CRCGN015_MCF10A.WT.HP_24H:A13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole 96.45 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

56 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:A13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAMLD1 mastermind-like domain containing 1 6.92367
COMP cartilage oligomeric matrix protein 6.1313
HMOX1 heme oxygenase 1 5.03899
TXNRD1 thioredoxin reductase 1 4.93978
E2F2 E2F transcription factor 2 4.01155
CDPF1 cysteine-rich, DPF motif domain containing 1 3.51192
KLHL21 kelch-like family member 21 3.5098
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.38236
ADRB2 adrenoceptor beta 2, surface 3.32963
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 3.32639
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.06288
SPAG4 sperm associated antigen 4 2.90844
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.89868
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 2.8401
COL11A1 collagen, type XI, alpha 1 2.80613
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.78711
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 2.5976
RBBP5 retinoblastoma binding protein 5 2.54807
SKIC2 SKI2 subunit of superkiller complex 2.48808
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa 2.44541
DACT1 dishevelled-binding antagonist of beta-catenin 1 2.41986
CREB1 cAMP responsive element binding protein 1 2.35121
MOK MOK protein kinase 2.34996
VPREB3 pre-B lymphocyte 3 2.29248
DGKI diacylglycerol kinase, iota 2.2842
KEAP1 kelch-like ECH-associated protein 1 2.27729
EVL Enah/Vasp-like 2.25028
HIGD1B HIG1 hypoxia inducible domain family, member 1B 2.23698
WRAP73 WD repeat containing, antisense to TP73 2.21351
SPTA1 spectrin, alpha, erythrocytic 1 2.12663
SQSTM1 sequestosome 1 2.12446
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae) 2.10436
IL6 interleukin 6 2.09726
RECQL4 RecQ protein-like 4 2.08428
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.08015
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative) 2.06934
GPR31 G protein-coupled receptor 31 2.06039
MTM1 myotubularin 1 2.0541
SEC14L4 SEC14-like 4 (S. cerevisiae) 2.05386
ACAA1 acetyl-CoA acyltransferase 1 2.05251
PRR7 proline rich 7 (synaptic) 2.04473
DCAF4 DDB1 and CUL4 associated factor 4 2.04273
EOLA1 endothelium and lymphocyte associated ASCH domain 1 2.0358

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -3.59845
COG2 component of oligomeric golgi complex 2 -3.4743
ALDOC aldolase C, fructose-bisphosphate -3.128
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.80669
HOXA5 homeobox A5 -2.63541
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.53926
NT5DC2 5'-nucleotidase domain containing 2 -2.34397
NDFIP1 Nedd4 family interacting protein 1 -2.17818
SCYL2 SCY1-like 2 (S. cerevisiae) -2.14972
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -2.14214
EFCAB14 EF-hand calcium binding domain 14 -2.12824
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) -2.12768
ATP9A ATPase, class II, type 9A -2.09219