CRCGN015_MCF10A.WT.HP_24H:A23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (4-chloro-2-methylphenoxy)acetic acid 35.53 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

50 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:A23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CNPY3 canopy FGF signaling regulator 3 4.26041
PRR7 proline rich 7 (synaptic) 4.00766
NOSIP nitric oxide synthase interacting protein 3.64842
GHR growth hormone receptor 3.17961
VAV3 vav 3 guanine nucleotide exchange factor 2.99594
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.95561
LOXL1 lysyl oxidase-like 1 2.95314
MRPL11 mitochondrial ribosomal protein L11 2.71304
KDM5D lysine (K)-specific demethylase 5D 2.65036
CCNF cyclin F 2.63515
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.51717
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 2.41407
SLCO4C1 solute carrier organic anion transporter family, member 4C1 2.35177
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase 2.29842
GTPBP8 GTP-binding protein 8 (putative) 2.29736
H2AZ2 H2A.Z variant histone 2 2.24671
USP9Y ubiquitin specific peptidase 9, Y-linked 2.21577
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae) 2.20388
TUBA3C tubulin, alpha 3c 2.19505
CAPN1 calpain 1, (mu/I) large subunit 2.18798
PCBP4 poly(rC) binding protein 4 2.18711
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2.1538
ANKRD36C ankyrin repeat domain 36C 2.12176
TNRC6B trinucleotide repeat containing 6B 2.11959
GOLT1B golgi transport 1B 2.11386
UBTF upstream binding transcription factor, RNA polymerase I 2.11049
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2.10304
PTK2B protein tyrosine kinase 2 beta 2.09204
MRPL37 mitochondrial ribosomal protein L37 2.06663
ZNF205 zinc finger protein 205 2.03409
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.0316
FSD1 fibronectin type III and SPRY domain containing 1 2.01708
TFEB transcription factor EB 2.01352
UBXN6 UBX domain protein 6 2.0025
LSR lipolysis stimulated lipoprotein receptor 2.00114

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -4.87106
MSN moesin -4.83973
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.4584
VDAC1 voltage-dependent anion channel 1 -3.12925
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.80038
RBM28 RNA binding motif protein 28 -2.71889
SCYL3 SCY1-like 3 (S. cerevisiae) -2.59621
RHOA ras homolog family member A -2.31447
PUS7 pseudouridylate synthase 7 (putative) -2.18234
OXA1L oxidase (cytochrome c) assembly 1-like -2.15289
NUP205 nucleoporin 205kDa -2.12061
KDM3A lysine (K)-specific demethylase 3A -2.11521
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 -2.05202
CBR3 carbonyl reductase 3 -2.04566
ZNF7 zinc finger protein 7 -2.03645