CRCGN015_MCF10A.WT.HP_24H:A03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

61 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:A03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ZW10 zw10 kinetochore protein 5.10686
COMP cartilage oligomeric matrix protein 4.49576
MAP7 microtubule-associated protein 7 4.49183
PRR7 proline rich 7 (synaptic) 3.54872
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.32913
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.97142
CHMP6 charged multivesicular body protein 6 2.76041
GADD45A growth arrest and DNA-damage-inducible, alpha 2.63422
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.53983
LGMN legumain 2.38872
BLMH bleomycin hydrolase 2.35244
BCL7A B-cell CLL/lymphoma 7A 2.34114
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.33231
DDR1 discoidin domain receptor tyrosine kinase 1 2.28317
LYN LYN proto-oncogene, Src family tyrosine kinase 2.25262
GHR growth hormone receptor 2.23179
MOK MOK protein kinase 2.22509
ANKRD10 ankyrin repeat domain 10 2.2249
TXLNA taxilin alpha 2.21676
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.1647
LOXL1 lysyl oxidase-like 1 2.09614
SPINT1 serine peptidase inhibitor, Kunitz type 1 2.07794
INTS15 integrator complex subunit 15 2.06852
CLDN7 claudin 7 2.06427
AEBP1 AE binding protein 1 2.06116
HBA1 hemoglobin, alpha 1 2.0587
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 2.04601
CAPN1 calpain 1, (mu/I) large subunit 2.04031
PDGFRL platelet-derived growth factor receptor-like 2.0348
NOSIP nitric oxide synthase interacting protein 2.0226
CLN3 ceroid-lipofuscinosis, neuronal 3 2.01718

decreased expression

Symbol Name Standardized Value
NUP85 nucleoporin 85kDa -4.93091
CDC45 cell division cycle 45 -4.53192
KDM3A lysine (K)-specific demethylase 3A -4.19432
COG2 component of oligomeric golgi complex 2 -4.1476
MRPS7 mitochondrial ribosomal protein S7 -3.9391
MRPL58 mitochondrial ribosomal protein L58 -3.76268
SAP30BP SAP30 binding protein -3.48696
TIMP1 TIMP metallopeptidase inhibitor 1 -3.48479
GNPAT glyceronephosphate O-acyltransferase -3.3545
KIF20A kinesin family member 20A -3.11954
RBM34 RNA binding motif protein 34 -3.00836
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.79691
SCYL3 SCY1-like 3 (S. cerevisiae) -2.76211
JPT1 Jupiter microtubule associated homolog 1 -2.5
CBR3 carbonyl reductase 3 -2.48654
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.41995
CARMIL1 capping protein regulator and myosin 1 linker 1 -2.34737
GRB2 growth factor receptor-bound protein 2 -2.18961
ATP5PD ATP synthase peripheral stalk subunit d -2.17409
PIBF1 progesterone immunomodulatory binding factor 1 -2.17027
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -2.15335
TRIM9 tripartite motif containing 9 -2.15215
FERRY3 FERRY endosomal RAB5 effector complex subunit 3 -2.14677
FOSL1 FOS-like antigen 1 -2.11754
ACOX1 acyl-CoA oxidase 1, palmitoyl -2.11133
USP21 ubiquitin specific peptidase 21 -2.1033
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.0646
PRR16 proline rich 16 -2.05961
LLGL2 lethal giant larvae homolog 2 (Drosophila) -2.05067
EXO1 exonuclease 1 -2.04473