CRCGN015_MCF10A.TP53.M_24H:P24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dibenzo[a,h]pyrene 11.16 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

281 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:P24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
KIF5C kinesin family member 5C 5.63785
C2CD2 C2 calcium-dependent domain containing 2 5.15455
GADD45A growth arrest and DNA-damage-inducible, alpha 5.113
MAMLD1 mastermind-like domain containing 1 4.7529
METRN meteorin, glial cell differentiation regulator 4.39185
CAPN1 calpain 1, (mu/I) large subunit 4.1804
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 4.10845
ARID5B AT rich interactive domain 5B (MRF1-like) 4.0757
COMP cartilage oligomeric matrix protein 3.8945
VAV3 vav 3 guanine nucleotide exchange factor 3.84683
ALAS1 5'-aminolevulinate synthase 1 3.66935
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 3.6097
PTK2B protein tyrosine kinase 2 beta 3.48408
CCDC106 coiled-coil domain containing 106 3.357
STIMATE STIM activating enhancer 3.265
GHR growth hormone receptor 3.1676
MUC16 mucin 16, cell surface associated 3.13955
GARRE1 granule associated Rac and RHOG effector 1 3.1196
MUC1 mucin 1, cell surface associated 3.1187
SMIM40 small integral membrane protein 40 3.09815
CD2AP CD2-associated protein 2.996
HTRA1 HtrA serine peptidase 1 2.9398
MPC2 mitochondrial pyruvate carrier 2 2.8398
TRAPPC6A trafficking protein particle complex 6A 2.8378
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 2.83705
APH1A APH1A gamma secretase subunit 2.7989
IGHMBP2 immunoglobulin mu binding protein 2 2.79295
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 2.7835
CTSD cathepsin D 2.7508
SGMS1 sphingomyelin synthase 1 2.7347
SLC61A1 solute carrier family 61 member 1 2.7307
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 2.70675
SLC39A7 solute carrier family 39 (zinc transporter), member 7 2.6666
C5 complement component 5 2.6654
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 2.65415
NOSIP nitric oxide synthase interacting protein 2.6478
PHF13 PHD finger protein 13 2.6458
CFAP69 cilia and flagella associated protein 69 2.62915
SCGB2A1 secretoglobin, family 2A, member 1 2.6226
ARL4C ADP-ribosylation factor-like 4C 2.62237
PDLIM1 PDZ and LIM domain 1 2.6164
MNS1 meiosis-specific nuclear structural 1 2.60865
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa 2.59345
DENND2D DENN/MADD domain containing 2D 2.5933
STAG3 stromal antigen 3 2.5718
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 2.5714
TTC12 tetratricopeptide repeat domain 12 2.5636
RTN1 reticulon 1 2.55662
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 2.5475
LEFTY1 left-right determination factor 1 2.54695
LILRB5 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5 2.5463
PLCH2 phospholipase C, eta 2 2.54345
RAI2 retinoic acid induced 2 2.54035
RESF1 retroelement silencing factor 1 2.53305
FGFR4 fibroblast growth factor receptor 4 2.51237
PDCD1 programmed cell death 1 2.50225
NELL2 NEL-like 2 (chicken) 2.49335
ZNF813 zinc finger protein 813 2.4844
ADORA2A adenosine A2a receptor 2.4711
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 2.44945
MEST mesoderm specific transcript 2.4061
NAXD NAD(P)HX dehydratase 2.3696
PSENEN presenilin enhancer gamma secretase subunit 2.3681
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.3676
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 2.3654
EMC10 ER membrane protein complex subunit 10 2.35905
OSGIN1 oxidative stress induced growth inhibitor 1 2.34875
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2.34483
ZNF613 zinc finger protein 613 2.3437
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.334
DEF8 differentially expressed in FDCP 8 homolog (mouse) 2.3204
GCHFR GTP cyclohydrolase I feedback regulator 2.3164
EML3 echinoderm microtubule associated protein like 3 2.31345
LRRC49 leucine rich repeat containing 49 2.30645
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2.3062
ZBTB3 zinc finger and BTB domain containing 3 2.3045
TRIM13 tripartite motif containing 13 2.3037
ICAM1 intercellular adhesion molecule 1 2.29867
DOCK4 dedicator of cytokinesis 4 2.2913
STMN4 stathmin-like 4 2.28595
STX4 syntaxin 4 2.28365
LYN LYN proto-oncogene, Src family tyrosine kinase 2.28302
ZBTB39 zinc finger and BTB domain containing 39 2.28295
ECM2 extracellular matrix protein 2, female organ and adipocyte specific 2.28195
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 2.27635
SOX2 SRY (sex determining region Y)-box 2 2.27603
AEBP1 AE binding protein 1 2.2699
CLXN calaxin 2.26785
EPS8L1 EPS8-like 1 2.26206
RAG1 recombination activating gene 1 2.25745
GHSR growth hormone secretagogue receptor 2.2543
ZKSCAN4 zinc finger with KRAB and SCAN domains 4 2.2532
ANTKMT adenine nucleotide translocase lysine methyltransferase 2.2476
BTBD2 BTB (POZ) domain containing 2 2.2469
OGN osteoglycin 2.24245
MARCHF2 membrane associated ring-CH-type finger 2 2.2411
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.23195
ZNF205 zinc finger protein 205 2.2281
LZTS3 leucine zipper, putative tumor suppressor family member 3 2.22735
ZNF350 zinc finger protein 350 2.22515
THSD7A thrombospondin, type I, domain containing 7A 2.22355
AHNAK2 AHNAK nucleoprotein 2 2.22145
CHD9NB CHD9 neighbor 2.21995
TERT telomerase reverse transcriptase 2.2049
ADGRB2 adhesion G protein-coupled receptor B2 2.20345
VTCN1 V-set domain containing T cell activation inhibitor 1 2.1998
POMK protein-O-mannose kinase 2.19395
RIMS1 regulating synaptic membrane exocytosis 1 2.1876
DCAF15 DDB1 and CUL4 associated factor 15 2.18678
EMILIN2 elastin microfibril interfacer 2 2.18525
MAPK10 mitogen-activated protein kinase 10 2.1784
STMN2 stathmin 2 2.1766
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 2.17555
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5 2.17405
IL1R1 interleukin 1 receptor, type I 2.1651
LRFN3 leucine rich repeat and fibronectin type III domain containing 3 2.1614
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa 2.16128
MMP2 matrix metallopeptidase 2 2.16045
CFAP45 cilia and flagella associated protein 45 2.16005
CASP6 caspase 6, apoptosis-related cysteine peptidase 2.15315
GFI1B growth factor independent 1B transcription repressor 2.15165
GPR63 G protein-coupled receptor 63 2.14715
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.1442
PALM paralemmin 2.13975
CTBP2 C-terminal binding protein 2 2.1317
PLAAT2 phospholipase A and acyltransferase 2 2.1298
DRC8 dynein regulatory complex subunit 8 2.12675
IFNAR1 interferon (alpha, beta and omega) receptor 1 2.1241
DRC3 dynein regulatory complex subunit 3 2.12275
GAS6 growth arrest-specific 6 2.11705
TRIM39-RPP21 TRIM39-RPP21 readthrough 2.1159
AMH anti-Mullerian hormone 2.1151
SSTR3 somatostatin receptor 3 2.113
ASRGL1 asparaginase like 1 2.11035
DNAI1 dynein, axonemal, intermediate chain 1 2.1089
PARD6A par-6 family cell polarity regulator alpha 2.10585
LOXL1 lysyl oxidase-like 1 2.1027
FAM107A family with sequence similarity 107, member A 2.10087
CMKLR1 chemerin chemokine-like receptor 1 2.09877
TPRA1 transmembrane protein, adipocyte asscociated 1 2.09745
TES testin LIM domain protein 2.09613
FILIP1L filamin A interacting protein 1-like 2.0939
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit 2.09225
PCDHGA11 protocadherin gamma subfamily A, 11 2.08885
IFT54 intraflagellar transport 54 2.08765
TNNT1 troponin T type 1 (skeletal, slow) 2.08325
CFHR5 complement factor H-related 5 2.08065
CSNK2B casein kinase 2, beta polypeptide 2.0757
FGF7 fibroblast growth factor 7 2.0712
EPHA3 EPH receptor A3 2.06983
NPR1 natriuretic peptide receptor 1 2.06983
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) 2.06925
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B 2.0669
PKD2L1 polycystic kidney disease 2-like 1 2.06685
NTSR1 neurotensin receptor 1 (high affinity) 2.0668
LRRK1 leucine-rich repeat kinase 1 2.06455
EMP2 epithelial membrane protein 2 2.06215
PID1 phosphotyrosine interaction domain containing 1 2.06145
KLF13 Kruppel-like factor 13 2.06055
OPRD1 opioid receptor, delta 1 2.05645
CLIP2 CAP-GLY domain containing linker protein 2 2.0534
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 2.0475
ZC3H3 zinc finger CCCH-type containing 3 2.0463
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 2.0462
ATRNL1 attractin-like 1 2.0416
CDCP1 CUB domain containing protein 1 2.03865
SOCS2 suppressor of cytokine signaling 2 2.03647
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 2.0362
ANKH ANKH inorganic pyrophosphate transport regulator 2.03405
FCHO1 FCH domain only 1 2.03365
ZNF787 zinc finger protein 787 2.0333
SOX17 SRY (sex determining region Y)-box 17 2.0312
TPD52L2 tumor protein D52-like 2 2.027
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 2.02555
CLCN2 chloride channel, voltage-sensitive 2 2.02235
DPP4 dipeptidyl-peptidase 4 2.02038
ZNF423 zinc finger protein 423 2.01755
KLC3 kinesin light chain 3 2.0152
SPON1 spondin 1, extracellular matrix protein 2.01476
TEX14 testis expressed 14 2.01215
ANXA1 annexin A1 2.0121
ZSCAN9 zinc finger and SCAN domain containing 9 2.0087
PEX11A peroxisomal biogenesis factor 11 alpha 2.00747
RAB11FIP2 RAB11 family interacting protein 2 (class I) 2.00565
NLGN4X neuroligin 4, X-linked 2.00385
FKBPL FK506 binding protein like 2.00235
KCNK10 potassium channel, two pore domain subfamily K, member 10 2.00225
TWSG1 twisted gastrulation BMP signaling modulator 1 2.00185
HOOK1 hook microtubule-tethering protein 1 2.00135
FRMD4A FERM domain containing 4A 2.00055

decreased expression

Symbol Name Standardized Value
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.75135
COG4 component of oligomeric golgi complex 4 -4.4984
TCTA T-cell leukemia translocation altered -4.40345
JMJD6 jumonji domain containing 6 -4.235
TOPBP1 topoisomerase (DNA) II binding protein 1 -4.19545
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.73195
COTL1 coactosin-like F-actin binding protein 1 -3.62295
LOC112694756 uncharaterized LOC112694756 -3.17995
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -3.0139
CD320 CD320 molecule -2.98745
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.9788
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -2.95985
MRPS33 mitochondrial ribosomal protein S33 -2.94985
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha -2.94462
CORO1A coronin, actin binding protein, 1A -2.92385
VEGFC vascular endothelial growth factor C -2.9061
NEK7 NIMA-related kinase 7 -2.879
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.8693
RGS2 regulator of G-protein signaling 2 -2.86855
LAGE3 L antigen family, member 3 -2.86345
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 -2.85955
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.85795
MXRA7 matrix-remodelling associated 7 -2.83835
LDHD lactate dehydrogenase D -2.77195
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.77085
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.73275
ARFIP2 ADP-ribosylation factor interacting protein 2 -2.72675
KIF14 kinesin family member 14 -2.6812
BCAS3 breast carcinoma amplified sequence 3 -2.67775
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa -2.66065
MUL1 mitochondrial E3 ubiquitin protein ligase 1 -2.652
HACD1 3-hydroxyacyl-CoA dehydratase 1 -2.61455
PEF1 penta-EF-hand domain containing 1 -2.5921
PGM1 phosphoglucomutase 1 -2.5728
BATF basic leucine zipper transcription factor, ATF-like -2.5703
SLC35H1 solute carrier family 35 member H1 -2.5245
ATP5PD ATP synthase peripheral stalk subunit d -2.52325
MSL2 male-specific lethal 2 homolog (Drosophila) -2.5027
TMPRSS11D transmembrane protease, serine 11D -2.4633
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 -2.46325
HELZ helicase with zinc finger -2.44425
INTS3 integrator complex subunit 3 -2.4303
SMCO4 single-pass membrane protein with coiled-coil domains 4 -2.3896
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.3821
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -2.36065
CBR3 carbonyl reductase 3 -2.33695
GALE UDP-galactose-4-epimerase -2.3263
CASC3 cancer susceptibility candidate 3 -2.3083
RPA3 replication protein A3, 14kDa -2.30445
CSK c-src tyrosine kinase -2.2799
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -2.2368
XPO6 exportin 6 -2.23517
AURKA aurora kinase A -2.23443
FASTKD5 FAST kinase domains 5 -2.2158
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.21065
MIA melanoma inhibitory activity -2.2064
DIABLO diablo, IAP-binding mitochondrial protein -2.2012
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.1897
EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3 -2.1806
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -2.1795
CHPT1 choline phosphotransferase 1 -2.16965
ACY1 aminoacylase 1 -2.1639
NFIL3 nuclear factor, interleukin 3 regulated -2.1567
MPHOSPH8 M-phase phosphoprotein 8 -2.13875
ZDHHC18 zinc finger, DHHC-type containing 18 -2.13445
ZBTB11 zinc finger and BTB domain containing 11 -2.12595
TM9SF3 transmembrane 9 superfamily member 3 -2.1233
TOMM34 translocase of outer mitochondrial membrane 34 -2.1219
LRRC20 leucine rich repeat containing 20 -2.12165
HLA-A major histocompatibility complex, class I, A -2.11815
SECISBP2 SECIS binding protein 2 -2.10665
ARMCX3 armadillo repeat containing, X-linked 3 -2.106
TSKU tsukushi, small leucine rich proteoglycan -2.10035
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) -2.09755
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 -2.0748
DARS1 aspartyl-tRNA synthetase 1 -2.0742
LOC128125814 uncharacterized LOC128125814 -2.06405
UBE3C ubiquitin protein ligase E3C -2.0595
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha -2.0557
ILK integrin-linked kinase -2.03785
ROPN1B rhophilin associated tail protein 1B -2.029
OXCT1 3-oxoacid CoA transferase 1 -2.02815
PHKB phosphorylase kinase, beta -2.02568
PHB1 prohibitin 1 -2.01737
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -2.0168
TAC4 tachykinin 4 (hemokinin) -2.01265
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.0118
FBXL4 F-box and leucine-rich repeat protein 4 -2.01095
CASKIN2 CASK interacting protein 2 -2.00235
PRRX2 paired related homeobox 2 -2.00205
RNF114 ring finger protein 114 -2.00028