CRCGN015_MCF10A.WT.HP_24H:A21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-[4-(5-nitro-2-furyl)-2-thiazo?lyl]formamide 10.93 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

38 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:A21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 5.36921
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 5.22979
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.77355
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 4.23126
KLHL21 kelch-like family member 21 4.05499
AGR2 anterior gradient 2 3.88717
MICALL1 MICAL-like 1 3.16609
KIF5C kinesin family member 5C 2.99685
BZW2 basic leucine zipper and W2 domains 2 2.77051
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.5665
KDM5D lysine (K)-specific demethylase 5D 2.46935
PDLIM1 PDZ and LIM domain 1 2.45178
CRYAB crystallin, alpha B 2.33531
CNPY3 canopy FGF signaling regulator 3 2.30809
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.27571
PACS2 phosphofurin acidic cluster sorting protein 2 2.20789
KANK1 KN motif and ankyrin repeat domains 1 2.19634
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.16795
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase 2.15842
AMOTL2 angiomotin like 2 2.09182
NOTCH1 notch 1 2.04519
PICK1 protein interacting with PRKCA 1 2.0026

decreased expression

Symbol Name Standardized Value
KIF14 kinesin family member 14 -4.82675
CD81 CD81 molecule -4.1831
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.93286
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.9164
DSG2 desmoglein 2 -2.79869
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.70067
ARID4B AT rich interactive domain 4B (RBP1-like) -2.65987
CDC20 cell division cycle 20 -2.44488
KDM3A lysine (K)-specific demethylase 3A -2.43512
UBA1 ubiquitin-like modifier activating enzyme 1 -2.37168
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -2.14479
SMC1A structural maintenance of chromosomes 1A -2.12039
DCBLD2 discoidin, CUB and LCCL domain containing 2 -2.11329
RLF rearranged L-myc fusion -2.09256
RPGR retinitis pigmentosa GTPase regulator -2.01651
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.00107