CRCGN015_MCF10A.WT.HP_24H:A14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole 32.15 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

41 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:A14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 5.06251
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.89484
HMOX1 heme oxygenase 1 4.26775
CXCR4 chemokine (C-X-C motif) receptor 4 4.0708
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 3.88148
AGR2 anterior gradient 2 3.74645
GATA2 GATA binding protein 2 3.08913
CDPF1 cysteine-rich, DPF motif domain containing 1 2.91107
FGFR4 fibroblast growth factor receptor 4 2.8692
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.79368
FOS FBJ murine osteosarcoma viral oncogene homolog 2.77813
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.75788
LSR lipolysis stimulated lipoprotein receptor 2.38259
PDLIM1 PDZ and LIM domain 1 2.36699
KEAP1 kelch-like ECH-associated protein 1 2.2614
CIAO2B cytosolic iron-sulfur assembly component 2B 2.24524
SKIC2 SKI2 subunit of superkiller complex 2.11903
SQSTM1 sequestosome 1 2.10574
HOXA10 homeobox A10 2.02768
STK10 serine/threonine kinase 10 2.00973

decreased expression

Symbol Name Standardized Value
LYPLA1 lysophospholipase I -4.00533
VAT1 vesicle amine transport 1 -3.90773
PUF60 poly-U binding splicing factor 60KDa -3.67133
TUBB6 tubulin, beta 6 class V -3.60585
LAP3 leucine aminopeptidase 3 -3.48798
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.45123
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.43311
TNIP1 TNFAIP3 interacting protein 1 -3.06302
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.97902
BASP1 brain abundant, membrane attached signal protein 1 -2.88433
PPIC peptidylprolyl isomerase C (cyclophilin C) -2.60972
MRPL15 mitochondrial ribosomal protein L15 -2.48612
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.41205
SCRIB scribbled planar cell polarity protein -2.33829
ALDOC aldolase C, fructose-bisphosphate -2.23694
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.12179
MCM3 minichromosome maintenance complex component 3 -2.1068
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 -2.09191
LMO2 LIM domain only 2 (rhombotin-like 1) -2.08981
ORAI3 ORAI calcium release-activated calcium modulator 3 -2.08031
LYPLA1-TCEA1 LYPLA1-TCEA1 readthrough -2.0082