CRCGN015_MCF10A.WT.HP_24H:A16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description shahrm perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

107 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:A16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.54305
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.50155
EGR1 early growth response 1 3.286
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 3.25747
SNAP25 synaptosomal-associated protein, 25kDa 2.95303
USP6NL USP6 N-terminal like 2.85071
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.80646
PNKP polynucleotide kinase 3'-phosphatase 2.75339
IGHMBP2 immunoglobulin mu binding protein 2 2.64993
ITFG1 integrin alpha FG-GAP repeat containing 1 2.56475
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.50387
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 2.46466
NLRP4 NLR family, pyrin domain containing 4 2.46265
KLHL21 kelch-like family member 21 2.41666
ZMIZ1 zinc finger, MIZ-type containing 1 2.34769
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.31318
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.28505
SQOR sulfide quinone oxidoreductase 2.2356
CAPRIN2 caprin family member 2 2.22912
MARK3 MAP/microtubule affinity-regulating kinase 3 2.19385
MMP1 matrix metallopeptidase 1 2.19182
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative) 2.17785
TMEM50A transmembrane protein 50A 2.16987
CARS1 cysteinyl-tRNA synthetase 1 2.1677
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.11814
ITGB5 integrin, beta 5 2.09661
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 2.08851
PDIA5 protein disulfide isomerase family A, member 5 2.07051
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.05716
AARS1 alanyl-tRNA synthetase 1 2.05662
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis) 2.05531
INPP1 inositol polyphosphate-1-phosphatase 2.05461
DUSP6 dual specificity phosphatase 6 2.04348
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) 2.03841
HMGA2 high mobility group AT-hook 2 2.03546
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.02836
GLRX glutaredoxin (thioltransferase) 2.01797
PSAT1 phosphoserine aminotransferase 1 2.01656
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.01497
PYCR1 pyrroline-5-carboxylate reductase 1 2.01311
LARP6 La ribonucleoprotein domain family, member 6 2.00847

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -6.01294
ALDOC aldolase C, fructose-bisphosphate -4.69784
ADRB2 adrenoceptor beta 2, surface -4.24768
YME1L1 YME1-like 1 ATPase -4.22889
MTERF3 mitochondrial transcription termination factor 3 -3.54266
ATF5 activating transcription factor 5 -3.2953
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -3.18473
S100A8 S100 calcium binding protein A8 -3.00061
SH3D19 SH3 domain containing 19 -2.96395
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.91534
PRR15L proline rich 15-like -2.89838
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.87517
HEATR1 HEAT repeat containing 1 -2.75768
TXNDC9 thioredoxin domain containing 9 -2.69646
CD81 CD81 molecule -2.67948
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.65201
ABI1 abl-interactor 1 -2.62853
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.6281
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.58148
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.56793
SCARB1 scavenger receptor class B, member 1 -2.55768
SOAT2 sterol O-acyltransferase 2 -2.4872
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.44005
ORC4 origin recognition complex, subunit 4 -2.39076
CBR1 carbonyl reductase 1 -2.38805
TMEM14A transmembrane protein 14A -2.38428
HEMK2 HemK methyltransferase 2, ETF1 glutamine and histone H4 lysine -2.37003
PRPF18 pre-mRNA processing factor 18 -2.36917
COPS4 COP9 signalosome subunit 4 -2.36096
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -2.358
BPIFA1 BPI fold containing family A, member 1 -2.33739
CIAO2B cytosolic iron-sulfur assembly component 2B -2.31246
HSPA14 heat shock 70kDa protein 14 -2.30882
SC5D sterol-C5-desaturase -2.3077
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.2987
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.28583
ZNF669 zinc finger protein 669 -2.25876
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -2.24788
SCGB1D1 secretoglobin, family 1D, member 1 -2.23693
C3AR1 complement component 3a receptor 1 -2.22814
NLRP2B NLR family pyrin domain containing 2B -2.22458
LMBR1 limb development membrane protein 1 -2.19983
UBL5 ubiquitin-like 5 -2.19769
BPHL biphenyl hydrolase-like (serine hydrolase) -2.19071
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) -2.17217
EAPP E2F-associated phosphoprotein -2.14685
TRAPPC2L trafficking protein particle complex 2-like -2.12239
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A -2.10841
STAC SH3 and cysteine rich domain -2.10023
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A -2.08677
MRPL49 mitochondrial ribosomal protein L49 -2.07933
SNX6 sorting nexin 6 -2.07718
GTF2A2 general transcription factor IIA, 2, 12kDa -2.07573
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial -2.07432
GADD45B growth arrest and DNA-damage-inducible, beta -2.07143
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.0698
PNPO pyridoxamine 5'-phosphate oxidase -2.04257
JPT2 Jupiter microtubule associated homolog 2 -2.02468
MTPAP mitochondrial poly(A) polymerase -2.02321
RNASE7 ribonuclease, RNase A family, 7 -2.01988
KITLG KIT ligand -2.01323
KRT34 keratin 34, type I -2.00847
TREM1 triggering receptor expressed on myeloid cells 1 -2.0065
C1QA complement component 1, q subcomponent, A chain -2.00582
VAMP8 vesicle-associated membrane protein 8 -2.00529
MARCO macrophage receptor with collagenous structure -2.00391