CRCGN015_MCF10A.WT.HP_24H:B08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (2s)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid 32.3 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

23 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:B08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADO 2-aminoethanethiol (cysteamine) dioxygenase 4.56124
IGHMBP2 immunoglobulin mu binding protein 2 3.81044
SSBP2 single-stranded DNA binding protein 2 3.67456
DENND2D DENN/MADD domain containing 2D 3.59847
KIF5C kinesin family member 5C 3.20435
PPARG peroxisome proliferator-activated receptor gamma 2.99089
FKBP14 FK506 binding protein 14, 22 kDa 2.72833
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.61518
MELK maternal embryonic leucine zipper kinase 2.27146
HBA1 hemoglobin, alpha 1 2.27132
SCG5 secretogranin V 2.15808
TBPL1 TBP-like 1 2.10191

decreased expression

Symbol Name Standardized Value
PRPF4 pre-mRNA processing factor 4 -3.38026
PRCP prolylcarboxypeptidase (angiotensinase C) -3.34824
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.16967
REEP5 receptor accessory protein 5 -3.03004
COG7 component of oligomeric golgi complex 7 -2.96124
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.81208
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.63171
CDK4 cyclin-dependent kinase 4 -2.46573
BSPRY B-box and SPRY domain containing -2.37012
ANXA2 annexin A2 -2.21665
CDC45 cell division cycle 45 -2.04737