CRCGN015_MCF10A.WT.HP_24H:A17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description shahrm perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

29 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:A17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 4.22042
CCL2 chemokine (C-C motif) ligand 2 3.72903
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 3.31777
ADAM10 ADAM metallopeptidase domain 10 3.18837
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 3.03997
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.73545
HBA1 hemoglobin, alpha 1 2.51528
MAP2K5 mitogen-activated protein kinase kinase 5 2.49795
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.47126
SSBP2 single-stranded DNA binding protein 2 2.13777
ZNF652 zinc finger protein 652 2.03491

decreased expression

Symbol Name Standardized Value
PCCB propionyl CoA carboxylase, beta polypeptide -4.37822
ALDOC aldolase C, fructose-bisphosphate -4.3493
CHMP4B charged multivesicular body protein 4B -4.19159
LAP3 leucine aminopeptidase 3 -3.61182
KIF20A kinesin family member 20A -3.42216
KIF14 kinesin family member 14 -2.94906
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.94254
KDM3A lysine (K)-specific demethylase 3A -2.59002
CYCS cytochrome c, somatic -2.55433
ECH1 enoyl CoA hydratase 1, peroxisomal -2.46211
MSMO1 methylsterol monooxygenase 1 -2.32223
MVP major vault protein -2.26816
TXNRD1 thioredoxin reductase 1 -2.15206
DUSP14 dual specificity phosphatase 14 -2.08654
MTFR1 mitochondrial fission regulator 1 -2.05226
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.0495
GMPR2 guanosine monophosphate reductase 2 -2.03482
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -2.00025