CRCGN015_MCF10A.TP53.M_24H:P23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dibenzo[a,h]pyrene 33.49 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

199 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:P23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CNRIP1 cannabinoid receptor interacting protein 1 9.25535
AMDHD2 amidohydrolase domain containing 2 5.9104
CXCR4 chemokine (C-X-C motif) receptor 4 5.28753
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 5.17675
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 5.10535
KIF5C kinesin family member 5C 4.86483
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 4.65095
SPTAN1 spectrin, alpha, non-erythrocytic 1 4.5105
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 4.36048
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 4.1476
TBX2 T-box 2 4.14093
BDH1 3-hydroxybutyrate dehydrogenase, type 1 4.12325
GRB10 growth factor receptor-bound protein 10 3.81872
HDGFL3 HDGF like 3 3.59009
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 3.5517
ZNF205 zinc finger protein 205 3.48645
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.45295
MORN1 MORN repeat containing 1 3.39405
EFNB1 ephrin-B1 3.20405
ADRB2 adrenoceptor beta 2, surface 3.2039
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific 3.16515
ALDOC aldolase C, fructose-bisphosphate 3.14555
VRTN vertebrae development associated 3.1031
SCT secretin 3.09875
GPR20 G protein-coupled receptor 20 3.02745
PRKCD protein kinase C, delta 3.00665
LOC124907090 ankyrin repeat domain-containing protein SOWAHC-like 2.9153
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 2.8789
ISCU iron-sulfur cluster assembly enzyme 2.8101
AKAP8L A kinase (PRKA) anchor protein 8-like 2.75088
RFX5 regulatory factor X, 5 (influences HLA class II expression) 2.74378
DUX4 double homeobox 4 2.73625
DENND2D DENN/MADD domain containing 2D 2.71395
AGR2 anterior gradient 2 2.7037
HOXC4 homeobox C4 2.6777
VCX3A variable charge, X-linked 3A 2.65992
PTP4A3 protein tyrosine phosphatase type IVA, member 3 2.6248
DTX2 deltex 2, E3 ubiquitin ligase 2.58
TOM1L1 target of myb1 (chicken)-like 1 2.56195
SAMD14 sterile alpha motif domain containing 14 2.55785
POLL polymerase (DNA directed), lambda 2.55775
PCYT2 phosphate cytidylyltransferase 2, ethanolamine 2.53265
RHBG Rh family, B glycoprotein (gene/pseudogene) 2.5074
PDCD1 programmed cell death 1 2.50335
BIRC7 baculoviral IAP repeat containing 7 2.50295
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F 2.4668
INPP1 inositol polyphosphate-1-phosphatase 2.4521
BCL7B B-cell CLL/lymphoma 7B 2.4503
SLC26A1 solute carrier family 26 (anion exchanger), member 1 2.43195
SPTBN2 spectrin, beta, non-erythrocytic 2 2.42385
JMJD7 jumonji domain containing 7 2.40135
COQ4 coenzyme Q4 2.39245
CYTH3 cytohesin 3 2.39195
ZBTB32 zinc finger and BTB domain containing 32 2.37535
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) 2.3727
IL13 interleukin 13 2.36975
LOC124907012 endogenous retrovirus group K member 7 Env polyprotein-like 2.3663
MNMIP1 manchette microtubule inner protein 1 2.3523
MATN4 matrilin 4 2.33435
UNC5B unc-5 homolog B (C. elegans) 2.33362
PRM2 protamine 2 2.3308
NT5C 5', 3'-nucleotidase, cytosolic 2.3174
PKD2L1 polycystic kidney disease 2-like 1 2.29375
EBF2 early B-cell factor 2 2.28745
CHN1 chimerin 1 2.26465
OSGIN1 oxidative stress induced growth inhibitor 1 2.25515
RAB40C RAB40C, member RAS oncogene family 2.23195
A4GALT alpha 1,4-galactosyltransferase 2.23105
NCK1 NCK adaptor protein 1 2.22517
TP53TG5 TP53 target 5 2.213
ACAD10 acyl-CoA dehydrogenase family, member 10 2.2041
SNCG synuclein, gamma (breast cancer-specific protein 1) 2.1925
GALP galanin-like peptide 2.1918
MAP1S microtubule-associated protein 1S 2.19135
PCDHB12 protocadherin beta 12 2.1903
PKD1 polycystic kidney disease 1 (autosomal dominant) 2.18622
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2 2.1846
PARD6A par-6 family cell polarity regulator alpha 2.184
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 2.1727
HR hair growth associated 2.16885
RAB3A RAB3A, member RAS oncogene family 2.1613
LAMC3 laminin, gamma 3 2.1598
MBNL3 muscleblind-like splicing regulator 3 2.1581
CREG1 cellular repressor of E1A-stimulated genes 1 2.1538
IPO8 importin 8 2.15085
ADGRG2 adhesion G protein-coupled receptor G2 2.14725
TRIM25 tripartite motif containing 25 2.1471
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 2.14552
PCDHB13 protocadherin beta 13 2.1409
PHF13 PHD finger protein 13 2.1347
UBA1 ubiquitin-like modifier activating enzyme 1 2.13435
PHOX2A paired-like homeobox 2a 2.1241
CNTFR ciliary neurotrophic factor receptor 2.1209
ADGRB1 adhesion G protein-coupled receptor B1 2.1203
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.10985
IL23A interleukin 23, alpha subunit p19 2.1074
TSR3 TSR3, 20S rRNA accumulation, homolog (S. cerevisiae) 2.09567
PRDM1 PR domain containing 1, with ZNF domain 2.0914
IFT57 intraflagellar transport 57 2.08555
CBX8 chromobox homolog 8 2.07895
GDAP1L1 ganglioside induced differentiation associated protein 1-like 1 2.0786
TOLLIP toll interacting protein 2.06465
LAMA5 laminin, alpha 5 2.05815
LOC105379278 uncharacterized LOC105379278 2.03785
NDN necdin, melanoma antigen (MAGE) family member 2.03345
IQSEC3 IQ motif and Sec7 domain 3 2.0326
ATOX1 antioxidant 1 copper chaperone 2.02905
KLHL36 kelch-like family member 36 2.02705
CATSPERZ catsper channel auxiliary subunit zeta 2.0233
OLFML2B olfactomedin-like 2B 2.02215
DEF6 differentially expressed in FDCP 6 homolog (mouse) 2.0183
LOC124908558 X antigen family member 1-like 2.01475
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 2.0116
KANK2 KN motif and ankyrin repeat domains 2 2.0028

decreased expression

Symbol Name Standardized Value
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -5.93075
CDC25B cell division cycle 25B -5.627
PCNA proliferating cell nuclear antigen -5.0
BASP1 brain abundant, membrane attached signal protein 1 -4.7295
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -4.7151
BAG3 BCL2-associated athanogene 3 -4.55415
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.53535
TMEM230 transmembrane protein 230 -4.45615
CD320 CD320 molecule -4.4352
DDRGK1 DDRGK domain containing 1 -4.137
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -3.94445
PSIP1 PC4 and SFRS1 interacting protein 1 -3.72967
NSFL1C NSFL1 (p97) cofactor (p47) -3.7086
AP5S1 adaptor-related protein complex 5, sigma 1 subunit -3.4481
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -3.36982
MKKS McKusick-Kaufman syndrome -3.3192
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) -3.2901
SGK1 serum/glucocorticoid regulated kinase 1 -3.1848
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase -3.15765
PANK2 pantothenate kinase 2 -3.1461
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 -3.1203
CENPB centromere protein B, 80kDa -3.11455
MAVS mitochondrial antiviral signaling protein -3.09115
CRNKL1 crooked neck pre-mRNA splicing factor 1 -3.03885
SNX5 sorting nexin 5 -3.02275
SNRPB2 small nuclear ribonucleoprotein polypeptide B -3.0196
CELF2 CUGBP, Elav-like family member 2 -3.01055
S100A8 S100 calcium binding protein A8 -2.98935
TIMP1 TIMP metallopeptidase inhibitor 1 -2.97805
BTBD3 BTB (POZ) domain containing 3 -2.8463
KDM3A lysine (K)-specific demethylase 3A -2.79425
UBOX5 U-box domain containing 5 -2.78043
VLDLR very low density lipoprotein receptor -2.68105
TCEAL4 transcription elongation factor A (SII)-like 4 -2.66975
HSPA1A heat shock 70kDa protein 1A -2.6639
KIF16B kinesin family member 16B -2.6361
TSPAN5 tetraspanin 5 -2.6251
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -2.607
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.57695
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.51102
PLCB4 phospholipase C, beta 4 -2.4802
KRT14 keratin 14, type I -2.47065
DOCK1 dedicator of cytokinesis 1 -2.46255
NXT1 nuclear transport factor 2-like export factor 1 -2.4419
NOP56 NOP56 ribonucleoprotein -2.44025
SEC23B Sec23 homolog B (S. cerevisiae) -2.41475
GOLGA7 golgin A7 -2.40725
SELENOW selenoprotein W -2.396
PADI2 peptidyl arginine deiminase, type II -2.39335
SNCA synuclein, alpha (non A4 component of amyloid precursor) -2.37983
FOXJ2 forkhead box J2 -2.3795
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.3726
RNASE4 ribonuclease, RNase A family, 4 -2.36605
PLPBP pyridoxal phosphate binding protein -2.36442
RRBP1 ribosome binding protein 1 -2.34736
BPHL biphenyl hydrolase-like (serine hydrolase) -2.3424
RGS2 regulator of G-protein signaling 2 -2.33935
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -2.33325
PRPS2 phosphoribosyl pyrophosphate synthetase 2 -2.3166
RECK reversion-inducing-cysteine-rich protein with kazal motifs -2.3029
QSOX1 quiescin Q6 sulfhydryl oxidase 1 -2.2959
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) -2.2891
NCALD neurocalcin delta -2.23195
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative) -2.225
ANXA1 annexin A1 -2.196
BNC2 basonuclin 2 -2.18165
MTUS1 microtubule associated tumor suppressor 1 -2.17528
DSTN destrin (actin depolymerizing factor) -2.16325
HLA-E major histocompatibility complex, class I, E -2.15173
ZNF133 zinc finger protein 133 -2.13022
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 -2.11825
ZSCAN26 zinc finger and SCAN domain containing 26 -2.109
FKBP1C FK506 binding protein 1C -2.08652
NMRK1 nicotinamide riboside kinase 1 -2.0846
IFITM1 interferon induced transmembrane protein 1 -2.0815
ATRN attractin -2.06725
TGOLN2 trans-golgi network protein 2 -2.05825
ZNF337 zinc finger protein 337 -2.0472
TRIM68 tripartite motif containing 68 -2.04605
HBG1 hemoglobin, gamma A -2.04585
PSG6 pregnancy specific beta-1-glycoprotein 6 -2.03685
S100A7 S100 calcium binding protein A7 -2.0319
COG7 component of oligomeric golgi complex 7 -2.03035
PPP4C protein phosphatase 4, catalytic subunit -2.0222
EIF3G eukaryotic translation initiation factor 3, subunit G -2.00975