CRCGN015_MCF10A.WT.HP_24H:A07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description potassium 1h-indol-3-yl sulfate 104.28 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

264 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:A07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HMOX1 heme oxygenase 1 9.66613
TXNRD1 thioredoxin reductase 1 7.29846
IL1B interleukin 1, beta 6.25568
CTSL cathepsin L 6.07524
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 5.57398
SQSTM1 sequestosome 1 5.31967
UGDH UDP-glucose 6-dehydrogenase 5.27322
CXCL2 chemokine (C-X-C motif) ligand 2 5.20088
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 5.18886
GLRX glutaredoxin (thioltransferase) 5.14843
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 4.96856
PHGDH phosphoglycerate dehydrogenase 4.63838
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 4.60596
DENND2D DENN/MADD domain containing 2D 4.54202
PYCR1 pyrroline-5-carboxylate reductase 1 4.30015
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.14887
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.11631
SQOR sulfide quinone oxidoreductase 3.87899
IER3 immediate early response 3 3.82328
GARS1 glycyl-tRNA synthetase 1 3.81808
LPGAT1 lysophosphatidylglycerol acyltransferase 1 3.79651
ASNS asparagine synthetase (glutamine-hydrolyzing) 3.75577
AGR2 anterior gradient 2 3.64607
MYLK myosin light chain kinase 3.63349
AARS1 alanyl-tRNA synthetase 1 3.62913
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 3.58572
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.55754
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 3.54265
TNIP1 TNFAIP3 interacting protein 1 3.51044
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 3.49317
RAP1GAP RAP1 GTPase activating protein 3.20991
CXCR4 chemokine (C-X-C motif) receptor 4 3.17297
LRP10 low density lipoprotein receptor-related protein 10 3.15508
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 3.14612
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 3.12941
NRIP1 nuclear receptor interacting protein 1 3.12357
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 3.0778
CBR1 carbonyl reductase 1 3.05649
PSAT1 phosphoserine aminotransferase 1 3.04437
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.01377
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3.00962
TXLNA taxilin alpha 2.98575
TRIM16 tripartite motif containing 16 2.98487
ALAS1 5'-aminolevulinate synthase 1 2.89237
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.88202
BCL7B B-cell CLL/lymphoma 7B 2.86967
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) 2.86028
CEMIP2 cell migration inducing hyaluronidase 2 2.82066
YARS1 tyrosyl-tRNA synthetase 1 2.77523
NCK2 NCK adaptor protein 2 2.75299
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.727
DUSP5 dual specificity phosphatase 5 2.70472
S100P S100 calcium binding protein P 2.70342
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.70004
CDC25B cell division cycle 25B 2.69405
DUSP4 dual specificity phosphatase 4 2.60673
UBQLN2 ubiquilin 2 2.59248
STXBP1 syntaxin binding protein 1 2.57998
NQO1 NAD(P)H dehydrogenase, quinone 1 2.53264
RRAGC Ras-related GTP binding C 2.52823
DDA1 DET1 and DDB1 associated 1 2.49254
VAT1 vesicle amine transport 1 2.4752
KEAP1 kelch-like ECH-associated protein 1 2.46607
IL1A interleukin 1, alpha 2.41717
TWF2 twinfilin actin binding protein 2 2.41126
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.39228
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 2.36847
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G 2.36023
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 2.34836
TPD52L2 tumor protein D52-like 2 2.34204
NARS1 asparaginyl-tRNA synthetase 1 2.32179
ADAM10 ADAM metallopeptidase domain 10 2.3138
GPX2 glutathione peroxidase 2 2.31063
LOC128125814 uncharacterized LOC128125814 2.29901
KMT5B lysine methyltransferase 5B 2.29293
TM9SF3 transmembrane 9 superfamily member 3 2.28319
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.27959
MAT2A methionine adenosyltransferase II, alpha 2.27162
VPREB1 pre-B lymphocyte 1 2.26575
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.25652
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 2.24271
ZMPSTE24 zinc metallopeptidase STE24 2.24129
KIF5C kinesin family member 5C 2.22286
NDEL1 nudE neurodevelopment protein 1-like 1 2.22258
RPN1 ribophorin I 2.19915
EML3 echinoderm microtubule associated protein like 3 2.17538
AEN apoptosis enhancing nuclease 2.16699
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.16627
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 2.16592
RPP38 ribonuclease P/MRP 38kDa subunit 2.16534
GALE UDP-galactose-4-epimerase 2.16322
SKIC2 SKI2 subunit of superkiller complex 2.16154
MBD1 methyl-CpG binding domain protein 1 2.15552
KCTD5 potassium channel tetramerization domain containing 5 2.15259
MVP major vault protein 2.15098
ECM1 extracellular matrix protein 1 2.15026
TLCD3A TLC domain containing 3A 2.14345
FHL2 four and a half LIM domains 2 2.14017
IRF9 interferon regulatory factor 9 2.13944
ELOVL1 ELOVL fatty acid elongase 1 2.13847
DENND5A DENN/MADD domain containing 5A 2.13534
HEXB hexosaminidase B (beta polypeptide) 2.12849
AKR1C3 aldo-keto reductase family 1, member C3 2.12367
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 2.11236
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 2.08889
GCLM glutamate-cysteine ligase, modifier subunit 2.08066
GTPBP2 GTP binding protein 2 2.07629
RCN1 reticulocalbin 1, EF-hand calcium binding domain 2.07198
TARS1 threonyl-tRNA synthetase 1 2.04238
ADGRE5 adhesion G protein-coupled receptor E5 2.03056
PPP1R15A protein phosphatase 1, regulatory subunit 15A 2.02618
ZBTB20 zinc finger and BTB domain containing 20 2.02261
RYBP RING1 and YY1 binding protein 2.01224

decreased expression

Symbol Name Standardized Value
PCCB propionyl CoA carboxylase, beta polypeptide -5.85225
CCNB2 cyclin B2 -4.74966
PSRC1 proline/serine-rich coiled-coil 1 -4.74153
STMN1 stathmin 1 -4.3495
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.29724
TOP2A topoisomerase (DNA) II alpha 170kDa -4.25023
MRPS7 mitochondrial ribosomal protein S7 -4.23152
NUP85 nucleoporin 85kDa -3.91651
NCAPD2 non-SMC condensin I complex, subunit D2 -3.79458
CDK1 cyclin-dependent kinase 1 -3.65367
UBE2C ubiquitin-conjugating enzyme E2C -3.6415
GOLT1B golgi transport 1B -3.49563
GADD45B growth arrest and DNA-damage-inducible, beta -3.48876
SESN1 sestrin 1 -3.40815
HAT1 histone acetyltransferase 1 -3.37995
PRR15L proline rich 15-like -3.33807
BIRC5 baculoviral IAP repeat containing 5 -3.31881
ALDOC aldolase C, fructose-bisphosphate -3.30923
PRCP prolylcarboxypeptidase (angiotensinase C) -3.16932
NT5DC2 5'-nucleotidase domain containing 2 -3.10657
KIF20A kinesin family member 20A -3.04685
ADI1 acireductone dioxygenase 1 -2.99032
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.94806
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.91886
MTFR1 mitochondrial fission regulator 1 -2.89603
CCNA2 cyclin A2 -2.88157
PEX2 peroxisomal biogenesis factor 2 -2.87708
AURKA aurora kinase A -2.86833
OXCT1 3-oxoacid CoA transferase 1 -2.84723
NUSAP1 nucleolar and spindle associated protein 1 -2.83839
LHX2 LIM homeobox 2 -2.79501
FKBP5 FK506 binding protein 5 -2.75497
MRPL58 mitochondrial ribosomal protein L58 -2.75008
BID BH3 interacting domain death agonist -2.73462
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.71167
SOSTDC1 sclerostin domain containing 1 -2.64146
THAP11 THAP domain containing 11 -2.62308
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.60578
CDC25C cell division cycle 25C -2.60284
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 -2.60284
KLHDC2 kelch domain containing 2 -2.58273
ARHGAP15 Rho GTPase activating protein 15 -2.5746
CDCA3 cell division cycle associated 3 -2.5666
COQ3 coenzyme Q3 methyltransferase -2.56113
SUMO4 small ubiquitin-like modifier 4 -2.53406
MECR mitochondrial trans-2-enoyl-CoA reductase -2.52129
NUP133 nucleoporin 133kDa -2.51089
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae) -2.49635
TSPAN6 tetraspanin 6 -2.49603
PARPBP PARP1 binding protein -2.49426
MED21 mediator complex subunit 21 -2.43953
TMEM160 transmembrane protein 160 -2.43157
NIPSNAP1 nipsnap homolog 1 (C. elegans) -2.42082
GTF2A2 general transcription factor IIA, 2, 12kDa -2.41764
NPDC1 neural proliferation, differentiation and control, 1 -2.41008
EBAG9 estrogen receptor binding site associated, antigen, 9 -2.40896
PRELID3B PRELI domain containing 3B -2.40405
PTMS parathymosin -2.39875
RFC3 replication factor C (activator 1) 3, 38kDa -2.39317
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa -2.38564
CLCNKA chloride channel, voltage-sensitive Ka -2.38025
TP53 tumor protein p53 -2.3794
HADH hydroxyacyl-CoA dehydrogenase -2.3661
S100A4 S100 calcium binding protein A4 -2.36569
SAP30BP SAP30 binding protein -2.3654
HEATR1 HEAT repeat containing 1 -2.36112
EAPP E2F-associated phosphoprotein -2.35002
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 -2.34239
KIF11 kinesin family member 11 -2.33937
IPO8 importin 8 -2.33173
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.32947
ARMC7 armadillo repeat containing 7 -2.3275
CT55 cancer/testis antigen 55 -2.32708
ATP8B4 ATPase, class I, type 8B, member 4 -2.32061
TRAP1 TNF receptor-associated protein 1 -2.32061
PPP1R13L protein phosphatase 1, regulatory subunit 13 like -2.31542
OIP5 Opa interacting protein 5 -2.31077
CDC23 cell division cycle 23 -2.30784
RPA3 replication protein A3, 14kDa -2.30471
SPC25 SPC25, NDC80 kinetochore complex component -2.30252
BTNL3 butyrophilin-like 3 -2.29523
CFHR2 complement factor H-related 2 -2.28395
GPN3 GPN-loop GTPase 3 -2.2807
RAD51AP1 RAD51 associated protein 1 -2.27548
MTREX Mtr4 exosome RNA helicase -2.27124
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.25565
EVL Enah/Vasp-like -2.23947
NUP37 nucleoporin 37kDa -2.23546
KCTD20 potassium channel tetramerization domain containing 20 -2.23441
EMC2 ER membrane protein complex subunit 2 -2.22988
CDC40 cell division cycle 40 -2.21543
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.2145
GPR87 G protein-coupled receptor 87 -2.21145
RAD21 RAD21 homolog (S. pombe) -2.21002
LDHD lactate dehydrogenase D -2.20371
ZNF16 zinc finger protein 16 -2.20336
SP8 Sp8 transcription factor -2.19269
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.1918
RAB3D RAB3D, member RAS oncogene family -2.18362
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 -2.18327
SMC4 structural maintenance of chromosomes 4 -2.18018
ATG5 autophagy related 5 -2.1774
CLDN8 claudin 8 -2.1767
CCNB1 cyclin B1 -2.17497
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.16698
LARP7 La ribonucleoprotein domain family, member 7 -2.15796
HOXC8 homeobox C8 -2.13746
PYCR3 pyrroline-5-carboxylate reductase 3 -2.1366
ADGRL3 adhesion G protein-coupled receptor L3 -2.132
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -2.13128
LRRC40 leucine rich repeat containing 40 -2.12008
DPF1 D4, zinc and double PHD fingers family 1 -2.1198
F2R coagulation factor II (thrombin) receptor -2.11796
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.09855
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) -2.09434
DEPTOR DEP domain containing MTOR-interacting protein -2.09116
NEK2 NIMA-related kinase 2 -2.09067
KNG1 kininogen 1 -2.08728
TTK TTK protein kinase -2.08129
TMA16 translation machinery associated 16 homolog (S. cerevisiae) -2.07852
ATP5PO ATP synthase peripheral stalk subunit OSCP -2.07671
ZNF253 zinc finger protein 253 -2.07656
ZNF184 zinc finger protein 184 -2.07591
ZBTB32 zinc finger and BTB domain containing 32 -2.07186
CLCNKB chloride channel, voltage-sensitive Kb -2.06618
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1 -2.06553
NINJ2 ninjurin 2 -2.06515
ATL2 atlastin GTPase 2 -2.06465
ELP4 elongator acetyltransferase complex subunit 4 -2.06418
NTAQ1 N-terminal glutamine amidase 1 -2.05755
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 -2.05334
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -2.04777
HSPB1 heat shock 27kDa protein 1 -2.04435
LOC105379278 uncharacterized LOC105379278 -2.04066
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.04013
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -2.03997
SOX30 SRY (sex determining region Y)-box 30 -2.03979
NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) -2.03238
ZMYM3 zinc finger, MYM-type 3 -2.02851
ORC3 origin recognition complex, subunit 3 -2.02539
CASKIN2 CASK interacting protein 2 -2.02172
RFX2 regulatory factor X, 2 (influences HLA class II expression) -2.01939
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 -2.01746
MCRS1 microspherule protein 1 -2.01507
VAV3 vav 3 guanine nucleotide exchange factor -2.01405
NR3C2 nuclear receptor subfamily 3, group C, member 2 -2.01278
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -2.00886
CHRM3 cholinergic receptor, muscarinic 3 -2.00852
COQ8A coenzyme Q8A -2.00761
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -2.00749
FIG4 FIG4 phosphoinositide 5-phosphatase -2.0044