-binding, soluble, 12 2.198
RASA3 RAS p21 protein activator 3 2.19777
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 2.1977
TEX12 testis expressed 12 2.19705
ATOH1 atonal homolog 1 (Drosophila) 2.19635
TMEM242 transmembrane protein 242 2.19555
FAAP20 FA core complex associated protein 20 2.19435
AKR1D1 aldo-keto reductase family 1, member D1 2.19435
KRT38 keratin 38, type I 2.1943
APOL1 apolipoprotein L, 1 2.19355
GJA5 gap junction protein, alpha 5, 40kDa 2.1928
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 2.19185
OR12D3 olfactory receptor, family 12, subfamily D, member 3 2.1917
NPVF neuropeptide VF precursor 2.1908
THPO thrombopoietin 2.19007
RAB21 RAB21, member RAS oncogene family 2.1884
CXCL11 chemokine (C-X-C motif) ligand 11 2.1866
PARP11 poly (ADP-ribose) polymerase family, member 11 2.18575
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) 2.18545
FAM135A family with sequence similarity 135, member A 2.1842
CT55 cancer/testis antigen 55 2.18185
SEC14L4 SEC14-like 4 (S. cerevisiae) 2.18085
MTPAP mitochondrial poly(A) polymerase 2.17995
PRKCE protein kinase C, epsilon 2.1796
NEMF nuclear export mediator factor 2.17725
FOXF1 forkhead box F1 2.17725
OVOL3 ovo-like zinc finger 3 2.17675
CYTH4 cytohesin 4 2.17653
AKAP5 A kinase (PRKA) anchor protein 5 2.17315
DLGAP2 discs, large (Drosophila) homolog-associated protein 2 2.1726
ADAM20 ADAM metallopeptidase domain 20 2.1724
PRPF18 pre-mRNA processing factor 18 2.1717
ASCC3 activating signal cointegrator 1 complex subunit 3 2.17055
FOXA2 forkhead box A2 2.1697
MEPE matrix extracellular phosphoglycoprotein 2.1693
TEC tec protein tyrosine kinase 2.16875
GFRA4 GDNF family receptor alpha 4 2.1685
CCL7 chemokine (C-C motif) ligand 7 2.1674
MC3R melanocortin 3 receptor 2.16685
CREB1 cAMP responsive element binding protein 1 2.16436
USP3 ubiquitin specific peptidase 3 2.1641
GADD45G growth arrest and DNA-damage-inducible, gamma 2.1641
FOXN2 forkhead box N2 2.16315
DLX6 distal-less homeobox 6 2.16105
BCL2 B-cell CLL/lymphoma 2 2.16072
TMOD3 tropomodulin 3 (ubiquitous) 2.15805
KRTAP1-3 keratin associated protein 1-3 2.158
SPRING1 SREBF pathway regulator in golgi 1 2.15715
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase 2.1568
LATS1 large tumor suppressor kinase 1 2.1557
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 2.1547
BTBD3 BTB (POZ) domain containing 3 2.15205
NKX6-1 NK6 homeobox 1 2.1514
MORC3 MORC family CW-type zinc finger 3 2.15115
GCM2 glial cells missing homolog 2 (Drosophila) 2.15015
KLHL26 kelch-like family member 26 2.14985
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 2.14952
TTPA tocopherol (alpha) transfer protein 2.14895
IRF1 interferon regulatory factor 1 2.14695
TLE2 transducin-like enhancer of split 2 2.14637
KCTD20 potassium channel tetramerization domain containing 20 2.1451
NPY2R neuropeptide Y receptor Y2 2.14473
GLP2R glucagon-like peptide 2 receptor 2.1447
ADGRL1 adhesion G protein-coupled receptor L1 2.14402
COL4A6 collagen, type IV, alpha 6 2.13915
CDY1 chromodomain protein, Y-linked, 1 2.13858
KIAA0408 KIAA0408 2.13785
FSHR follicle stimulating hormone receptor 2.13675
PPP1R3A protein phosphatase 1, regulatory subunit 3A 2.1337
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.13235
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 2.13175
S100A5 S100 calcium binding protein A5 2.1302
PURG purine-rich element binding protein G 2.12845
INSL6 insulin-like 6 2.12825
ITGB7 integrin, beta 7 2.1263
NSUN7 NOP2/Sun domain family, member 7 2.1253
ACSM1 acyl-CoA synthetase medium-chain family member 1 2.125
DRD5 dopamine receptor D5 2.12475
BFSP2 beaded filament structural protein 2, phakinin 2.1242
EFNA2 ephrin-A2 2.12415
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1 2.12253
OR2J3 olfactory receptor, family 2, subfamily J, member 3 2.1219
PACC1 proton activated chloride channel 1 2.12045
FAM204A family with sequence similarity 204, member A 2.1194
SETMAR SET domain and mariner transposase fusion gene 2.1188
DCHS2 dachsous cadherin-related 2 2.1186
TRPC5 transient receptor potential cation channel, subfamily C, member 5 2.1182
DNAH6 dynein, axonemal, heavy chain 6 2.11775
CABP5 calcium binding protein 5 2.11775
TRIM25 tripartite motif containing 25 2.11755
ZNF585B zinc finger protein 585B 2.1175
CDH8 cadherin 8, type 2 2.11692
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 2.1142
EN2 engrailed homeobox 2 2.1139
OVOL1 ovo-like zinc finger 1 2.11245
DCAF17 DDB1 and CUL4 associated factor 17 2.11155
KRTAP9-9 keratin associated protein 9-9 2.11075
MBL2 mannose-binding lectin (protein C) 2, soluble 2.1098
TSPAN6 tetraspanin 6 2.10843
PRKG2 protein kinase, cGMP-dependent, type II 2.10835
PPIC peptidylprolyl isomerase C (cyclophilin C) 2.10785
PCYT1A phosphate cytidylyltransferase 1, choline, alpha 2.1061
PCDH17 protocadherin 17 2.10585
SOSTDC1 sclerostin domain containing 1 2.1048
PAX6 paired box 6 2.10435
ZNF780B zinc finger protein 780B 2.1042
TRMT9B tRNA methyltransferase 9B (putative) 2.104
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 2.10345
LGALS1 lectin, galactoside-binding, soluble, 1 2.10295
SLCO2A1 solute carrier organic anion transporter family, member 2A1 2.10175
OR52A1 olfactory receptor, family 52, subfamily A, member 1 2.1017
MRPL19 mitochondrial ribosomal protein L19 2.10065
NPPB natriuretic peptide B 2.1003
FAM13C family with sequence similarity 13, member C 2.1
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 2.09998
IFNA5 interferon, alpha 5 2.0997
PRLR prolactin receptor 2.09874
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 2.0973
SPO11 SPO11 meiotic protein covalently bound to DSB 2.09725
HCRTR1 hypocretin (orexin) receptor 1 2.09685
DNAH3 dynein, axonemal, heavy chain 3 2.09545
PLA2G2F phospholipase A2, group IIF 2.09485
CHRM3 cholinergic receptor, muscarinic 3 2.0941
LINS1 lines homolog 1 2.09395
GJB4 gap junction protein, beta 4, 30.3kDa 2.09375
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 2.0936
ASIC2 acid sensing (proton gated) ion channel 2 2.09325
OTUD7B OTU deubiquitinase 7B 2.09295
ISCA1 iron-sulfur cluster assembly 1 2.09222
EFR3B EFR3 homolog B (S. cerevisiae) 2.0918
NKX3-2 NK3 homeobox 2 2.0909
SPRYD7 SPRY domain containing 7 2.0906
TMOD2 tropomodulin 2 (neuronal) 2.09045
ZBTB33 zinc finger and BTB domain containing 33 2.08975
CD84 CD84 molecule 2.08948
IL21R interleukin 21 receptor 2.0888
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 2.0874
TTC22 tetratricopeptide repeat domain 22 2.08592
SLC25A30 solute carrier family 25, member 30 2.08585
ANKRD40CL ANKRD40 C-terminal like 2.0849
RASSF9 Ras association (RalGDS/AF-6) domain family (N-terminal) member 9 2.0846
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 2.0843
BRDT bromodomain, testis-specific 2.08335
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 2.08255
ADGB androglobin 2.08235
SLC22A14 solute carrier family 22, member 14 2.08165
KANSL3 KAT8 regulatory NSL complex subunit 3 2.07965
HES2 hes family bHLH transcription factor 2 2.07792
TFDP3 transcription factor Dp family, member 3 2.07635
LIM2 lens intrinsic membrane protein 2, 19kDa 2.0742
FRS3 fibroblast growth factor receptor substrate 3 2.07405
ZXDA zinc finger, X-linked, duplicated A 2.07393
CHD6 chromodomain helicase DNA binding protein 6 2.07328
ZNF821 zinc finger protein 821 2.06958
ANAPC2 anaphase promoting complex subunit 2 2.06895
SIRT4 sirtuin 4 2.06835
CIBAR1 CBY1 interacting BAR domain containing 1 2.06695
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase) 2.0654
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 2.0652
CYLC2 cylicin, basic protein of sperm head cytoskeleton 2 2.063
TMEM259 transmembrane protein 259 2.06202
BRD9 bromodomain containing 9 2.06095
ATP8B3 ATPase, aminophospholipid transporter, class I, type 8B, member 3 2.05925
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 2.05915
OMP olfactory marker protein 2.05845
BCHE butyrylcholinesterase 2.0584
VSX1 visual system homeobox 1 2.05755
RSC1A1 regulatory solute carrier protein, family 1, member 1 2.05663
CAMK4 calcium/calmodulin-dependent protein kinase IV 2.05645
CRYBA1 crystallin, beta A1 2.0564
CPED1 cadherin-like and PC-esterase domain containing 1 2.0542
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 2.0539
FRMPD4 FERM and PDZ domain containing 4 2.05375
GLRA2 glycine receptor, alpha 2 2.0521
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 2.05155
MAP3K14 mitogen-activated protein kinase kinase kinase 14 2.0514
INSL5 insulin-like 5 2.05135
MSRA methionine sulfoxide reductase A 2.05125
E4F1 E4F transcription factor 1 2.05075
SOCS4 suppressor of cytokine signaling 4 2.05045
TSPO2 translocator protein 2 2.0497
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1 2.04705
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 2.0465
GRM2 glutamate receptor, metabotropic 2 2.04555
CCDC70 coiled-coil domain containing 70 2.0454
PCIF1 PDX1 C-terminal inhibiting factor 1 2.04496
OR2F2 olfactory receptor, family 2, subfamily F, member 2 2.04405
HBE1 hemoglobin, epsilon 1 2.0437
PDHX pyruvate dehydrogenase complex, component X 2.04342
TJP1 tight junction protein 1 2.04318
CNTN6 contactin 6 2.0426
PAPOLB poly(A) polymerase beta (testis specific) 2.0426
FGF12 fibroblast growth factor 12 2.0423
RERE arginine-glutamic acid dipeptide (RE) repeats 2.04205
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.04163
TSSK2 testis-specific serine kinase 2 2.0414
CNKSR2 connector enhancer of kinase suppressor of Ras 2 2.04095
CFAP43 cilia and flagella associated protein 43 2.0405
IFNG interferon, gamma 2.04035
PRDM13 PR domain containing 13 2.04
MCHR1 melanin-concentrating hormone receptor 1 2.03935
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 2.03825
FBXO40 F-box protein 40 2.03765
AMELY amelogenin, Y-linked 2.0375
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.03735
GCLC glutamate-cysteine ligase, catalytic subunit 2.03725
ZNF141 zinc finger protein 141 2.03705
KISS1 KiSS-1 metastasis-suppressor 2.03705
ZER1 zyg-11 related, cell cycle regulator 2.0366
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.0365
IFT22 intraflagellar transport 22 2.03395
CLDN14 claudin 14 2.0338
PKD2L2 polycystic kidney disease 2-like 2 2.03295
NOX3 NADPH oxidase 3 2.03105
FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase) 2.03075
HPD 4-hydroxyphenylpyruvate dioxygenase 2.0279
CKB creatine kinase, brain 2.0274
KPNA5 karyopherin alpha 5 (importin alpha 6) 2.02615
SLC6A16 solute carrier family 6, member 16 2.0256
CCNT2 cyclin T2 2.02498
PHEX phosphate regulating endopeptidase homolog, X-linked 2.02475
ENDOU endonuclease, polyU-specific 2.0246
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 2.02305
LRRC40 leucine rich repeat containing 40 2.02155
CD6 CD6 molecule 2.02108
OR5I1 olfactory receptor, family 5, subfamily I, member 1 2.02105
SH3GLB2 SH3-domain GRB2-like endophilin B2 2.0202
RXFP3 relaxin/insulin-like family peptide receptor 3 2.01945
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 2.0194
SIX2 SIX homeobox 2 2.019
F13B coagulation factor XIII, B polypeptide 2.01875
BZW2 basic leucine zipper and W2 domains 2 2.0185
IL4 interleukin 4 2.01543
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 2.0152
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 2.01505
YAF2 YY1 associated factor 2 2.0147
PBOV1 prostate and breast cancer overexpressed 1 2.01455
IL15RA interleukin 15 receptor, alpha 2.01395
GNLY granulysin 2.01363
TAS2R4 taste receptor, type 2, member 4 2.0128
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 2.01233
RAB30 RAB30, member RAS oncogene family 2.0096
GHR growth hormone receptor 2.0088
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2 2.00865
PRAMEF10 PRAME family member 10 2.0079
FOXL1 forkhead box L1 2.00715
CETN2 centrin, EF-hand protein, 2 2.00625
DPF3 D4, zinc and double PHD fingers, family 3 2.00525
NEUROD1 neuronal differentiation 1 2.00495
CST8 cystatin 8 (cystatin-related epididymal specific) 2.0039
ZNF556 zinc finger protein 556 2.00285
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 2.00085

decreased expression

Symbol Name Standardized Value
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -8.68093
DDIT4 DNA-damage-inducible transcript 4 -6.91765
VAT1 vesicle amine transport 1 -5.6745
NLRP4 NLR family, pyrin domain containing 4 -5.54245
CDK4 cyclin-dependent kinase 4 -4.5278
CHMP4B charged multivesicular body protein 4B -4.40793
CCDC86 coiled-coil domain containing 86 -4.18015
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -4.11465
UFM1 ubiquitin-fold modifier 1 -4.05455
PCCB propionyl CoA carboxylase, beta polypeptide -3.68145
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.6632
SMC1A structural maintenance of chromosomes 1A -3.65395
CDC45 cell division cycle 45 -3.566
HADH hydroxyacyl-CoA dehydrogenase -3.48048
PUDP pseudouridine 5'-phosphatase -3.45175
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.41165
UBE2C ubiquitin-conjugating enzyme E2C -3.395
PLK1 polo-like kinase 1 -3.35635
DDB2 damage-specific DNA binding protein 2, 48kDa -3.33055
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -3.30335
ADD3 adducin 3 (gamma) -3.27623
GFUS GDP-L-fucose synthase -3.26128
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -3.2229
STXBP2 syntaxin binding protein 2 -3.15385
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -3.1229
TSPAN3 tetraspanin 3 -3.05325
PIGP phosphatidylinositol glycan anchor biosynthesis, class P -3.03165
KIFBP kinesin family binding protein -3.02885
PDZD8 PDZ domain containing 8 -2.9883
SGK1 serum/glucocorticoid regulated kinase 1 -2.98455
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) -2.96985
EXOSC8 exosome component 8 -2.91915
ACOD1 aconitate decarboxylase 1 -2.8839
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) -2.864
NUP93 nucleoporin 93kDa -2.8249
SERINC5 serine incorporator 5 -2.8043
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.77075
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.74855
TFDP1 transcription factor Dp-1 -2.74357
TM9SF2 transmembrane 9 superfamily member 2 -2.73585
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.71815
TCFL5 transcription factor-like 5 (basic helix-loop-helix) -2.6685
MKNK2 MAP kinase interacting serine/threonine kinase 2 -2.6391
RUVBL1 RuvB-like AAA ATPase 1 -2.63205
INTS3 integrator complex subunit 3 -2.6169
PHKG2 phosphorylase kinase, gamma 2 (testis) -2.5725
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.5525
LOC112694756 uncharaterized LOC112694756 -2.51953
GRN granulin -2.51137
CDC20 cell division cycle 20 -2.50515
MRPS33 mitochondrial ribosomal protein S33 -2.49655
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.496
ACOT8 acyl-CoA thioesterase 8 -2.4894
THYN1 thymocyte nuclear protein 1 -2.4758
HSPA1A heat shock 70kDa protein 1A -2.475
EBNA1BP2 EBNA1 binding protein 2 -2.46925
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 -2.46295
POM121C POM121 transmembrane nucleoporin C -2.45878
RPS5 ribosomal protein S5 -2.4586
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase -2.4509
INSIG1 insulin induced gene 1 -2.44063
TCEA2 transcription elongation factor A (SII), 2 -2.43985
UBA1 ubiquitin-like modifier activating enzyme 1 -2.4332
LBR lamin B receptor -2.4283
ENTREP3 endosomal transmembrane epsin interactor 3 -2.38713
ADAT1 adenosine deaminase, tRNA-specific 1 -2.36725
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 -2.36275
PROSER1 proline and serine rich 1 -2.33525
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa -2.3151
PGM1 phosphoglucomutase 1 -2.3101
ETFB electron-transfer-flavoprotein, beta polypeptide -2.3097
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.28755
GNG5 guanine nucleotide binding protein (G protein), gamma 5 -2.28665
ARHGAP19 Rho GTPase activating protein 19 -2.28585
ZC3H4 zinc finger CCCH-type containing 4 -2.27415
WASHC3 WASH complex subunit 3 -2.269
THAP4 THAP domain containing 4 -2.26265
ARID4A AT rich interactive domain 4A (RBP1-like) -2.26235
GSTZ1 glutathione S-transferase zeta 1 -2.25035
TXLNA taxilin alpha -2.23965
TOMM34 translocase of outer mitochondrial membrane 34 -2.22715
MRPS18B mitochondrial ribosomal protein S18B -2.22158
ZXDC ZXD family zinc finger C -2.21515
ESD esterase D -2.20202
PPCS phosphopantothenoylcysteine synthetase -2.20195
CD302 CD302 molecule -2.1964
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 -2.1857
NANS N-acetylneuraminic acid synthase -2.18155
PGLS 6-phosphogluconolactonase -2.17812
CANT1 calcium activated nucleotidase 1 -2.17793
RPN1 ribophorin I -2.1686
RCN3 reticulocalbin 3, EF-hand calcium binding domain -2.14337
CXCL2 chemokine (C-X-C motif) ligand 2 -2.13505
MUS81 MUS81 structure-specific endonuclease subunit -2.13415
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.12083
SYBU syntabulin (syntaxin-interacting) -2.12065
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -2.1146
HIRIP3 HIRA interacting protein 3 -2.09985
SNX6 sorting nexin 6 -2.0973
STEAP3 STEAP family member 3, metalloreductase -2.0971
NUDC nudC nuclear distribution protein -2.09348
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa -2.09205
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 -2.08858
MRPS31 mitochondrial ribosomal protein S31 -2.07245
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -2.0665
SPAG7 sperm associated antigen 7 -2.06345
FTO fat mass and obesity associated -2.06215
NGRN neugrin, neurite outgrowth associated -2.0574
ACTMAP actin maturation protease -2.0571
NCAPG2 non-SMC condensin II complex, subunit G2 -2.04725
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -2.03685
ELOF1 elongation factor 1 homolog (S. cerevisiae) -2.0344
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1 -2.02505
CDCA8 cell division cycle associated 8 -2.02235
EIF3CL eukaryotic translation initiation factor 3, subunit C-like -2.01787
MPZL1 myelin protein zero-like 1 -2.01516
KIF2C kinesin family member 2C -2.01345
EMC9 ER membrane protein complex subunit 9 -2.01335
FAM114A2 family with sequence similarity 114, member A2 -2.0014
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -2.00045