CRCGN015_MCF10A.WT.HP_24H:B04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

134 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:B04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TBX2 T-box 2 3.92081
CIAO3 cytosolic iron-sulfur assembly component 3 3.72541
E2F2 E2F transcription factor 2 3.68222
CHMP6 charged multivesicular body protein 6 3.49437
SYNE2 spectrin repeat containing, nuclear envelope 2 3.41318
LAGE3 L antigen family, member 3 3.32114
MAMLD1 mastermind-like domain containing 1 3.08731
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.05015
FGFR4 fibroblast growth factor receptor 4 3.02783
CCDC92 coiled-coil domain containing 92 2.64503
ZNF589 zinc finger protein 589 2.51636
GRIK3 glutamate receptor, ionotropic, kainate 3 2.47646
RORB RAR-related orphan receptor B 2.45969
LUC7L LUC7-like (S. cerevisiae) 2.44467
OCM2 oncomodulin 2 2.34642
FGF16 fibroblast growth factor 16 2.33668
GRAPL GRB2-related adaptor protein-like 2.32867
EXTL1 exostosin-like glycosyltransferase 1 2.31478
CRISP1 cysteine-rich secretory protein 1 2.28172
EPHA5 EPH receptor A5 2.26571
SMYD5 SMYD family member 5 2.26563
TAS2R13 taste receptor, type 2, member 13 2.23304
COL11A1 collagen, type XI, alpha 1 2.22756
IFNA7 interferon, alpha 7 2.2261
FSHR follicle stimulating hormone receptor 2.22318
DEFB126 defensin, beta 126 2.21779
TAS2R3 taste receptor, type 2, member 3 2.21706
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 2.21582
ADAM7 ADAM metallopeptidase domain 7 2.21059
SPINT4 serine peptidase inhibitor, Kunitz type 4 2.20599
USP27X ubiquitin specific peptidase 27, X-linked 2.20178
CBX2 chromobox homolog 2 2.19596
BMP3 bone morphogenetic protein 3 2.19416
MYH13 myosin, heavy chain 13, skeletal muscle 2.18946
CNMD chondromodulin 2.18557
OR1D4 olfactory receptor, family 1, subfamily D, member 4 (gene/pseudogene) 2.18136
CAMK4 calcium/calmodulin-dependent protein kinase IV 2.17388
EDDM3B epididymal protein 3B 2.16204
SLC66A2 solute carrier family 66 member 2 2.15448
RRH retinal pigment epithelium-derived rhodopsin homolog 2.14701
PGAP6 post-GPI attachment to proteins 6 2.13989
DUSP21 dual specificity phosphatase 21 2.13761
BTNL2 butyrophilin-like 2 2.1244
ZBED1 zinc finger, BED-type containing 1 2.12253
KRT36 keratin 36, type I 2.11913
TIAM1 T-cell lymphoma invasion and metastasis 1 2.11686
IFNA21 interferon, alpha 21 2.11641
PRDM5 PR domain containing 5 2.11571
ELSPBP1 epididymal sperm binding protein 1 2.115
DLX6 distal-less homeobox 6 2.11493
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.11442
WDR4 WD repeat domain 4 2.11376
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.11369
CCDC177 coiled-coil domain containing 177 2.11209
NKX6-1 NK6 homeobox 1 2.11033
MED22 mediator complex subunit 22 2.10418
AGTR2 angiotensin II receptor, type 2 2.10152
H1-1 H1.1 linker histone, cluster member 2.10038
SPRYD7 SPRY domain containing 7 2.09256
RFX4 regulatory factor X, 4 (influences HLA class II expression) 2.0916
CRHR2 corticotropin releasing hormone receptor 2 2.09135
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13 2.08934
PLA2G2F phospholipase A2, group IIF 2.08915
MMP26 matrix metallopeptidase 26 2.08127
PCDHGA1 protocadherin gamma subfamily A, 1 2.07345
SPATA31A3 SPATA31 subfamily A, member 3 2.07233
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 2.07028
RUFY1 RUN and FYVE domain containing 1 2.06983
FAAP24 FA core complex associated protein 24 2.06918
OR5I1 olfactory receptor, family 5, subfamily I, member 1 2.06829
CDON cell adhesion associated, oncogene regulated 2.06746
KIF26B kinesin family member 26B 2.06603
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa 2.06583
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa 2.06569
AFF2 AF4/FMR2 family, member 2 2.05922
TBCEL tubulin folding cofactor E-like 2.05915
NRBP1 nuclear receptor binding protein 1 2.05824
ZNF507 zinc finger protein 507 2.05717
HROB homologous recombination factor with OB-fold 2.05451
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 2.05355
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 2.04909
POU6F2 POU class 6 homeobox 2 2.04859
EDDM3A epididymal protein 3A 2.04835
GPR3 G protein-coupled receptor 3 2.04823
IFNW1 interferon, omega 1 2.04118
ZNF37A zinc finger protein 37A 2.04049
EHMT1 euchromatic histone-lysine N-methyltransferase 1 2.04043
MEP1A meprin A, alpha (PABA peptide hydrolase) 2.03929
PHF13 PHD finger protein 13 2.03475
OR1A1 olfactory receptor, family 1, subfamily A, member 1 2.03221
HNF4G hepatocyte nuclear factor 4, gamma 2.02398
BMP15 bone morphogenetic protein 15 2.02082
LSAMP limbic system-associated membrane protein 2.01959
RCVRN recoverin 2.01752
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 2.01662
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 2.0162
RAPSN receptor-associated protein of the synapse 2.01587
LIPC lipase, hepatic 2.01559
UGDH UDP-glucose 6-dehydrogenase 2.01426
PRKG1 protein kinase, cGMP-dependent, type I 2.01348
CCL16 chemokine (C-C motif) ligand 16 2.01322
CCDC33 coiled-coil domain containing 33 2.01265
RAB40C RAB40C, member RAS oncogene family 2.0119
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 2.01061
RASL10A RAS-like, family 10, member A 2.00987
KRTAP2-3 keratin associated protein 2-3 2.00839
TREML2 triggering receptor expressed on myeloid cells-like 2 2.0072
SATB1 SATB homeobox 1 2.0067
ANP32D acidic (leucine-rich) nuclear phosphoprotein 32 family, member D 2.00662
KMT2D lysine (K)-specific methyltransferase 2D 2.00598
OR11A1 olfactory receptor, family 11, subfamily A, member 1 2.00584
EPB41L5 erythrocyte membrane protein band 4.1 like 5 2.001

decreased expression

Symbol Name Standardized Value
MSN moesin -4.29385
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.95186
PCCB propionyl CoA carboxylase, beta polypeptide -3.52138
FABP5 fatty acid binding protein 5 (psoriasis-associated) -3.48331
CD81 CD81 molecule -3.47228
TNIP1 TNFAIP3 interacting protein 1 -3.35427
CD44 CD44 molecule (Indian blood group) -3.29885
BAG3 BCL2-associated athanogene 3 -3.29167
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.95765
LYPLA1 lysophospholipase I -2.75739
CYCS cytochrome c, somatic -2.72586
TUBA4A tubulin, alpha 4a -2.69835
C2CD5 C2 calcium-dependent domain containing 5 -2.64245
GOLT1B golgi transport 1B -2.37846
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) -2.17998
CAB39 calcium binding protein 39 -2.11389
INTS13 integrator complex subunit 13 -2.09804
EIF5 eukaryotic translation initiation factor 5 -2.05274
TIMP1 TIMP metallopeptidase inhibitor 1 -2.03745
SDCBP syndecan binding protein (syntenin) -2.03714
SCYL3 SCY1-like 3 (S. cerevisiae) -2.03442
ARF4 ADP-ribosylation factor 4 -2.01135