CRCGN015_MCF10A.WT.HP_24H:A19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-[4-(5-nitro-2-furyl)-2-thiazo?lyl]formamide 98.33 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

82 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:A19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
EML3 echinoderm microtubule associated protein like 3 4.76189
PROS1 protein S (alpha) 4.35416
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.33082
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 3.89307
CDPF1 cysteine-rich, DPF motif domain containing 1 3.37084
UBE2W ubiquitin-conjugating enzyme E2W (putative) 3.12548
RECK reversion-inducing-cysteine-rich protein with kazal motifs 3.11954
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.8133
RGS2 regulator of G-protein signaling 2 2.63198
CENPT centromere protein T 2.58881
SMNDC1 survival motor neuron domain containing 1 2.52014
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 2.51629
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.4626
CCL14 chemokine (C-C motif) ligand 14 2.42824
LDB2 LIM domain binding 2 2.33091
SQOR sulfide quinone oxidoreductase 2.31659
ZNF544 zinc finger protein 544 2.304
ARL2BP ADP-ribosylation factor-like 2 binding protein 2.27904
GOLT1B golgi transport 1B 2.27223
MYL9 myosin, light chain 9, regulatory 2.26507
TAOK1 TAO kinase 1 2.21073
ADM2 adrenomedullin 2 2.19032
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 2.18785
CYCS cytochrome c, somatic 2.1867
ZNF586 zinc finger protein 586 2.18557
LMF2 lipase maturation factor 2 2.15653
SKIC8 SKI8 subunit of superkiller complex 2.1387
H1-3 H1.3 linker histone, cluster member 2.13722
SKI SKI proto-oncogene 2.13196
ATMIN ATM interactor 2.12836
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.12163
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 2.11535
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2 2.10779
GNG11 guanine nucleotide binding protein (G protein), gamma 11 2.10564
CHP2 calcineurin-like EF-hand protein 2 2.10239
WASHC5 WASH complex subunit 5 2.10085
MRPL11 mitochondrial ribosomal protein L11 2.09038
TOE1 target of EGR1, member 1 (nuclear) 2.0862
XAF1 XIAP associated factor 1 2.0823
COMP cartilage oligomeric matrix protein 2.08164
KDM8 lysine (K)-specific demethylase 8 2.04388
ISYNA1 inositol-3-phosphate synthase 1 2.03859
PRKACB protein kinase, cAMP-dependent, catalytic, beta 2.03475
PLIN1 perilipin 1 2.03445
ZNF268 zinc finger protein 268 2.03179
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.02244
MACO1 macoilin 1 2.00989
TXNL4B thioredoxin-like 4B 2.00871

decreased expression

Symbol Name Standardized Value
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -5.37971
TNIP1 TNFAIP3 interacting protein 1 -4.99965
ENOPH1 enolase-phosphatase 1 -4.8048
CD58 CD58 molecule -4.25516
ANXA2 annexin A2 -3.91023
CLTC clathrin, heavy chain (Hc) -3.84804
CAB39 calcium binding protein 39 -3.48226
CREG1 cellular repressor of E1A-stimulated genes 1 -3.25782
CRTAP cartilage associated protein -3.17952
CASC3 cancer susceptibility candidate 3 -2.92404
KIF20A kinesin family member 20A -2.87542
TM9SF2 transmembrane 9 superfamily member 2 -2.81394
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.66333
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa -2.63098
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.62004
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -2.55582
ALDOC aldolase C, fructose-bisphosphate -2.43421
FBXO7 F-box protein 7 -2.41997
SCAND1 SCAN domain containing 1 -2.38805
CD81 CD81 molecule -2.297
OXA1L oxidase (cytochrome c) assembly 1-like -2.28735
COPZ1 coatomer protein complex, subunit zeta 1 -2.26861
ARFIP2 ADP-ribosylation factor interacting protein 2 -2.26402
BAG3 BCL2-associated athanogene 3 -2.18759
UBE2C ubiquitin-conjugating enzyme E2C -2.14236
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 -2.11129
STX10 syntaxin 10 -2.10659
CMTM6 CKLF-like MARVEL transmembrane domain containing 6 -2.10475
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.0893
TSPAN3 tetraspanin 3 -2.07871
GLB1 galactosidase, beta 1 -2.03836
CCDC170 coiled-coil domain containing 170 -2.03163
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -2.02696
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -2.01846